Document text
Principal Investigator: Jerica M Berge
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2024
Award: $549,281
Funding agency: National Heart Lung and Blood Institute
ABSTRACT
Food insecurity is known to be associated with metabolic and cardiovascular disease in adults. However, there
is a gap in our knowledge; specifically a lack of studies investigating factors that influence the emergence of
cardiometabolic risks from food insecurity during childhood and adolescence. An improved understanding of
the role of timing and severity of food insecurity on children’s cardiometabolic health (CMH), the
mechanisms/pathways between food insecurity and CMH, and the factors that buffer against or exacerbate this
risk are needed to inform intervention development to prevent later cardiometabolic disease amongst children
who are food insecure. The main objective of this prospective study is to understand how cardiometabolic risk
arises from food insecurity during childhood and identify malleable factors for intervention to buffer the negative
health impact of food insecurity on adolescent’s CMH. We will leverage an established cohort of
racially/ethnically diverse children from low-income households (n=627) participating in a prospective,
longitudinal study examining childhood obesity disparities (HL126171: Berge PI). Survey and ecological
momentary assessment (EMA) data have already been collected, including measures of food insecurity,
household environment (e.g., food environment, family functioning), child health behavior (e.g., diet quality,
sleep, physical activity) and parent behaviors (e.g., feeding practices, stress, coping) at two time points (~24
months apart) at ages 5-10. New measures proposed at ages 11-16 will include: (1) measures of CMH (Life’s
Simple 7 and state-of-the-science measures of body composition, metabolic and cardiovascular function,
oxidative stress and inflammation (i.e., cytokines)), (2) Geographical Information Services (GIS) data, and (3)
focus groups with families, school representatives, community organizations, and healthcare providers to
identify intervention targets and refine policies to reduce harmful health effects of food insecurity. Specifically,
this state-of-the art study will: (1) determine the impact of exposure to household food insecurity (i.e., severity,
timing) on child/adolescent CMH; (2) identify mechanisms/pathways between food insecurity and CMH; (3)
evaluate the extent to which child behaviors, parent factors, and access to resources impact the relationship
between food insecurity and CMH; and (4) using mixed-methodologies (biomarkers, focus groups, EMA, GIS),
prospectively examine the dynamics (e.g., severity, timing) of household food insecurity throughout childhood
and adolescence, and identify risk and protective factors at the level of the family, neighborhood, school, and
community to inform intervention and policy development. This approach is innovative because it represents a
departure from the status quo by focusing on when and how cardiometabolic risk emerges from food insecurity
during childhood and the multi-level factors which buffer against or exacerbate this risk, and significant
because it is expected to have implications for intervention development to prevent future cardiometabolic
diseases among adolescents from food insecure households.
Terms: <0-11 years old><12-20 years old><21+ years old><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent obesity><Adult><Adult Human><Aeroseb-HC><Affect><Age><Biological Markers><Body Composition><Body Measures><Body fat><Body measure procedure><Buffers><COVID-19><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><CV-19><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Cardiovascular Physiology><Cetacort><Child><Child Behavior><Child Health><Child Rearing><Child Youth><Childhood><Children (0-21)><Communities><Coronavirus Infectious Disease 2019><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Dermacort><Development><Diet><Disparities><Disparity><Dysfunction><Ecological momentary assessment><Eldecort><Environment><Exposure to><Family><Focus Groups><Food><Functional disorder><Future><Geography><Health><Health Care Providers><Health Personnel><Health behavior><Healthcare><Healthcare Providers><Healthcare worker><Household><Hydrocortisone><Hydrocortone><Hytone><Individual><Inflammation><Information Services><Intervention><Intervention Strategies><Knowledge><Life><Long-term prospective studies><Longterm prospective studies><Low income><Measurement><Measures><Mediating><Mediator><Metabolic><Metabolic Diseases><Metabolic Disorder><Methodology><Methods><Morbidity><Morbidity - disease rate><Neighborhoods><Nutracort><Obesity><Oxidative Stress><Parenting><Parenting Education><Parenting behavior><Parents><Pathway interactions><Personal Satisfaction><Physical activity><Physiology><Physiopathology><Policies><Policy Developments><Price><Proctocort><Prospective Studies><Puberty><Public Health><Research Resources><Resources><Risk><Risk Factors><Role><Schools><Science><Secure><Severities><Sleep><Staging><Stress><Stressful Event><Structural Racism><Survey Instrument><Surveys><Thesaurismosis><Time><adiposity><adolescence (12-20)><adulthood><ages><bio-markers><biologic marker><biomarker><cardiometabolic><cardiometabolic risk><cardiometabolism><cardiovascular disorder><cardiovascular function><child adiposity><child obesity><childhood adiposity><childhood obesity><childrearing><cohort><community based organizations><community organizations><community setting><coping><coronavirus disease 2019><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><coronavirus disease-19><coronavirus infectious disease-19><corpulence><cytokine><design><designing><develop therapy><developmental><dietary><diets><economic impact><effects following the COVID-19 pandemic><ethnic diversity><ethnically diverse><experience><feeding><food environment><food insecurity><health care><health care personnel><health care worker><health provider><health related behavior><health workforce><healthcare personnel><impact of the SARS-CoV-2 pandemic><improved><innovate><innovation><innovative><intervention development><interventional strategy><juvenile><juvenile human><kids><longitudinal, prospective study><medical personnel><metabolism disorder><mortality><nutrition><obese adolescents><obese children><obesity among adolescents><obesity during adolescence><obesity during childhood><obesity in adolescence><obesity in adolescents><obesity in children><obesity risk><pandemic><pandemic disease><parent><pathophysiology><pathway><pediatric><pediatric obesity><prevent><preventing><pricing><prospective><protective factors><racial diversity><racially diverse><risk for obesity><risk of obesity><social role><stressful experience><stressful life event><stressful life experience><therapy development><treatment development><treatment provider><well-being><wellbeing><youngster><youth adiposity>