Design clinical trials with women in mind. Educating investigators, developers, clinical trial staff and patients, along with improved clinical trial access, especially for women from underserved populations, is essential for advancing women’s health research. Clinical trials must also be designed to account for sex-based differences in physiological mechanisms and treatment responses. Deepen insights on sex-specific differences. To account for sex differences and ensure transparency about safety and efficacy for all patients, clinical guidelines as well as product package inserts and patient information leaflets need to be updated. Lastly, implementing the SAGER guidelines in scientific journals will improve transparency when reporting sex-specific differences – clearly a quick win.Women have waited long enough to live in better health; the time for change is now. Prioritizing innovation and inclusion can break down the barriers hindering progress in women’s health research while driving global economic growth. Uniting industry leaders, regulators, other experts and patients is a decisive step towards reshaping the landscape of women’s health science and innovation one policy at a time. These policies will drive more robust science that not only improves health outcomes for women but also promises far- reaching economic benefits for all.4 5 Prescription for Change: Policy Recommendations for Women’s Health Research 5

Prescription for Change 2025