Effects of Altering Social Connectedness on Health
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Principal Investigator: Brenda McCowan Organization: UNIVERSITY OF CALIFORNIA AT DAVIS Fiscal Year: 2024 Award: $682,055 Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development Project Summary Social life profoundly influences health. The ability to treat and prevent illness and improve human health therefore requires a detailed understanding of the complex mechanisms underlying the influence of social complexity on biological systems. Such understanding is key to the development of new interventions to improve public health. Past studies have demonstrated the critical contribution of social relationships in shaping health outcomes but are limited in application because such studies rarely consider social support or health as “complex systems”. As a result, we lack a deep understanding of how and why individuals within families, and families within communities, remain healthy or become unhealthy in the context of their social environments. In this application, our proposed research overcomes this limitation by adopting an intervention- based experimental and computational systems science approach that provides methods uniquely suited to elucidate the complex mechanisms by which social systems influence health by modeling short- and longer term integrative effects of social life on health in a proven nonhuman primate model. Terms: <Address><Adopted><Affect><Appetite><Biological Markers><Cardiovascular Physiology><Communities><Complex><Desire for food><Development><Disease><Disorder><Exhibits><Family><Future><Goals><Health><Human><Immune><Immunes><Individual><Intervention><Intervention Strategies><Kidney><Kidney Urinary System><Life><Link><Liver><Long-Term Effects><Longterm Effects><Measures><Medical Research><Methods><Modeling><Modern Man><Organism-Level Process><Organismal Process><Outcome><Pathway interactions><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Physiology><Play><Population><Position><Positioning Attribute><Prevention><Primary Prevention><Process><Public Health><Research><Research Resources><Resources><Role><Science><Series><Shapes><Social Environment><Social Interaction><Social Network><Social support><Source><System><Testing><Time><Translations><bio-markers><biologic marker><biological systems><biomarker><cardiovascular function><design><designing><developmental><disease risk><disorder risk><efficacious intervention><experience><experiment><experimental research><experimental study><experiments><hepatic body system><hepatic organ system><improved><interventional strategy><motherhood><non-human primate><nonhuman primate><pathway><prevent><preventing><renal><social><social climate><social context><social influence><social interventions><social relationships><social role><social support network><socioenvironment><socioenvironmental><translation>