Document text
Introduction to the HPV Vaccines Work Group
Oliver Brooks, MD
Chair, HPV Vaccine Work Group
Advisory Committee on Immunization Practices
June 28, 2024
National Center for Immunization & Respiratory Diseases
2006 2011 2016 2019 Recommendation for Females
Routine : 11 or 12 years ,
can be started at age 9
Catch -up: through 26 years
3-dose scheduleEvolution of HPV vaccination recommendations –
United States
2Recommendation for Males
Routine : 11 or 12 years ,
can be started at age 9
Catch -up: through 21 years
3-dose schedule2-dose schedule
if first dose
age <15 yearsCatch -up: through 26
Shared clinical decision -
making : some adults
27 through 45 years
2006 2011 2016 2019 Recommendation for Females
Routine : 11 or 12 years ,
can be started at age 9
Catch -up: through 26 years
3-dose scheduleEvolution of HPV vaccination recommendations –
United States
3Recommendation for Males
Routine : 11 or 12 years ,
can be started at age 9
Catch -up: through 21 years
3-dose schedule2-dose schedule
if first dose
age <15 yearsCatch -up: through 26
Shared clinical decision -
making : some adults
27 through 45 years
Quadrivalent Vaccine
Bivalent VaccineVaccines
available
9-valent Vaccine
•Routine vaccination
-Age 11 or 12 years
-Can be started at age 9 years
•Catch -up vaccination
-Through age 26 years
•Shared clinical decision -making
-Age 27–45 yearsCurrent HPV vaccination recommendations,
United States
Recommendations of the Centers for Disease Control and Prevention and the Advisory Committee on Immunization Practices
https://www.cdc.gov/vaccines/hcp/acip -recs/vacc -specific/hpv.html Number of doses
2 doses (0, 6 -12 months)
if starting series before 15th birthday
3 doses (0,1-2, 6 months)
if starting series on or after 15th birthday or if
immunocompromising condition
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•Number of doses in the recommended HPV vaccination series
•Wording of the age for routine vaccination
•Guidance regarding persons in the “shared clinical decision -making” age
range (27 –45 years)Topics to be considered by HPV Vaccines Work Group
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•Number of doses in the recommended HPV vaccination series
-Accumulating evidence on efficacy of HPV vaccination with fewer doses
-In 2022, the World Health Organization recommended a two -dose schedule for
persons aged 9 years or older and, a s an off -label option, a single -dose schedule
can be used for those aged 9 –20 yearsTopics to be considered by HPV Vaccines Work Group
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•Wording of the age for routine HPV vaccination
-Some stakeholders interested in starting vaccination at age 9 years
-Current ACIP recommendations are consistent with vaccination at age 9 years
-Modification of wording could allow more flexibility Topics to be considered by HPV Vaccines Work Group
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•Guidance regarding persons in the “shared clinical decision -making” age
range (27 –45 years)
-Shared clinical decision -making recommendation made in 2019
-Interest in providing more guidance for subgroups in this age rangeTopics to be considered by HPV Vaccines Work Group
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•July 2024 – first meeting of Work Group
•October 2024 – presentation of general issues to full ACIP
-Number of doses in the HPV vaccination schedule
-Routine age recommendation wordingACIP HPV Vaccines Work Group initial timeline
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ACIP HPV Vaccines Work Group
Chair
•Oliver Brooks
CDC Co -Leads
•Lauri Markowitz
•Carla DeSistoWork Group Members
•Pending
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