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Principal Investigator: Christopher Lee Baker
Organization: JACKSON LABORATORY
Fiscal Year: 2024
Award: $20,000
Funding agency: NIH Office of the Director
PROJECT SUMMARY
Research and experimental use of pluripotent stem cells has expanded rapidly, and these cells now provide
important research models of human disease and personalized regenerative medicine. However, the majority of
research to date that has utilized stem cells has employed genetically-limited murine cells or clonal human cell
lines with little attention paid to the impact of cellular genetic diversity on the phenotypic and functional outcomes
and its relevance to human diversity. Importantly, recent data from murine and human studies of pluripotent stem
cells indicate that genetic variability is the most significant driver of molecular and cellular differences in
phenotype, including the ease of establishment of pluripotent cell lines, the rate of spontaneous differentiation,
reprogramming differentiated cells to a pluripotent state, and the future use of stem cells as personalized
therapeutics. Thus, there is now an unmet need, not rigorously addressed at current conferences, to understand
the consequences of genetic variation on stem cell biology and their impact on development. To fill this gap, we
propose the unique and timely conference “Diversity in a Dish: Pluripotent Stem Cells in Genetic Analysis and
Disease Modeling” to facilitate interdisciplinary interactions and collaborations between experts in mouse and
human genetics, cell biology, and pluripotency, and to engage diverse learners who are the next generation of
stem cell researchers. We propose an annual, intensive 3-day conference beginning in 2023 at The Jackson
Laboratory in Bar Harbor, ME. We will bring together 50 scientists, spanning career stages, from the fields of
genetics, cell biology, and pluripotency, as well as provide a virtual attendance option for those that cannot or
choose not to attend in person. For Aim 1, we will convene an interdisciplinary symposium organized around
cutting-edge research seminars, workshops that focus on technical skill acquisition, and rigor and reproducibility
as applied to stem cell research and genomic analyses. In Aim 2, we will promote interactive and inclusive
activities, to promote networking, mentorship, learner involvement, collaborative research, and career
development. These activities include trainee presentations and short talks, and evening discussions focused
on research projects, rigor and ethics, and grantsmanship. These objectives are facilitated by the residential
nature of the JAX Highseas Conference Center. In Aim 3, we will promote diversity in both the recruitment of
participants and in the tools being generated to study models of human disease. Diverse attendees will be
actively recruited, scholarships will be provided to enable in-person attendance, and an inclusive virtual option
will enable participation by those that are unable to travel. Diversity will also be emphasized in the context of
best practices for research, including the need for studies of genetically diverse panels of stem cells, and fair
acquisition, representation, and distribution of cell lines from wider representation of backgrounds to ensure the
benefits discovered from these biomedical resources are shared equitably.
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groups><underrepresented people><unequal group><unequal population><virtual><whole genome association analysis><whole genome association studies><whole genome association study>