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Principal Investigator: Anthony Griffiths
Organization: UNIVERSITY OF MISSOURI-COLUMBIA
Fiscal Year: 2024
Award: $2,375,210
Funding agency: National Institute of Allergy and Infectious Diseases
Overall Project Summary
Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University
of Missouri Regional Biocontainment Laboratory
The University of Missouri Regional Biocontainment Laboratory (RBL) was commissioned in 2009 as an $18M,
12,377 NSF BSL-3/ABSL-3 facility. During its thirteen years of operation, the RBL, since named the MU
Laboratory for Infectious Disease Research (LIDR) has been a centerpiece of the broader infectious disease
research community at the University of Missouri, receiving strong institutional commitment in the recruitment
and sustainment of world-class faculty for management of the RBL/LIDR and for conducting research on high
priority pathogens. The LIDR operates shared research resources, including state-of-the-art equipment and
professional services in microbiology, aerobiology, immunology, and animal model core facilities that serve the
needs of researchers on campus and in the broader regional and national communities. The faculty and
professional staff of the LIDR are part of the NIH/NIAID RBL-NBL network, with collaborative interactions that
facilitate sharing of best practices and knowledge, providing synergy in achieving our collective biodefense and
emerging infectious disease research agenda. During the COVID pandemic, the MU LIDR, along with its RBL
and NBL partners, led the response to the pandemic and are committed to strengthening pandemic
preparedness of the nation, by providing BSL-3/ABSL-3 training, professional staff, and research services that
allow for rapid responses in all areas, including development of animal models and the evaluation of numerous
treatments, disinfectants, and vaccine platforms to combat the pandemic. The long-term goal of the present
application is to sustain a leading effort for development of novel medical countermeasures for combating the
ever present and changing threats of emerging and re-emerging infectious diseases, while training an
outstanding cadre of next generation scientists and professionals in biocontainment. The goals of the proposed
cores in Facility Management, Maintenance and Operations, BSL3 Practices, and Biocontainment Research
Support Services are to educate and train the next generation of scientists and biocontainment professionals in
biodefense and emerging infectious diseases, and to facilitate and enhance the development of novel
approaches for prevention and treatment of infections caused by high consequence pathogens whose natural
or deliberate transmission pose a threat to public health and national security. Towards these goals, the proposed
Cores will work within the broader infectious disease community at MU and the NIH/NIAID RBL-NBL network for
enhancement of research productivity and discovery, and continued sharing of information and best practices in
order to meet the changing priorities and needs of NIH/NIAID for biodefense and emerging infectious diseases.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Acceleration><Address><Adoption><Animal Housing><Animal Model><Animal Models and Related Studies><Appointment><Approaches to prevention><Arboviral><Arboviruses><Area><Arthropod-Borne Viruses><Award><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 virus><COVID-19 years><COVID19 virus><CV-19><CoV-2><CoV2><Communicable Diseases><Communities><Core Facility><Coronavirus Infectious Disease 2019><Decontamination><Dedications><Development><Development and Research><Disease Outbreaks><Disinfectants><Emerging Communicable Diseases><Emerging Infectious Diseases><Equipment><Evaluation><Event><Evolution><Faculty><Funding><Generalized Growth><Goals><Grant><Grippe><Growth><Human><Human Resources><Image><Immunology><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Influenza><Infrastructure><Institution><Investigators><Investments><Knowledge><Laboratories><Leadership><Maintenance><Manpower><Microbiology><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Mission><Missouri><Modern Man><Modernization><NIAID><NIH><Names><National Institute of Allergy and Infectious Disease><National Institutes of Health><National Security><Outbreaks><Output><Phase><Preparation><Prevention approach><Productivity><Public Health><R & D><R&D><Regulation><Research><Research Personnel><Research Resources><Research Support><Researchers><Resource Development><Resources><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Scientist><Secure><Security><Senior Scientist><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><System><Technology><Tissue Growth><Training><Transmission><United States National Institutes of Health><Universities><Virus><Work><Workforce Development><Wuhan coronavirus><animal model development><biocontainment facility><biocontainment lab><biocontainment laboratory><biodefense><combat><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><coronavirus infectious disease-19><developmental><emergent outbreak><emerging outbreak><experience><future outbreak><hCoV19><imaging><improved><instrumentation><lab assignment><lab experiment><laboratory activity><laboratory assignment><laboratory exercise><laboratory experiment><medical countermeasure><member><microbial><model of animal><nCoV2><name><named><naming><new approaches><new outbreak><new technology><next generation><next outbreak><novel><novel approaches><novel outbreak><novel strategies><novel strategy><novel technologies><ontogeny><operation><operations><outbreak in the future><pandemic><pandemic concern><pandemic disease><pandemic disease preparedness><pandemic planning><pandemic potential><pandemic preparedness><pandemic readiness><pandemic risk><pandemic threat><pathogen><personnel><preparations><prevent><preventing><priority pathogen><programs><public health relevance><recruit><research and development><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><synergism><transmission process><vaccine platform><vector-borne><vectorborne>