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Principal Investigator: Linda G Kahn
Organization: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Fiscal Year: 2024
Award: $248,784
Funding agency: National Institute of Environmental Health Sciences
PROJECT SUMMARY/ABSTRACT
In the United States, increasing numbers of women are experiencing pregnancy complications such as
preeclampsia, eclampsia, and gestational hypertension that can put their own and their children’s immediate
and long-term health at risk. In particular, these hypertensive disorders of pregnancy are associated with
increased incidence of postnatal cardiovascular disease in women. The link appears to be the placenta, an
organ that both regulates nutrient flow to the developing fetus and influences maternal cardiovascular function.
Nonpersistent endocrine disrupting chemicals (EDCs), including bisphenols found in plastics and phthalates
found in personal care products, have been associated with cardiovascular disease and may also be
associated with placental dysfunction. Over the course of my masters, doctoral, and postdoctoral training, I
have begun to develop a portfolio of published research in both environmental and reproductive epidemiology,
with a particular emphasis on identifying underlying biological mechanisms. My prior education and experience
positions me well to undertake my proposed K99/R00 research project: examining relations among maternal
exposure to nonpersistent EDCs, biomarkers of placental dysfunction, and indicators of maternal
cardiovascular disease both before and after pregnancy. This Pathway to Independence Award will provide the
additional mentorship and expertise I need to transition to faculty and successfully compete for funding as a
principal investigator. My training plan includes formal courses, workshops and seminars, directed readings,
and apprenticeships to develop skills in 1) EDCs, environmental epidemiology, and exposure assessment, 2)
advanced statistical methods, and 3) the intersection between placental and cardiovascular health. In the K99
phase of my research, I will leverage data currently being collected in the New York University (NYU)
Children’s Health and Environment Study (CHES) that includes both prenatal maternal biomarker and
questionnaire data as well as postnatal maternal cardiovascular measures. In the R00 phase, I will incorporate
additional preconception data from the NYU Factors Influencing Reproductive Success and Time to Pregnancy
(FIRST) Study. Specific Aims include 1) examining relations of maternal prenatal urinary phthalate and
bisphenol levels to maternal biomarkers of placental development, and trimester-specific effects of EDCs on
placental size at birth, 2) examining relations of prenatal urinary phthalate and bisphenol levels measured in
three trimesters of pregnancy to maternal clinical cardiovascular risk factors at 1 and 2 years postpartum in
CHES, and 3) assessing relations among maternal preconception phthalate and bisphenol exposure,
preconception cardiovascular risk factors, time to pregnancy, and placental growth and development using
combined CHES and FIRST data. These training and research activities will increase my expertise as an
environmental epidemiologist and prepare me to successfully compete for R01 funding as an independent
investigator with a focus on reproductive and women’s health.
Terms: <0-11 years old><Active Follow-up><Affect><Age><Angiogenesis Antagonists><Angiogenesis Blockers><Angiogenesis Factor><Angiogenesis Inhibitors><Angiogenetic Antagonists><Angiogenetic Inhibitors><Angiogenic Antagonists><Angiogenic Factor><Angiogenic Inhibitors><Angiostatic Agents><Anti-Angiogenetic Agents><Anti-Angiogenic Agents><Anti-Angiogenic Drugs><Antiangiogenesis Agents><Antiangiogenic Agents><Antiangiogenic Drugs><Attention><Award><BMI><BMI percentile><BMI z-score><Biological><Biological Markers><Birth><Birth Weight><Blood Pressure><Blood Serum><Blood Vessels><Blood flow><Body fat><Body mass index><Cardiac Output><Cardiovascular><Cardiovascular Body System><Cardiovascular Diagnostic Technics><Cardiovascular Diagnostic Techniques><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cause of Death><Cells Placenta-Tissue><Chemical Exposure><Chemicals><Child><Child Health><Child Youth><Children (0-21)><Chronic><Clinical><Complex><Conceptions><DEHP><Data><Developing fetus><Di-2-Ethylhexylphthalate><Diabetes Mellitus><Diethylhexyl Phthalate><Dioctyl Phthalate><Dysfunction><EPH Gestosis><Eclampsia><Education><Educational aspects><Educational workshop><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Endothelium><Environment><Environmental Epidemiology><Epidemiologist><Exposure to><FLT VEGF Receptor><FLT1 RTK><FLT1 Receptor Tyrosine Kinase><Faculty><Fecundability><Fecundity><Female Health><Fertility><Fetal Development><Flt-1><Functional disorder><Funding><Generalized Growth><Gestation><Gestational Hypertension><Goals><Growth><Growth and Development><Growth and Development function><Health><Heart Vascular><Hospital Admission><Hospitalization><Hypertension><Hypertension induced by pregnancy><Hypertension-Associated Pregnancy Disorder><Impairment><Incidence><Inflammatory><Investigators><Link><Lipids><Long-Term Effects><Longterm Effects><Maternal Exposure><Maternal and Child Health><Measurable><Measures><Mentorship><Methodology><Mothers><Neonatal Mortality><Neovascularization Inhibitors><New York><Normal Placentoma><Nulliparas><Nulliparity><Nulliparous><Nutrient><Organ><Outcome><PGF gene><PLGF-2><Participant><Parturition><Pathway interactions><Perfusion><Phase><Physiologic pulse><Physiopathology><PlGF><PlGF protein><Placenta><Placenta Embryonic Tissue><Placental Development><Placental Growth Factor><Placentation><Placentome><Plastics><Population><Position><Positioning Attribute><Postpartum Period><Pre-Eclampsia><Preeclampsia><Pregnancy><Pregnancy Associated Hypertension><Pregnancy Complications><Pregnancy Toxemias><Pregnancy Trimesters><Principal Investigator><Proteinuria-Edema-Hypertension Gestosis><Proto-Oncogene Protein flt><Publishing><Pulse><Questionnaires><Quetelet index><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Tyrosine Kinase,Class V><Research><Research Activity><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk><Risk Factors><Semen><Seminal fluid><Serum><Statistical Methods><Tissue Growth><Training><Training Activity><Tyrosine Protein Kinase FRT><Tyrosine Protein Kinase Receptor FLT><United States><Universities><VEGF Receptor flt-1 Protein><VEGFR-1><VEGFR1><Vascular Endothelial Growth Factor Receptor-1><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vascularization><Weight><Woman><Women's Health><Work><Workshop><active followup><advanced maternal age><advanced reproductive age><adverse birth outcomes><after pregnancy><ages><analyzing longitudinal><antiangiogenic><apprentice><apprenticeship><bio-markers><biologic><biologic marker><biomarker><bisphenol A><blood pressure elevation><cardiovascular disease diagnosis><cardiovascular disorder><cardiovascular disorder diagnosis><cardiovascular effects><cardiovascular function><cardiovascular health><cardiovascular risk><cardiovascular risk factor><career><circulatory system><cohort><complications during pregnancy><cytokine><death among neonates><death among newborns><death in neonates><death in newborn><design><designing><diabetes><diethylhexylphthalate><diphenylolpropane><early pregnancy><elevated blood pressure><endocrine disrupting compound><environmental chemical><experience><fetal><fms-Like Tyrosine Kinase><follow up><follow-up><followed up><followup><heart output><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disease of pregnancy><hypertensive disorder><increase in blood pressure><increased blood pressure><kids><longitudinal analysis><maternal serum><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><neonatal death><neonatal demise><neonatal morbidity><newborn death><newborn morbidity><newborn mortality><ontogeny><pathophysiology><pathway><personal care products><phthalates><placenta growth factor><post pregnancy><post-doctoral training><post-partum><postdoctoral training><postnatal><pre-eclamptic><pregnancy disorder><pregnancy hypertension><pregnancy toxemia/hypertension><pregnancy-related complications><prenatal><prepregnancy><product placenta growth factor><recruit><reproductive><reproductive epidemiology><reproductive success><skills><statistic methods><time-to-pregnancy><training module><unborn><urinary><vascular><weights><youngster>