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Principal Investigator: Lucie Kalousova
Organization: VANDERBILT UNIVERSITY
Fiscal Year: 2024
Award: $122,850
Funding agency: National Institute on Aging
Project Summary
Women are more likely to develop Alzheimer's disease and related dementias (ADRD) later in life. The gender
disparity can be partially explained by sex-related biological differences and women's longer life expectancy.
The remaining portion is ascribed to structural inequalities. Building on prior research, I hypothesize that
women's unequal access to employment has contributed to their cognitive disadvantage by restricting their
ability to cognitive enrichment through the life course and other valuable employment-related resources. The
proposed Mentored Research Scientist Development Award (K01) will give me protected time and resources to
undertake additional training in social determinants of ADRD, implementing quasi-experimental analytic
methods using life course data, and survey cognitive health assessment. I will also bolster my understanding of
the physiological underpinnings of ADRD to be able to pursue an interdisciplinary research agenda. Supported
by a team of highly accomplished mentors in neuroscience, psychology, gerontology, epidemiology, and
population health, I will carry out innovative and rigorous quasi-experimental studies that approach the
question of women's labor force disadvantage implications for cognitive disparities from a life course
perspective. First, I will use the Irish TILDA cohort to examine the effects of married women's labor force
exclusion on their cognitive outcomes later in life. Second, I will use UK's ELSA data to study the effects of the
introduction of paid and protected maternity leave on British women's cognitive outcomes later in life. Finally, I
will use American HRS data to evaluate the impact of women's earlier retirement on their cognitive outcomes
later in life. The datasets selected combine high-quality social, cognitive, and health data and rich life course
histories. The skills and expertise I will gain will put me in a strong position to make major contributions to our
understanding of structural determinants of disparities in cognitive health, become an independent NIH-funded
researcher, and lay the foundation of my new research program in employment, policy, and cognitive
disparities.
Terms: <0-11 years old><21+ years old><AD dementia><AD related dementia><ADRD><Academic Medical Centers><Address><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><American><Area><Biological><Birth><British><Causality><Child><Child Youth><Childbirth><Children (0-21)><Cognitive><Cognitive Discrimination><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Data Set><Dementia><Disadvantaged><Discrimination><Disparities><Disparity><Disturbance in cognition><Economics><Education><Educational aspects><Eire><Employment><Epidemiology><Etiology><Exclusion><Family Leave><Female Roles><Foundations><Fracture><Funding><Gender><Gerontology><Goals><Health><Health and Retirement Study><History><Home><Impaired cognition><Inequality><Interdisciplinary Research><Interdisciplinary Study><Investigators><Ireland><Irish Free State><K01 Award><K01 Mechanism><K01 Program><Labor Forces><Lead><Left><Life><Life Cycle><Life Cycle Stages><Life Expectancy><Life Style><Lifestyle><Marriage><Maternity leave><Measurement><Measures><Medical><Memory><Mental Health><Mental Hygiene><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Mentorship><Michigan><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Natural experiment><Nerve Degeneration><Neuron Degeneration><Neurosciences><Outcome><Parturition><Pathway interactions><Pb element><Persons><Physiologic><Physiological><Policies><Population><Population Study><Position><Positioning Attribute><Preparation><Primary Senile Degenerative Dementia><Probability><Psychological Health><Psychology><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><Recording of previous events><Research><Research Personnel><Research Resources><Research Scientist Development Award><Researchers><Resources><Retirement><Risk><Role><Science><Shapes><Social Network><Social Sciences><Societal Factors><Survey Instrument><Surveys><Time><Training><United States><United States National Institutes of Health><Universities><University Medical Centers><Woman><Women's Role><Work><adulthood><ages><analytical method><biologic><bone fracture><causation><child birth><cognitive dysfunction><cognitive enhancement><cognitive loss><cohort><disease causation><disparity in health><economic><epidemiologic><epidemiological><gender disparity><gerontologic><health assessment><health data><health disparity><heavy metal Pb><heavy metal lead><histories><homes><innovate><innovation><innovative><kids><labor force participation><late life><life course><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><older adult><older adulthood><pathway><peer><physical conditioning><physical health><population health><population-based study><population-level study><preparations><primary degenerative dementia><programs><retirements><senile dementia of the Alzheimer type><sex><skills><social><social determinants><social norm><social role><sociodeterminant><structural determinants><structural factors><studies of populations><study of the population><tool><youngster>