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Principal Investigator: Mai ElMallah
Organization: DUKE UNIVERSITY
Fiscal Year: 2024
Award: $308,524
Funding agency: National Heart Lung and Blood Institute
ABSTRACT / PROJECT SUMMARY
In response to a 30-year decline in the number of physician-scientists, attributed to prolonged clinical training,
doubling or tripling of education debt, uncertain grant funding prospects, unclear career trajectories, and a lack
of mentored research opportunities during early clinical training, the NIH started the Mentored ResearchPathway
in Residency R38 program. Residency training, a critical step in physician training, is often carried out by training
programs that do not support physician-scientist development. Significant gaps exist for protected research
time, structured trainingand mentoring, and support to continue researchafter returningto the clinic. The primary
goal of the multidisciplinary Duke NHLBI Scientist-Clinician-Investigator Stimulating access to Research during
Residency (Duke SCI-StARR) program is to train a diverse cadre of physician-scientists who will lead the
development, implementation, and evaluation of new clinical modalities to prevent, diagnose, and treat disease
states affecting the heart, lungs, and blood throughout the life-course. Duke NHLBI SCI-StARR trainS residents
across 3 departments: Pediatrics, Medicine, and Surgery in areas along the full biomedical research
continuum (basic/translational, early phase clinical trials and pharmacokinetics, and late phase clinical
trials and outcomes) with a theme of improving health over the life course. The program will consist of four
training aims: 1) comprehensive didactics covering basic, translational, and clinical research and professional
development; 2) development and completion of a research project and an individualized career development
plan; 3) establishment of a track record of scholarly activity; and 4) eligibility for board certification and
continuation to subspecialty training. Duke NHLBI SCI-StARR will be led by an Executive Committee (EC) of
MPIs Mai K. ElMallah, MD (Pediatrics), Scott Palmer, MD, MHS (Medicine), and David Harpole, Jr., MD
(Surgery), and an Expanded EC of Residency Program Directors and Program Coordinators, capitalizing on a
team of 33 multi-departmental, multi-disciplinary, well-funded, and experienced faculty preceptors. This
application requests support for three Resident-Investigators each year with each trainee to be supported for 18-
24 months of research. Upon completion of the program, these individuals will be capable of transitioning to
research-intense fellowship training, successfully competing for extramural funding to support a path to
independence as physician-scientists, and becoming the next generation of physicians leading and mentoring
trainees in clinically-oriented research of disease states affecting the heart, lungs, and blood. Achievement of
the program's objectives will fulfill urgent medical needs for: 1) more full-time academic physician-researchers
and mentors in medical schools throughout the country and 2) innovations and clinical translation of novel
strategies to improve the health of individuals across the life course.
Terms: <Achievement><Achievement Attainment><Address><Affect><Applications Grants><Area><Award><Basic Research><Basic Science><Biomedical Research><Blood><Blood Diseases><Blood Reticuloendothelial System><Blood Vessels><Board Certification><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><Cardiac Diseases><Cardiac Disorders><Cardiopulmonary><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Caring><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical><Clinical Research><Clinical Study><Clinical Trials><Communication><Communities><Country><Critiques><Data Science><Dedications><Development><Development Plans><Diagnosis><Disease><Disorder><Disparities><Disparity><Drug Kinetics><EXTMR><Education><Educational aspects><Educational workshop><Eligibility><Eligibility Determination><Ensure><Evaluation><Extramural><Extramural Activities><Faculty><Fellowship><Fostering><Foundations><Funding><Goals><Grant><Grant Proposals><Health><Healthcare><Heart><Heart Diseases><Heart Vascular><Hematologic Diseases><Hematological Disease><Hematological Disorder><Human><Individual><Infrastructure><Institution><Intracellular Communication and Signaling><Investigators><Journals><Laboratory Research><Life Cycle><Life Cycle Stages><Lung><Lung Diseases><Lung Respiratory System><Magazine><Manuscripts><Medical><Medicine><Mentors><Mentorship><Methods><Mission><Modality><Modern Man><Modernization><NHLBI><NIAID><NIH><NIH RFA><National Heart, Lung, and Blood Institute><National Institute of Allergy and Infectious Disease><National Institutes of Health><Operative Procedures><Operative Surgical Procedures><Outcome><Pathway interactions><Pediatrics><Peer Review><Pharmacokinetics><Phase><Physicians><Physicians' Offices><Position><Positioning Attribute><Productivity><Protocol Screening><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Request for Applications><Research><Research Grants><Research Personnel><Research Priority><Research Project Grants><Research Projects><Research Resources><Research Training><Researchers><Residencies><Resources><Scholarship><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Structure><Study Section><Surgical><Surgical Interventions><Surgical Procedure><Time><Training><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Work><Workshop><Writing><biological signal transduction><blood disorder><career><career development><circulatory system><clinical training><clinical translation><clinically translatable><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease-19 impact><developmental><disease of the lung><disease prevention><disorder of the lung><disorder prevention><early clinical trial><early phase clinical trial><experience><health care><health data><heart disorder><implementation research><improved><innovate><innovation><innovative><life course><lung disorder><medical college><medical schools><meeting><meetings><multidisciplinary><new approaches><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><next generation diagnostics><novel approaches><novel diagnostics><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><pediatric department><preference><prevent><preventing><programs><public health relevance><pulmonary><response><school of medicine><skills><success><surgery><tool><translation research><translational investigation><vascular>