Healthcare in a Changing Climate 2025

The second step involved identifying current therapies and unmet medical needs for the priority diseases across geographies (see Figure A2). These were based on the availability of existing and pipeline solutions, the scale of the health impact and their commercial potential. The approach began with a thorough analysis of each priority disease, detailing its etiology and pathophysiology. This included explanations of the underlying causes, biological mechanisms, symptoms and diagnostic processes. The progression and prognosis of each disease were outlined, alongside preventive measures and risk factors. Regional variations in disease manifestation were also examined to ensure a comprehensive understanding of the health outcomes in different geographies. Prioritization of unmet medical needs by disease2 Phased approach to describe the disease, assess treatments and prioritize unmet needs with the largest impact potentialFIGURE A2 Prioritization of unmet needs2 Detail tr eatments and identify unmet needsDescribe etiology and pathophysiology Assess and prioritize unmet needs Provide disease overview , explaining causes, biological mechanisms, symptoms and diagnostics Detail pr ognosis and evolution of the disease, pr eventive measur es and risk factors, dif ferences acr oss geographies Disease overview , etiology and pathophysiologyReview existing clinical guidelines and R&D pipeline covering medications, medical devices and digital solutions Identify unmet needs for high bur den disease along pr evention, diagnostics and tr eatmentPrioritize high impact unmet needs based on their potential to r educe the bur den of disease and impr ove quality of life Leverage scientific literatur e and pr ess releases and validate with scientific and medical experts Overview of existing and emerging medical interventions and corr esponding unmet needsPrioritized list of unmet needs with highest impact potentialA B C Source: World Economic Forum and Oliver Wyman analysis. Healthcare in a Changing Climate: Investing in Resilient Solutions 34