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Principal Investigator: JAMES M WACHIRA
Organization: MORGAN STATE UNIVERSITY
Fiscal Year: 2024
Award: $833,146
Funding agency: National Institute on Minority Health and Health Disparities
PROJECT SUMMARY – Research Capacity Core
The proposal aims to provide resources and expertise to enhance biomedical research quality and productivity
through a Morgan State University (MSU) RCMI Research Capacity Core (RCC). With current funding support
by NIMHD/RCMI and NIH/NIGMS/BUILD, MSU has established three biomedical core facilities as follows: (a) A
Molecular and Cellular Biology Core (MCB) that offers routine and advanced research instrumentation and
training in a diversity of research technologies; (b) An Animal Research Facility (ARF) that has obtained NIH
OLAW assurance and provides consultation, training, and animal care; and (c) A Biostatistics and Bioinformatics
Support Unit (BBSU) that provides consultation and training in quantitative research methods. Based on reviews,
project evaluations, user feedback, and the projected research directions (including RCMI research projects and
pilot projects), we propose to further enhance the resources and services through the following specific aims: (1)
acquire research instrumentation and technologies to enhance the research capacity of the existing Cores and
thereby increase research quality and productivity at MSU; (2) revamp current management structures and
institute cost recovery systems to further institutionalize the resources and engender long-term sustainability;
and (3) facilitate collaborations between researchers across disciplines and institutions with a view of promoting
impactful team science. Under the proposed scope, instrumentation will be purchased to meet the needs of the
three proposed RCMI projects, planned pilot projects, and other research projects at the university. New
equipment for genomics and genetics analyses will support the proposed basic biomedical research project and
the behavioral research project. The current cell analysis capabilities will be expanded with the acquisition of a
benchtop flow cytometer capable of multiplex fluorophores to support the behavioral research project, pilot
projects, and ongoing projects on cancer and cell biology. Data analysis and archiving will be expanded with the
purchase of computers and relevant software to allow HIPAA-compliant informatics to meet the needs of the
behavioral research project and clinical project. The RCC will strengthen core laboratory management practices
by implementing new laboratory management software and drawing on more faculty expertise. A sustainability
plan will include cost-recovery efforts and continued institutionalization of some RCC functions. The BBSU will
promote the use of national data such as All of Us data and promote engagement with the NIH Clinical and
Translational Sciences Award (CTSA) programs. In collaboration with the Investigator Development Core and
Community Engagement Core, the RCC will support pilot and community-based projects. The RCC will also
engage the Baltimore community in education, research, and disseminate current scientific advances related to
healthy urban communities through the Community Engagement Core. The RCC will incorporate evaluation
feedback on an ongoing basis. In sum, these objectives will increase health disparities research output as
measured by research publications, grant awards, and the training of students.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Animal Model><Animal Models and Related Studies><Archives><Area><Award><Baltimore><Basic Research><Basic Science><Behavioral Research><Behavioral Sciences><Bio-Informatics><Biocompatible Materials><Bioinformatics><Biology><Biomaterials><Biomedical Research><Biometrics><Biometry><Biostatistics><COVID-19 virus><COVID19 virus><Cancer Biology><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Clinical><Clinical Research><Clinical Study><Clinical and Translational Science Awards><CoV-2><CoV2><Collaborations><Communicable Diseases><Communities><Computer software><Computers><Consult><Consultations><Core Facility><Data><Data Analyses><Data Analysis><Data Collection><Decrease health disparities><Development><Discipline><Education><Educational aspects><Ensure><Environmental Health><Environmental Health Science><Equipment><Evaluation><Faculty><Feedback><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Funding><Genetic analyses><Genomics><Goals><Grant><HIPAA><Health Disparities Research><Health Insurance Portability and Accountability Act><Health disparities related research><Health disparity mitigation><Health disparity reduction><Heart Vascular><Human><Immune><Immunes><Immunomodulation><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Informatics><Institution><Institutionalization><Investigators><Kennedy Kassebaum Act><Laboratories><Laboratory Animal Production and Facilities><Laboratory Research><Lower health disparities><Maintenance><Malignant Neoplasms><Malignant Tumor><Manuscripts><Maryland><Measurement><Measures><Memory><Microscopy><Mitigate health disparities><Modern Man><Molecular><Molecular and Cellular Biology><NCMHD><NIGMS><NIH><NIMHD><National Center on Minority Health and Health Disparities><National Institute of General Medical Sciences><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><National Institutes of Health><Neurosciences><Output><PL 104-191><PL104-191><Patients><Performance><Pilot Projects><Practice Management><Process><Productivity><Public Law 104-191><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Reduce health disparities><Research><Research Activity><Research Animal Facility><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Project Summaries><Research Projects><Research Resources><Researchers><Resources><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Schedule><Science><Scientific Advances and Accomplishments><Scientific Publication><Secure><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Software><Stress><Structure><Subcellular Process><System><Technical Expertise><Technology><The Jackson Laboratory><Training><United States Health Insurance Portability and Accountability Act><United States National Institutes of Health><Universities><Urban Community><Wuhan coronavirus><animal care><archive data><archiving data><biological material><catalyst><cell biology><circulatory system><community engagement><consultation><consults><coronavirus disease 2019 virus><coronavirus disease-19 virus><cost><cost effectiveness><data access><data archive><data archives><data interpretation><data management><developmental><digital><engagement with communities><epigenetic regulation><flow cytophotometry><fluorophore><genetic analysis><hCoV19><health disparities science><human data><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improve minority health><improved><improvement of minority health><innovate><innovation><innovative><instrument><instrumentation><malignancy><model of animal><nCoV2><nanomaterials><neoplasm/cancer><nutrition><open source><pilot study><programs><research and methods><scientific accomplishments><scientific advances><student training><success><synergism><technical skills><urban health disparities>