Vaccines Enabling HIV Prevention Targeting Germinal Center Enhancement with Engineered Slow Release Nanoparticles
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Principal Investigator: SILVIA GRAMA Organization: NANOCOMPOSIX, INC. Fiscal Year: 2020 Award: $300,000 Funding agency: National Institute of Allergy and Infectious Diseases Particle-Based Co-Delivery of HIV Immunogens as Next-Generation HIV Vaccines: A major focus of HIV vaccine research has been the development of immunogens that elicit broadly neutralizing antibody responses targeting the envelope protein (Env). While the field has predominantly focused on immunogen design and soluble antigens, the targeted and controlled delivery of antigens has not received much attention and is a gap in the HIV field that needs to be addressed. Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, selfamplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies. Terms: <AIDS Virus><AIDS prevention><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adjuvant><Affinity><Antibody Response><Antigen Targeting><Antigens><Attention><Chitosan><Confocal Microscopy><Core Particle><Development><Engineering><Envelope Protein><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Germinal Center><HIV><HIV Prevention><HIV envelope protein><HIV vaccine><HIV/AIDS Vaccines><HIV/AIDS prevention><Human Immunodeficiency Viruses><Immune response><Immunological response><LAV-HTLV-III><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphadenopathy-Associated Virus><Lymphatic nodes><Messenger RNA><Non-Polyadenylated RNA><Nucleic Acids><Nucleosome Core><Nucleosome Core Particle><Poliglusam><RNA><RNA Gene Products><Research><Ribonucleic Acid><Structure of germinal center of lymph node><Surface><Vaccine Research><Vaccines><Virus-HIV><base><design><designing><developmental><env Antigens><env Gene Products><env Polyproteins><env Protein><ex vivo imaging><flow cytophotometry><host response><human immunodeficiency virus vaccine><imaging in vivo><immunogen><immunoresponse><in vivo imaging><lymph gland><lymph nodes><lymphnodes><mRNA><monomer><nano particle><nano particle delivery><nano-sized particle><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><neutralizing antibody><next generation><particle><prophylactic><response><trafficking>