# Profoundd archive — Epstein Files
# Bates number: EFTA01966177
# Title:        To: Jeffrey Epsteinfleevacation©gmail.comj
# Dataset:      10
# Pages:        2
# Tags:         epstein, doj, dataset-10
# Source PDF:   https://profoundd.com/epstein-docs/EFTA01966177/download
# Doc viewer:   https://profoundd.com/epstein-docs/EFTA01966177
#
# Text below is what Profoundd has extracted from the source PDF.
# 'ocr-enriched' tag means OCR was applied to scan-only pages.
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#----------------------------------------------------------------------

=== SUMMARY ===
To: Jeffrey Epsteinfleevacation©gmail.comj From: jeffreyepsteinorg©gmail.com on behalf of Sent Wed 7/17/2013 3:51:36 AM Subject: Fwd: amyloid increases homocysteic acid toxicity Forwarded message From: Tohru Date: The, Jul 16, 2013 at 7:00 PM Suliect: am loid increases homoc stele acid toxici To Dear Christina; I am afraid Jeffrey has a question about the relationship between amyloid beta and homocysteic acid in blood for Alzheimer's disease process. Amyloid hypothesis is still valid for prevent


=== EXTRACTED TEXT ===
To: Jeffrey Epsteinfleevacation©gmail.comj 
From: jeffreyepsteinorg©gmail.com on behalf of 
Sent Wed 7/17/2013 3:51:36 AM 
Subject: Fwd: amyloid increases homocysteic acid toxicity 
 Forwarded message 
From: Tohru 
Date: The, Jul 16, 2013 at 7:00 PM 
Suliect: am loid increases homoc stele acid toxici 
To 
Dear Christina; 
I am afraid Jeffrey has a question about the relationship between amyloid beta and 
homocysteic acid in blood for Alzheimer's disease process. 
Amyloid hypothesis is still valid for preventing AD. We already observed that homocysteic 
acid toxicity, especially, neurodegenerative toxicity, will increase in the presence of 
amyloid. 
However it has been observed that amyloid protein is present in normal brain, which 
shows that amyloid itself has no toxicity for brain work. 
Homocysteic acid has the original pathogen for AD process. Early onset of AD, familial AD, 
has higher production of amyloid, which increases the homocysteic acid toxicity, then very 
lower level of homocysteic acid can start the disease process. Recent reports indicate that 
ApoE4 increases the permeability of blood brain barrier, which allows the invasion of 
lower level of homocysteic acid in blood into brain. 
This my hypothesis is strongly supported by my TSH1 recovery, because TSH1 decreased 
homocysteic acid level in blood and blocked homocysteic acid toxicity in brain. 
Now I am sincerely request your support. 
EFTA_R1_00444219 
EFTA01966177
Sincerely yours 
Tohru 
EFTA R1_00444220 
EFTA01966178