Step-wise approach to assess the burden of climate-related diseases, analyse unmet needs and prioritize investments to mitigate health impactsFIGURE A1 Prioritization of unmet needs Assessment of the bur den of disease Development of climate and health investment case Leverage health outcomes model fr om the 2024 r eport1 to identify highest climate impacts on health acr oss geographies Engage experts to highlight priority diseases not cover ed in the 2024 r eport1 10-15 health outcomes with highest burden acr oss geographiesIdentify medical interventions and unmet medical needs for the selected health outcomes, by r egion Prioritize unmet needs based on existing and pipeline solutions, associated size of health outcomes and commer cial potentialAssess life sciences sector potential to addr ess unmet needs Develop a high-level investment case to assess commer cial viability and health impr ovement potential Prioritized list of high impact unmet needs by disease and r egionCommer cial and ethical ROI assessment for prioritized unmet needs1 2 3 1. World Economic Forum and Oliver Wyman, Quantifying the Impact of Climate Change on Human Health, 2024. Source: World Economic Forum and Oliver Wyman analysis. The first step used the Forum’s climate-related health impact matrix to identify the diseases, regions and populations most affected by rising temperatures and climate change. This focused on the impact of six major climate events that increase in severity and frequency because of global warming – flooding, droughts, heatwaves, tropical storms, wildfires and rising sea levels. These events also cause significant environmental and economic damage, including destruction of agriculture, deforestation, desertification, coastal erosion, water scarcity and soil degradation.Data linking the effects of these weather events on health outcomes and determinants was gathered from various sources, including WHO’s climate change framework, the UN’s Intergovernmental Panel on Climate Change (IPCC), the World Meteorological Organization (WMO) and over 50 medical and scientific research publications. The final list consisted of eight priority diseases: vector-borne diseases (malaria and dengue), mental health disorders (GAD, PTSD), stunting, heat- related illnesses, hypertension and asthma. Starting point: highest burden climate-induced diseases1 Healthcare in a Changing Climate: Investing in Resilient Solutions 33

Healthcare in a Changing Climate 2025