Document text
Principal Investigator: Raymond Paul Goodrich
Organization: COLORADO STATE UNIVERSITY
Fiscal Year: 2023
Award: $1,338,439
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary: The BSL3 suites in the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at
Colorado State University (CSU) have been operational and at capacity since being commissioned. These
facilities support research in response to new threats from established pathogens, such as Mycobacterium
spp. (tuberculosis, leprosy, and emerging diseases caused by non-tuberculosis mycobacteria) and high
consequence, select agent pathogens, such as Eastern Equine Encephalitis Virus, Venezuelan Equine
Encephalitis, Francisella tularensis, and Burkholderia pseudomallei. The RMRBL BSL3 is required to pivot and
rapidly respond to new, emerging pathogens with pandemic potential. The RMRBL has been exemplary,
researching new threats such as MERS-CoV, MPox, and SARS-CoV-2. The RMRBL BSL3 thus represents the
backbone of research capabilities in infectious disease at CSU. CSU, in turn has supported the facility for the
past 15 years. CSU’s support includes much of the day-to-day operating costs of the RMRBL BSL3 facilities;
remaining costs are covered by assessing user fees to CSU researchers based on square footage and entries.
Expenses beyond day-to-day operational costs, including non-annual facilities repairs and replacement
upgrades require additional advocating and are addressed when eminently needed. This disrupts crucial
operations. Work within the BSL3 comes with a sacrifice to personal comfort due to the requirements for
biosafety and biosecurity, along with the inherent risk of work on high consequence pathogens. Maintaining
safe, operational and appropriate scientific instruments is challenged as servicing these instruments is difficult
and frequently results in the need to replace equipment. The consequence of the cost, work environment,
deprecating equipment and operational disruptions is our inability to maintain a trained workforce and
sufficiently technically equipped BSL3 ‘warm ready’ space. In response to this challenge, we propose our Core
1 – Facility Management, Maintenance & Operations. This core is strategically designed to resolve many of the
RMRBL BSL3 challenges through three functional aims; Aim 1 - Management, will improve upon the current
structure for communication across research and support teams; Aim 2 – Maintenance, will maintain the
RMRBL BSL3 facilities functionality through proactive preventative maintenance, reducing unplanned
disruptions; and finally, Aim 3 – Operations, will institute dedicated operational and animal husbandry support
and improve IT-communications within the RMRBL BSL3/ABSL3. Our comprehensive approach to improving
the management, maintenance, and operations of the RMRBL BSL3 will result in an improved RMRBL BSL3
system that exemplifies communication and collaboration across our diverse leadership and research teams in
a biosafe and bio-secure compliant environment. As a result, the penultimate goal of this core - to perpetuate
warm ready RMRBL BSL3 facilities; compliant with the dynamic requirements for biosafety and biosecurity,
appropriately resourced, and responsive to our national and state RBL mission – will be achieved.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Academia><Address><Administrative Supplement><Advocate><Aging><Animal Husbandries><Animal Husbandry><Award><B pseudomallei><B. pseudomallei><BSL-3 facility><BSL3 facility><Basic Research><Basic Science><Biologic Sciences><Biological><Biological Sciences><Bioscience><Burkholderia pseudomallei><COVID-19 virus><COVID19 virus><Calibration><Capital><Career Choice><Career Path><Categories><Certification><Client><CoV-2><CoV2><Collaborations><Colorado><Communicable Diseases><Communication><Conflict><Conflict (Psychology)><Cyclic GMP><Data><Data Systems><Dedications><Discipline><Disease><Disorder><EEE Virus><Eastern Equine Encephalitis Virus><Eastern Equine Encephalomyelitis Virus><Economic Burden><Education><Educational aspects><Emerging Communicable Diseases><Emerging Infectious Diseases><Ensure><Entrepreneurial Skill><Entrepreneurship><Environment><Equipment><Evaluation><F tularensis><F tularensis infection><F. tularensis><F. tularensis infection><Fees><Foundations><Francisella infection><Francisella tularensis><Francisella tularensis infection><Funding><Genus Mycobacterium><Goals><Good Manufacturing Process><Good manufacturing practice><Government Agencies><Grant><Guanosine Cyclic Monophosphate><HAZMAT><Hansen's Disease><Hazardous Chemicals><Hazardous Materials><Hazardous Substances><Human Resources><IT Systems><Industry><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Information Systems><Information Technology><Information Technology Systems><Infrastructure><Institution><Investigators><Investments><Laboratories><Leadership><Leprosy><Life Sciences><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MERS corona virus><MERS coronavirus><MERS virus><MERS-CoV><MTB infection><Maintenance><Manpower><Melioidosis><Middle East Respiratory Syndrome Corona Virus><Middle East Respiratory Syndrome Coronavirus><Middle East Respiratory Syndrome Virus><Middle East Respiratory Syndrome-CoV><Middle East Respiratory coronavirus><Middle Eastern Respiratory Syndrome Corona virus><Middle Eastern Respiratory Syndrome Coronavirus><Middle Eastern Respiratory Syndrome Virus><Middle Eastern Respiratory Syndrome-CoV><Mission><Modernization><Monkey Pox><Monkeypox><Mycobacterium><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NIAID><National Institute of Allergy and Infectious Disease><Operations Research><P pseudomallei><P. pseudomallei><Parents><Pasteurella tularensis><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Plague><Process><Pseudomonas pseudomallei><Public Health><Research><Research Personnel><Research Resources><Research Support><Researchers><Resolution><Resource Allocation><Resource Development><Resources><Risk><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Science><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Sight><Site><Spinal Column><Spine><Structure><System><TB infection><Training><Translational Research><Translational Science><Tuberculosis><Tularemia><Universities><Update><Venezuelan Equine Encephalitis><Venezuelan Equine Encephalomyelitis><Venezuelan Equine Fever><Vertebral column><Veterinary Medicine><Vision><Work><Workforce Development><Wuhan coronavirus><Yersinia pestis disease><aged><backbone><bacteria pathogen><bacterial pathogen><biodefense><biologic><biosafety level 3 facility><biosecurity><cGMP><career aspiration><career interest><career pathway><career track><college><collegiate><coronavirus disease 2019 virus><coronavirus disease-19 virus><cost><design><designing><disseminated TB><disseminated tuberculosis><emerging pathogen><faculty research><hCoV19><haz mat><health economics><improved><infected with F tularensis><infected with F. tularensis><infected with Francisella tularensis><infection due to Mycobacterium tuberculosis><instrument><job environment><laboratory facility><manufacture><mpox><nCoV2><new pathogen><non-tuberculosis mycobacteria><non-tuberculosis mycobacterial><non-tuberculous mycobacteria><non-tuberculous mycobacterial><nontuberculosis mycobacterial><nontuberculous mycobacteria><nontuberculous mycobacterial><novel pathogen><operation><operations><pandemic><pandemic concern><pandemic disease><pandemic potential><pandemic risk><pandemic threat><parent><pathogen><pathogenic bacteria><personnel><pharmaceutical><professional atmosphere><programs><repair><repaired><resolutions><response><socio-economic><socio-economically><socioeconomically><socioeconomics><translation research><translational investigation><tuberculosis infection><tuberculous spondyloarthropathy><usability><viral pandemic><visiting scholar><visual function><work atmosphere><work environment><workplace climate><workplace environment>