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Principal Investigator: ROBERT A CLARK
Organization: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Fiscal Year: 2024
Award: $5,584,747
Funding agency: National Center for Advancing Translational Sciences
Project Summary-Abstract
South-Central Texas is home to San Antonio and Austin, both among the nation’s
fastest growing cities. San Antonio, the gateway to South Texas, is the 7th largest city and the largest minority-
majority Hispanic/Latino city in the US, whereas Austin is 11th largest. The region also includes many rural
counties and several on the US-Mexico border. Given our demographics and rapid growth, our area foreshadows
future challenges facing US healthcare, underscoring the national applicability of solutions devised by our hub.
In 2006, UT Health Science Center San Antonio established the Institute for Integration of Medicine &
Science (IIMS) as the academic home for translational research initiatives, training the translational science
workforce, formalizing key strategic partnerships, and creating a community of scholars within a learning
healthcare system. Building upon our optimized clinical and translational research infrastructure, IIMS now
proposes a 4th cycle of CTSA support in response to PAR-21-293. Our hub seeks to be exceptional in solving
clinical and translational science (CTS) roadblocks, translating discoveries into reduced disparities and improved
healthcare outcomes across our multi-cultural population. We strive to make our vision a reality through robust
strategies for supporting CTS across institutional partners and collaborating organizations, catalyzing successes
for transdisciplinary research teams, and implementing programs that produce a creative, collaborative, and
culturally diverse translational science workforce. We will achieve our goals through the strategic deployment of
resources and expertise developed during 3 cycles of CTSA funding. Our proposal leverages optimized strengths
across the spectrum of clinical and translational research to establish the capacity and infrastructure required for
high-impact CTS programs. Thus, IIMS will pivot from the study of specific targets/diseases (i.e., clinical
translational research) to the discovery of generalizable principles that apply to many targets/diseases (CTS),
addressing rate-limiting steps and transforming translation from an empirical process into a predictive science.
This guiding tenet is embedded within each Element and Module of this proposal, as well as across our pipeline
of training and workforce development programs. We posit that synergies across hub partners will yield CTS
innovations and contribute meaningfully to the National CTSA Consortium. Our over-arching Specific Aims are:
1. Catalyze the acceleration of CTS discovery and health disparities impact within a vibrant academic home
synergistically integrated with our strategic partners and actively engaged with our diverse communities
2. Capitalize on our extraordinary Hispanic and military/veteran population base to diversify and enhance
our interdisciplinary clinical and translational science workforce
3. Implement innovative strategies for evaluation and continuous improvement across all IIMS programs
4. Focus strategically on dissemination and implementation of evidence-based CTS advances with high
potential for advancing health equity, both regionally and across the National CTSA Consortium
Terms: <Acceleration><Address><Area><Armed Forces Personnel><Automation><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cities><Clinical Research><Clinical Sciences><Clinical Study><Clinical effectiveness><Collaborations><Communities><Community Health Aides><Creativeness><Data><Decrease disparity><Discipline><Disease><Disorder><Dissemination and Implementation><Education and Outreach><Effectiveness><Elements><Emergencies><Emergency Situation><Emergency response><Evaluation><Faculty><Fostering><Funding><Future><Generalized Growth><Goals><Growth><Health><Health Care Systems><Health Informatics><Health Priorities><Health Sciences><Healthcare><Healthcare Systems><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Home><Human><Human Resources><Inequity><Informatics><Infrastructure><Institution><Instruction and Outreach><Intervention><Intervention Strategies><Knowledge><Latino><Leadership><Learning><Lower disparity><Manpower><Measurable><Medicine><Methods><Mexico><Military><Military Personnel><Minority><Mission><Modern Man><Outcome><Patients><Personal Satisfaction><Population><Process><Program Development><Public Health Informatics><Research><Research Infrastructure><Research Priority><Research Resources><Resources><Rural Population><Rural group><Rural people><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Science><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sight><South Texas><Testing><Texas><Tissue Growth><Training><Training Support><Training and Outreach><Translating><Translational Research><Translational Science><Translations><Tutoring and Outreach><Vision><Work><Workforce Development><barrier to translation><care outcomes><clinical practice><clinical translation><clinically translatable><community health worker><consumer informatics><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><creativity><data quality><demographics><disparate effect><disparate impact><disparate result><disparity in health><disparity reduction><dissemination science><diversity and inclusion><diversity and inclusivity><evidence base><flexibility><flexible><health care><health care outcomes><health disparity><health equity><healthcare outcomes><homes><implementation science><improved><inequitable effect><inequitable impact><inequitable outcome><innovate><innovation><innovative><interventional strategy><military population><military veteran><mitigate disparity><novel><obstacle to translation><ontogeny><opiate crisis><opioid crisis><opioid epidemic><outcome disparities><outcome inequality><outcome inequity><personnel><population based><process improvement><programs><rapid growth><reduce disparity><reduction in disparity><resilience><resilient><response><rural counties><rural individual><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><success><synergism><translation><translation barrier><translation obstacle><translation research><translational barrier><translational investigation><translational obstacle><unequal effect><unequal impact><unequal outcome><veteran population><visual function><well-being><wellbeing>