AC'ME, noun Ac'my [Gr.] The top or highest point. It is used to denote the maturity or perfection of an animal. Among physicians, the crisis of a disease, or its utmost violence. Old medical writers divided the progress of a disease into four periods, the arche, or beginning, the anabasis, or increase, the acme or utmost violence, and the paracme, or decline. But acme can hardly be considered as a legitimate English word.
Source: Webster's 1828 American Dictionary ↗ · public-domain · returned verbatim, no AI