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CHIKUNGUNYA VACCINES
ACIP Meeting
April 16, 2025
Edwin Asturias, MD
Chair, ACIP Chikungunya Vaccines Work Group
•Chikungunya Vaccines Work Group formed in May 2022
-Topics under discussion include use of chikungunya vaccines in U.S. persons at
risk of chikungunya, including those who travel abroad, laboratory workers, and
residents of U.S. territories and states at risk of transmission
•Two chikungunya vaccines
-Live attenuated vaccine licensed in November 2023 (manufactured by Valneva)
-Virus -like particle vaccine licensed in February 2025 (manufactured by Bavarian
Nordic)
-Both vaccines licensed based on immunogenicity correlates and safety, pending
clinical efficacy and expanded safety post -licensure studiesBackground
•October 2022– October 2023
-Background on chikungunya disease and its epidemiology
-Immunogenicity and safety of live attenuated chikungunya vaccine (CHIK -LA)
•February 2024
-ACIP approval of recommendations for use of CHIK -LA among U.S. travelers and
laboratory workers
•June 2024
-Epidemiology of chikungunya in U.S. territories and states
-Cost -effectiveness of use of CHIK -LA in U.S. territories
•October 2024
-Immunogenicity and safety of virus -like particle chikungunya vaccine (CHIK -VLP)Recap of previous Work Group ACIP presentations
1. Evidence to Recommendations for use of CHIK -VLP among adolescent
and adult travelers ( Vote 1 )
2. Evidence to Recommendations for use of CHIK -VLP among laboratory
workers ( Vote 2 )
3. Surveillance for adverse events following use of CHIK -LA and proposed
guidance for use and revised recommendations (Vote 3 )
4. Clinical guidance for use of CHIK -VLP among pregnant and breastfeeding
womenOverview of today’s session
Chikungunya Vaccines Work Group members
ACIP ACIP Liaisons Invited Consultants ( cont )
Edwin Asturias, Univ Colorado Elizabeth Barnett, ISTM Steven Schofield, CATMAT
Lin Chen, Mount Auburn Hosp James Campbell, AAP David Shlim, Jackson Hole Travel & Trop Med
Mary Pat Friedlander, AAFP Nestor Sosa, Uni New Mexico Hospital
CDC Lead Saroj Rai, AIM Sanet Torres, San Jorge Children & Women's Hospital
Susan Hills, DVBD Kirsten Vannice, Bill & Melinda Gates Foundation
Invited Consultants Mary Wilson, Univ California San Francisco
Ex Officio Alan Barrett, Univ Texas Galveston Joshua Wong, US Coast Guard Puerto Rico
Robin Levis, FDA Beth Bell, Univ Washington
Sixun Yang, FDA Alan Lam, DoD
Lesley Dupuy (NIH) Margaret Ryan, DoD
Chikungunya Vaccines Work Group CDC participants
DVBD DGMH ACIP Secretariat (NCIRD)
Sarah Guagliardo Kevin O’Laughlin Jessica MacNeil
Ann Powers Leslie Lee
Erin Staples DHQP
Parker Acevedo Michael McNeil
Laura Adams
GID
NCEZID Pierre Muhoza
Chris Braden