Document text
Principal Investigator: Thomas Carpino
Organization: JOHNS HOPKINS UNIVERSITY
Fiscal Year: 2024
Award: $48,974
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY/ABSTRACT
Specific Aims: The overarching goal of this proposed study is to assess the factors associated with
monkeypox (MPOX) vaccination, testing, and stigma amongst men who have sex with men (MSM) in the
United States (US). Specially, we aim to 1. Evaluate determinants and disparities of MPOX vaccination
amongst MSM; 2. Characterize differences in MPOX testing uptake amongst MSM with MPOX-like symptoms;
3. Develop MPOX-specific stigma measures to evaluate the impacts of MPOX-related stigma amongst MSM.
Significance: Since May 2022, MPOX has been declared a public health emergency of international concern
with over 86,700 cases of MPOX in 110 countries/territories. Due to its widespread and rapid incidence, its
threat of endemicity or re-emerging outbreaks is significant. There is a growing but scarce body of literature
related to MPOX, with many unanswered questions related to disparities and determinants of vaccination,
testing, and stigma and how this will change in the coming years. Gay men have historically faced adverse
health effects compared to other reproductive aged adults, as witnessed in the global HIV/AIDS epidemic.
Furthermore, the emergence of COVID-19 has influenced accessibility of sexual health services and public
perception of infectious diseases, which could be leveraged to inform public health responses for MPOX and
future threats.
Approach: We will leverage data from approximately 10,000 MSM in the United States between 2022-2023
who participated in the American Men’s Internet Survey (AMIS). This proposed study is a rapid response to the
MPOX Epidemic using an innovative approach to understand trends and address unsolved questions in the
public health response. These data allow for assessment of higher level, contextual effects through developing
consistent metrics, to perform exploratory factor analysis and multilevel analysis of individual heterogeneity
and discriminatory accuracy (MAIHDA).
Training Information: Mr. Carpino’s training will consist of advanced infectious disease epidemiological
methodologies and social and behavioral factors. He will also incorporate contextual and structural level factors
and incorporate large data sources to apply analysis methods of observational data.
Terms: <21+ years old><AIDS Virus><AIDS/HIV><Abate><Access to Information><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adult><Adult Human><Affect><Age><American><Anxiety><Awareness><Behavior><Behavioral><Bi-sexual><Biologic Factor><Biological><Biological Factors><Bisexual><COVID-19><CV-19><Central Africa><Cessation of life><Chills><Clinical><Collaborations><Communicable Diseases><Communication><Communities><Constitutional Finding><Constitutional Symptom><Coronavirus Infectious Disease 2019><Country><Data><Data Sources><Death><Disparities><Disparity><Dose><Drug usage><Epidemic><Epidemiologic Determinants><Epidemiologic Factors><Epidemiological Factors><Epidemiology><Ethnic Origin><Ethnicity><Exanthem><Exanthema><Factor Analyses><Factor Analysis><Fever><Future><Gays><Goals><HIV><HIV/AIDS><Health><Health Services><Healthcare><Human><Human Immunodeficiency Viruses><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Incidence><Individual><Infection><Infectious Disease Epidemiology><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infectious Epidemiology><International><Internet><Knowledge><LAV-HTLV-III><Lesion><Literature><Logistic Regressions><Lymphadenopathy-Associated Virus><MSM><Measures><Mental Depression><Mentorship><Methodology><Methods><Modeling><Modern Man><Monkey Pox><Monkey Pox Virus><Monkeypox><Monkeypox virus><Monkeypoxvirus><Orthopox virus><Orthopoxvirus><Outcome><Pain><Painful><Perception><Persons><Policies><Population><Position><Positioning Attribute><PrEP><Prevention><Property><Psychological Factors><Psychometrics><Public Health><Pyrexia><Race><Races><Rash><Recurrence><Recurrent><Reporting><Research><Risk><Risk Factors><Sexual Health><Skin Rash><Stigmatization><Structural Racism><Subgroup><Survey Instrument><Surveys><Symptoms><Target Populations><Techniques><Testing><Training><Transmission><United States><Universities><Vaccination><Vaccines><Virus><Virus-HIV><WWW><Work><Zoonoses><Zoonotic><Zoonotic Infection><accept vaccination><accept vaccine><access disparities><access to health care><access to healthcare><access to vaccination><access to vaccines><accessibility disparities><accessibility of health care><accessibility to health care><accessibility to healthcare><adulthood><aged><ages><biologic><cis-gender man><cis-male><cis-man><cisgender man><community factor><community-level factor><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><depression><disparities in access><disparities in race><disparity due to race><disparity in health><drug use><emergent outbreak><emerging outbreak><epidemiologic><epidemiological><experience><febrile><febris><health care><health care access><health care availability><health care service><health care service access><health care service availability><health disparity><healthcare access><healthcare accessibility><healthcare availability><healthcare service><healthcare service access><healthcare service availability><immunosuppressed patient><individual heterogeneity><individual variability><individual variation><inequality due to race><inequality in access><inequity due to race><inequity in access><inequity in accessibility><innovate><innovation><innovative><marginalization><member><men><men having sex with men><men who have sex with men><men who have sex with other men><methods to study multiple-level influences><mortality><mpox><mpox virus><mpxv><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><new outbreak><novel outbreak><outreach to information><pre-exposure prophylaxis><psychologic><psychological><public health emergency><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racially unequal><reproductive><response><social><social stigma><socio-demographics><sociodemographics><stigma><study population><testing services><testing uptake><transmission process><treatment services><trend><uptake><vaccination acceptability><vaccination acceptance><vaccination access><vaccination availability><vaccination confidence><vaccination uptake><vaccination willingness><vaccine acceptability><vaccine acceptance><vaccine access><vaccine availability><vaccine confidence><vaccine uptake><vaccine willingness><web><world wide web>