–Premenstrual syndrome (PMS) affects 20–40% of women of reproductive age.9 PMS represents potential estimated gains of 2.1 million annual DALYs and $115 billion in annual GDP in the women’s health gap. –Migraine affects approximately 21% of women globally (0.8 billion women).10 Migraine represents potential estimated gains of 2.7 million annual DALYs and $80 billion in annual GDP in the women’s health gap. –Endometriosis is an oestrogen-related condition affecting one in 10 women between the ages of 15 and 45 – at least 190 million women globally.11 Endometriosis represents potential estimated gains of 0.25 million annual DALYs and $12 billion in annual GDP in the women’s health gap. Measuring and tracking progress is an important and meaningful first step in the journey to equitable health and healthcare for women and girls. The Women’s Health Impact Tracking (WHIT) platform was created by the Global Alliance for Women’s Health to address this need. WHIT is designed to measure the impact of health conditions that contribute to the women’s health gap (in terms of disability, mortality and consequent economic effect). It also provides country- level indicators of data availability, treatment effectiveness and quality and appropriateness of care delivery. WHIT was designed by stakeholders, for stakeholders, as a practical and tactical tool to track progress over time and shine a light on opportunities to accelerate the deployment of proven solutions to close the women’s health gap. The imperative and actions stakeholders can take to close the women’s health gap can be explored with the following framework: Women’s health data is often not collected, not published in the public domain, or incomplete. Improving the accuracy of data collection and setting standards for sex- and gender-based data collection could help to clarify the true burden of disease, particularly for women-specific conditions. Research funding for women’s health and the drivers of sex- based differences, particularly for conditions that affect the health span, is not proportional to the burden of disability attributed to these conditions. Sex-disaggregated analysis and basic science research into hormone health and female biology could help reveal how women are affected disproportionately or differently from men by many conditions. Additional research could help the understanding of conditions specific to women and illuminate disparities.Clinical practice guidelines (CPGs) often do not reflect best-practice clinical care for women, including the understanding of sex-based differences in the presentation and treatment of conditions. Delivering sex- and gender-appropriate and evidence-based healthcare, through healthcare delivery systems designed for women and equipped to address health-related social needs (HRSN), could improve health outcomes for women. Mitigating health disparities could have a greater impact on mortality for the selected conditions than any single treatment recently studied in later- stage clinical trials. Health and social systems can consider how to better acknowledge and address differences in health outcomes and promote global health equity. Additional funding in research, clinical education and training, care delivery and the development of innovative interventions is needed to accelerate progress. Each and every stakeholder has a role in advancing the health of women. The impact of these actions can, and will, reach far beyond the lives of individual women. Healthier women are cornerstones of prosperous communities, vibrant workplaces and resilient economies. Better health for women throughout their lives could create at least $1 trillion in annual incremental economic growth by 2040.12 This is distinct from the market for new products and services that can be developed to address the many unmet needs of women today, the size of which may be more than $500 billion for the selected conditions. Investors, researchers, governments, non-profits, providers, life sciences companies and communities may want to reinvigorate their consideration and commitments to women’s health. Empowering every woman and girl around the world with awareness and the information needed to take charge of her health is critical. Misinformation and decreasing awareness of women’s health stalls advancement and can impair women from living healthier and more productive lives. Progress is possible, and closing the women’s health gap is achievable. Now is the time for action that will improve the lives of women and girls around the world and strengthen the global economy.Count women Study womenCare for women Include all women Invest in women Blueprint to Close the Women’s Health Gap: How to Improve Lives and Economies for All 5

Blueprint to Close the Women%E2%80%99s Health Gap 2025