NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sizun Jiang · BETH ISRAEL DEACONESS MEDICAL CENTER · 2022 · $372,900 — PROJECT SUMMARY/ABSTRACT Distinctive host-pathogen interactions and adaptations are the cornerstones of co-evolution between eukaryotes and their viral pathogens. Given the rapid replication and mutation rates of RNA viruses within their host, understanding these intra-host interactions in their nat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Matthew Walter Eskew · THERMOCAP LABORATORIES INC. · 2022 · $258,625 — Abstract An attractive feature of using in vitro expression systems to generate biological compounds is the capability to produce a wide variety of compounds (proteins, peptides, antibodies) on various scales, in a cheap and rapid manner. Current methods to analyze any of these produced compounds re…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sabita Roy · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 · $153,500 — Project Summary Infection with Covid-19 has reached pandemic status with more than 125 million confirmed cases and 2.75 million deaths making it one of the most deadliest pandemics in history. It is associated with severe acute respiratory syndrome symptoms with high fatality rates. SARS-CoV-2 infec…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
DUXIN SUN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $513,210 — Various nanoparticles (NPs) have been used for delivery of small antigens, which have limited viral mimic features and are more efficacious than soluble antigens in stimulating B-cell immunity. However, these traditional NPs lack characteristics of virus “spiky capsid protein peplomer”, e.g. spiky a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Goran Bajic · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $795,351 — Immunodominance, the observation that epitopes on an antigen are not “born equal”, poses a major challenge for next-generation vaccines against rapidly evolving pathogens. An underlying premise of this proposal is that in order to engage in rational immunogen design for next-generation vaccines, we …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
JOHN P MOORE · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $4,149,892 — Overall Abstract This HIVRAD Program Project renewal application is made in response to PAR-18-319. It contains two Research Projects, one Scientific Core and an Administrative Core, under the direction of Principal Investigator, John P. Moore, PhD (Weill Cornell Medical College; WCMC) and co-Princi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
RICK B MEEKER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $388,750 — HIV infection of the nervous system results in chronic infection, inflammation and cognitive decline in many patients with no effective treatments. Inflammation appears early in the disease process and causes progressive neural damage due, in part, to factors released by activated microglia and macr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
James J Kobie · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $841,228 — PROJECT SUMMARY SARS-CoV-2 has infected over 138 million people and resulted in over 2.8 million deaths so far, with the expectation the pandemic will continue for many more months, and the virus will persist endemically for years, exacerbated by emerging variants of concern (VoC). Although several …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
HENRIQUE Prado VON GERSDORFF · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $375,943 — PROJECT SUMMARY The major goal of this Administrative Supplement is to determine the changes in neuronal excitability and synaptic strength within the mammalian auditory brainstem during Alzheimer’s disease (AD) and during age related hearing loss (ARHL). We will use well established transgenic mous…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Timothy O'Connor · ROCKEFELLER UNIVERSITY · 2022 · $7,019,416 — Project Summary/Abstract Rockefeller University is a unique institution: with only 70 Heads of Laboratories, the faculty have received 3 Nobel prizes in Medicine in the last 10 years and 5 (plus 1 in chemistry) in the last 21 years, along with appointment of 18 faculty as HHMI investigators and 29 t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Jane R Taylor · YALE UNIVERSITY · 2022 · $330,750 — Drug-associated conditioned stimuli (CS), or cues, contribute to both the progression and persistence of addiction. We hypothesize, as have others, that blocking reconsolidation of cocaine-cue memories could prevent cue-induced relapse. Reconsolidation is a process whereby reactivation of a memory r…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
MANOJ K PATEL · UNIVERSITY OF VIRGINIA · 2022 · $399,015 — Epilepsy is a major economic and personal burden for the American public, affecting over 3 million Americans (1-2% of the population) with over 200,000 new cases diagnosed each year. There is no cure for epilepsy. Seizures can only be suppressed using antiepileptic drugs. Unfortunately, these drugs …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
WEI CHEN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $234,000 — Abstract The long-term goal of our research is to develop effective therapies against SARS-CoV-2-elicited disease Covid-19. SARS-CoV-2 spike (S) protein binds to its cognate receptor, angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine proteas…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Magnus Adrian Gero Hoffmann · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2022 · $421,000 — Project Summary/Abstract The COVID-19 pandemic represents the 3rd outbreak caused by zoonotic transmission of a beta-coronavirus (beta-CoV) in the last 20 years. Hence there is an urgent need for new vaccine strategies to control the ongoing pandemic and prevent future CoV outbreaks. mRNA vaccines h…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Peter Palese · ROCKEFELLER UNIVERSITY · 2022 · $130,823 — Abstract Given the uncontrolled spread of SARS-CoV-2 and the devastating impact on public health, therapeutic interventions are urgently needed for disease control. Indeed, several biotech and academic groups are currently focusing their efforts on the isolation and clinical development of monoclona…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Joana Almaca · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 · $383,750 — ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is still the most common cause of mortality in COVID-19 patien…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Steve J Smith · SOUTH DAKOTA SCHOOL OF MINES AND TECHN'Y · 2022 · $413,479 — Project Summary Tumor metastasis accounts for 90% of cancer-associated mortality. Epithelial-mesenchymal transition (EMT) of cancer cells provides the cancer cells with strong migratory-invasive abilities, and more recently, to mediate the development of chemoresistance, which is linked to cancer st…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sarah E. Millar · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $748,027 — Project Summary/Abstract The COVID-19 pandemic has produced a global health and economic crisis. While the pandemic is gradually being lessened by mass vaccinations, full control of this disaster is hampered by several ongoing problems including: (i) resistance or poor access to vaccination; (ii) em…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Mark L Baccei · UNIVERSITY OF CINCINNATI · 2022 · $461,894 — Project Summary/Abstract Long-term potentiation (LTP) of primary afferent synapses onto spinal projection neurons (PNs) has been linked to increased pain sensitivity. The timing rules controlling the generation of LTP in adult PNs can be persistently relaxed by neonatal tissue damage, which likely …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
TIMOTHY A HAYSTEAD · EYDIS BIO, INC. · 2022 · $284,707 — PROJECT SUMMARY/ABSTRACT The recent pandemic of novel coronavirus, COVID-19, has had a devastating effect on the health and well-being of individuals across the globe, including over 3.1 million confirmed infected so far, and a monumental impact on global healthcare systems and economies at large. I…