Document text
Principal Investigator: Sixto Manuel Leal
Organization: UNIVERSITY OF ALABAMA AT BIRMINGHAM
Fiscal Year: 2024
Award: $316,700
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary/Abstract:
Core 3 outlines a strategic plan to establish integrated core services within the UAB SEBLAB
enabling safe and efficient use of the cutting edge scientific equipment recently funded by NIAID
award 1G20AI167409-S1. This proposal establishes six functional integrated research cores
within containment including: 1. Cell Culture core to maintain and generate novel cell lines, 2.
Microbiology core to culture organisms, modify, and maintain stocks, 3. In vitro core to operate
high resolution imaging and high-throughput screening platforms, 4. In vivo core to operate high
complexity non-invasive imaging platforms, 5. Single Cell core to perform flow cytometry, cell
sorting, and single cell partitioning, and 6. Pandemic Preparedness core to develop medical
countermeasures and drive IRB-approved high containment research requiring clinical samples.
Each core will be operated by a scientific research team, including the PI on this application,
one senior scientist, and two junior scientists. This scientific team will work closely with UAB
Core lab directors, Biosafety, and SEBLAB end users to optimize high containment research
productivity.
Terms: <Air><Alabama><Anesthesia><Anesthesia procedures><Autopsy><Avian Influenza><Award><Biomedical Research><Bird Flu><CAT scan><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CT X Ray><CT Xray><CT imaging><CT scan><Cell Body><Cell Culture Techniques><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><CellLine><Cells><Clinical><Clinical Evaluation><Clinical Testing><Collaborations><Computed Tomography><Consultations><Containment><Core Facility><Coronaviridae><Coronavirus><Decontamination><Development><Diagnostic tests><Drug Delivery><Drug Delivery Systems><Encephalitis Viruses><Equilibrium><Equine Encephalitis><Equine Encephalomyelitis><Equine Encephalomyelitis Viral Infections><Equine Encephalomyelitis Virus Infections><Equipment><Evaluation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fostering><Fowl Pest><Fowl Plague><Funding><GMO Organisms><Genetically Modified Organisms><Genotype><High Resolution Computed Tomography><High Throughput Assay><Histoplasma><Human><IRB><IRBs><Immune response><Immunological response><Immunology><In Vitro><Individual><Infection><Institutional Review Boards><Investments><Laboratories><Laboratory Research><Light><Liquid substance><Lung><Lung Function Tests><Lung Respiratory System><M tb><M tuberculosis><M. tb><M. tuberculosis><Microbe><Microbiology><Microscopy><Mission><Modern Man><Mycobacterium tuberculosis><NIAID><National Institute of Allergy and Infectious Disease><Nebulizer><Organism><Output><PET><PET Scan><PET imaging><PETSCAN><PETT><Photoradiation><Plaque Assay><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Productivity><Pulmonary function tests><Rad.-PET><Recovery><Research><Research Infrastructure><Research Resources><Research Support><Resolution><Resources><Risk><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SPECT><SPECT imaging><Sampling><Scientist><Senior Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Single-Photon Emission-Computed Radionuclide Tomography><Solid><Strains Cell Lines><Strategic Planning><System><Technology><Tomodensitometry><Translating><Translational Research><Translational Science><Universities><Variant><Variation><Venezuelan Equine Encephalitis><Venezuelan Equine Encephalomyelitis><Venezuelan Equine Fever><Virus><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><animal imaging><avian flu><avian strains of influenza><balance><balance function><biobank><biocontainment facility><biocontainment lab><biocontainment laboratory><biodefense><bioluminescence imaging><bioluminescent imaging><biorepository><career preparation><career readiness><catscan><cell culture><cell cultures><cell sorting><chikungunya><clinical test><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><consultation><corona virus><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cultured cell line><developmental><emergent pandemic><emerging pandemic><exhaust><experiment><experimental research><experimental study><experiments><facilities for imaging><flow cytophotometry><fluid><fluorescence imaging><fluorescent imaging><fungus><future outbreak><future pandemic><genetically engineered cells><genetically modified cells><high resolution CT><high resolution imaging><high throughput screening><host response><imaging center><imaging facilities><imaging in vivo><imaging platform><imaging-related facilities><immune system response><immunoresponse><in vitro Assay><in vivo><in vivo imaging><influenza in birds><innovate><innovation><innovative><insight><job readiness><liquid><live cell image><live cell imaging><live cellular image><live cellular imaging><living system><medical countermeasure><microbial><mtb><nebulization><nebulize><necropsy><new pandemic><next outbreak><next pandemic><non-contrast CT><non-invasive imaging><noncontrast CT><noncontrast computed tomography><noninvasive imaging><novel><novel pandemic><operation><operations><outbreak in the future><pandemic concern><pandemic disease preparedness><pandemic planning><pandemic potential><pandemic preparedness><pandemic readiness><pandemic risk><pandemic threat><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><postmortem><pulmonary><repair><repaired><research clinical testing><resolutions><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><single cell analysis><single photon emission computed tomography><skills><super high resolution><superresolution><tissue processing><translation research><translational investigation><ultra high resolution><work readiness><workforce readiness><workplace readiness>