From: F1000 Biology Update <[email protected]>

From: F1000 Biology Update <[email protected]> To: Jeff Epstein <[email protected]> Subject: The link between moral disgust and bad taste, a new development in monoclonal antibodies and much more! Date: Wed, 06 May 2009 11:03:25 +0000 View in your defult web browser. Search F1000 Biology 06-May-2009 gA'Submit Please note: The search function will not work for all email clients. Click here to search FI000 Biology. jFac ulty Faculty of 1000 Biology Faculty of 1000 Biology In this issue... -tJ -LJ Major Advances. Expert Opinions. F1000 Biolou Reports Editor's choice: Is there a link between moral disgust and bad taste? Take advantage of limited full access to some of FI000 Biology's most popular recent evaluations Broad impact: A new development in monoclonal antibodies Hidden Jewel: Fundamental role of nitrogen limitation in the evolution of plant genomes F1000 Twitter Link Recommend F1000 to your librarian! Faculty of 1000 Biology Leaflets F1000 Biology Reports See the latest issue of F1000 Biology Reports, which contains 8 new articles, including one entitled Applications of high- throughput sequencing to chromatin structure and function in mammals by Genomics & Genetics Faculty Member Ian Dunham.r1000 Reports Logo] If you would like to be alerted about the most recently published F1000 Reports each month, please email [email protected] and put "F1000 Biology Reports" in the subject heading. back to tan EFTA00774613 Editor's choice: Is there a link between moral disgust and bad taste? Many of us use the phrase "it leaves a bad taste in your mouth" to express moral disgust, but findings in this new paper suggest that this metaphor may be even more fitting than previously thought! The authors of this thought-provoking paper, evaluated by Kent Berridge of the Neuroscience Faculty, find that moral outrage and a bad taste appear to activate the same facial muscles and produce the same expressions. Dr Berridge writes "A morally disgusting outcome may taste bad almost literally, according to this intriguing study. When presented with an unfair deal, people make faint versions of the same facial expressions that they show to an unpleasantly bitter or sour taste: wrinkling the nose and raising the upper lip." Kent explains "The authors suggest that their results support the hypothesis that moral disgust arose in human evolution from basic chemosensory affective precursors." He also expands on this to say_ "A corollary of that hypothesis is that moral disgust may recruit some of the same affective neural circuitry which generates oral disgust to avoid bitter or other unpalatable food, and which may have evolved originally for avoidance of poisonous foods." Read the comments in full back to too Take advantage of limited full access to some of F1000 Biology's most popular recent evaluations This paper identifies the different experimental factors of sedimentation velocity analytical ultracentrifugation (SV-AUC) that affect the precision of the estimated amounts of oligomeric aggregates present in protein samples...MORE Selected by 'Peter Schuck (National Institutes of Health (NIH), United States of America) with Huaying Zhao Pe \I u“ Read FI000 Factor 6.0 Detection of protein aggregates by sedimentation velocity analytical ultracentrifugation (SV-AUC): Sources of variability and their relative importance. Arthur KK et al. J Pharm Sci 2009 Jan 7 Old guys smell better and get more sex: this provocative paper suggests that in the European corn borer Ostrinia nubilalis an age-related male pheromone drives female mating choice, shedding light on the mechanisms of sympatric speciation...MORE Selected by 'Steven Reppert (University of Massachusetts Medical School, United States of America) with Christine Merlin Concerted evolution of male and female display traits in the European corn borer, Ostrinia nubilalis. Lassance and Lofsedt, CBMC Biol 2009 Mar 3 7(I):10 Pro Iru In this exciting paper, the authors demonstrate that the prion PrPSc is transferred between cells in tunnelling nanotubes (TNTs). This symplastic route to infection is EFTA00774614 reminiscent of the invasion of plant tissues by plant viruses and may represent an evolutionarily conserved process...MORE Selected b And Maule (John Innes Centre, Norwich, United Kingdom) Prions hijack tunnelling nanotubes for intercellular spread. Gousset K et al. Nat Cell Biol 2009 Mar 11(3):328-36 This paper is the first report of dystrophin-restored expression in a dog model of Duchenne Muscular Dystrophy (DMD). This study constitutes a proof-of-principle that a morpholino-mediated exon-skipping strategy can be used to remove more than one exon and rescue dystrophin expression to a therapeutic level in a DMD dog...MORE Selected by I David Sassoon (University of Marie and Pierre Curie, France) with Keren Bismuth Exccptiiindl Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs. Yokota T et al. Ann Neurol 2009 Mar 13 II .taat Facto, 9.0 This is the first study that shows de novo mutations in a gene that lead to autosomal- dominant mental retardation in patients. It is a breakthrough in the field of mental retardation research as genes hitherto identified as causative are nearly exclusively located on the X-chromosome...MORE Selected by I R Frank Kooy (University of Antwerp, Belgium) Mutations in SYNGAP I in autosomal nonsyndromic mental retardation. I 6.0 I Hamdan FF et al. N Engl J Med 2009 Feb 5 360(6):599-605 F. Mu,( Read hack to ton Wit Broad Impact: A new development in monoclonal antibodies It has previously been suggested that antibody can only bind to one antigen. A recent study by scientists in San Franscisco has used the cancer drug Herceptin to create an antibody that binds to a second antigen. Peter Colman of the Structural Biology Faculty, with W Douglas Fairlie, explains "This paper describes a procedure by which a monoclonal antibody directed at human epidermal growth factor receptor 2 (HER2) has been modified so as to acquire high affinity to a second antigen, vascular endothelial growth factor (VEGF), whilst retaining HER2 binding." Dominique Eladari of the ay) siology Faculty, with Bharath Wootla, tells us "Structural studies presented a large degree of homology between the two antigen-binding sites on the bH1 antibody. The authors, furthermore, elegantly demonstrate the positive pharmacological effect of the bi-specific antibody in an in vivo model, using an affinity- improved variant of bH1 (bH1-44)." Chemical Biology Faculty Member Carlos F Barbas believes "Two-in-one antibodies of the type developed by Fuh et al. and other bi- and multifunctional approaches will be key both in treating disease and in creating an affordable class of drugs in the future." EFTA00774615 Kermit Carraway of the Cell Biology Faculty goes on to explain "These antibody variants should provide excellent reagents for therapies of cancers that require HER2 and angiogenesis for tumor progression." It is obvious that this article has important implications for the development of future treatments for diseases such as cancer. The structure of Faculty of 1000 Biology makes it possible to identify papers of broad interest, irrespective of the journal in which they are published. You can see the full comments of all the evaluating Faculty Members on this Exceptional Broad Impact paper by visiting the Faculty of 1000 Biology website. hack to tots :2 D:- Hidden Jewel: Fundamental role of nitrogen limitation in the evolution of plant genomes An article recently highlighted by Christian Meyer of the Plant Biology Faculty studied the influence of ecological limitations on the composition of eukaryotic genomes. Christian tells us "This interesting paper suggests that nitrogen limitation may have influenced the DNA and amino-acid compositions of plant genomes and proteomes. This hypothesis relies on the observation that the transcribed plant genomes are nitrogen-poor when compared to the whole genome composition, whereas animal genomes and transcriptomes have almost the same N content." He found "The observation that a domesticated plant like rice has a significantly higher N content in the transcribed genome than Arabidopsis is quite interesting since, according to the authors, this could reflect the fact that rice was not (or less) N-limited through the domestication process, which could have relieved its genome from selection pressure." [See full evaluation] The Hidden Jewels lists are one of the most popular features on the Faculty of 1000 Biology site as they bring to scientists' attention papers they otherwise might have missed (especially in fields adjacent to their own). These lists are compiled daily and include highly viewed papers evaluated within the previous month. hack to too RiTwitter Logo] F1000 Twitter Link! Follow the Faculty of 1000 on Twitter: http://twitter.corral000. Our feed is open to all and contains breaking news, updates and links to specific evaluations that catch our eye. EFTA00774616 hack to too Recommend F1000 to your librarian! Over 90% of the world's top institutions currently subscribe to F1000 Biology and many more are trialling. Why not visit the site to see if your own institute has access. If your institution does not have access, then please recommend the service to your library or institution so that they can arrange a free 30-day trial. You can use our online form to send your recommendation. If you prefer, there is a printable form (PDF). Alternatively, you may qualify for free access via HINARI or Faculty Member sponsorships: see http://www.f1000biology.com/about/hinari. hack to too Faculty of 1000 Biology leaflets To make it even easier to let your friends and colleagues know about Faculty of 1000 Biology, we have developed two Faculty of 1000 leaflets, which give more information on using the site and making the most of the various features available. Please click on the image of the leaflets below to download them in PDF format. Why not share a few copies with your colleagues and lab members? F1000 Leaflet F1000 Leaflet Please note that there is also a site demonstrafon available at www.f1000biology.com: either click on the walkthrough button, or go straight there by clicking here. hack to too You have received this message because you asked to receive updates from Faculty of 1000 Biology. Your registered email address is: jeeprojectgyahoo.com EFTA00774617 Please click here if you do not wish to receive any flintier messages from this thou Unsubscri !ion For further information or enquiries please contact Customer Services at: FI000 Biology. Biology Repons Ltd Science Navigation Group. Middkscx House, 34-42 Ckveland Street. London. WIT 4LB. United Kingdom EFTA00774618