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CHIKUNGUNYA VACCINES
Wilbur Chen, MD, MS
Chair, ACIP Chikungunya Vaccines Work GroupACIP Meeting
February 28, 2024
Background
Chikungunya vaccine (manufactured by Valneva) was licensed in the
United States in November 2023
No other chikungunya vaccine licensed globally
No existing ACIP chikungunya vaccine recommendations
Chikungunya Vaccines Work Group is developing policy options for ACIP’s consideration for use of chikungunya vaccine among U.S. persons at risk of
chikungunya, including travelers, laboratory workers, and residents of U.S.
territories and states with risk of transmission
Recap of previous Work Group presentations to ACIP (1)
October 2022
–Overview of chikungunya virus disease and vaccines
–Immunogenicity and safety of Valneva’s chikungunya vaccine
February 2023
–Global epidemiology of chikungunya
–Chikungunya among U.S. travelers
–Persistent arthralgia following chikungunya
June 2023
–Value of a vaccine to U.S. travelers
–Chikungunya virus infection among laboratory workers
–Observations on a large chikungunya outbreak in Paraguay
Recap of previous Work Group presentations to ACIP (2)
October 2023
–Evidence to Recommendations ( EtR) and proposed policy options for
chikungunya vaccine use among U.S. adult travelers
–EtR and proposed policy options for chikungunya vaccine use among
U.S. laboratory workers
Overview of today’s session
Update on chikungunya vaccine licensure
Review of proposed policy options for chikungunya vaccine use among
U.S. adult travelers *
Review of proposed policy options for chikungunya vaccine use among
U.S. laboratory workers *
Proposed clinical guidance for vaccine use among pregnant and
breastfeeding persons
*For vote today
ACIP Ex Officio ( cont ) Invited Consultants ( cont )
Wilbur Chen, Univ Maryland Lesley Dupuy, NIH Beth Bell, Univ Washington
Matthew Daley, Kaiser Permanente Carina Blackmore, Florida Dept Health
ACIP Liaisons Alan Lam, DoD
CDC Leads Elizabeth Barnett, ISTM Margaret Ryan, DoD
Susan Hills, DVBD (Lead) James Campbell, AAP Steven Schofield, CATMAT
Nicole Lindsey, DVBD (Deputy Lead) Mary Pat Friedlander, AAFP David Shlim, Jackson Hole Travel & Trop Med
Saroj Rai, AIM Nestor Sosa, Uni New Mexico Hospital
Ex Officio Sanet Torres, San Jorge Children & Women's Hospital
Robin Levis, FDA Invited Consultants Kirsten Vannice, Bill & Melinda Gates Foundation
Sixun Yang, FDA Alan Barrett, Univ Texas Galveston Mary Wilson, Univ California San FranciscoChikungunya Vaccines Work Group members
DVBD DGMQ ISD
Erin Staples Kevin McLaughlin Elisabeth Velazque z
Sarah Guagliardo
Ann Powers DHQP GRADE/ETR consultants
Laura Adams Michael McNeil Doug Campos -Outcalt
Joshua Wong Rebecca Morgan
GID
NCEZID Rebecca Casey ACIP Secretariat
Rita Helfand Jessica MacNeil, NCIRD
Leslie Lee, NCIRDChikungunya Vaccines Work Group CDC participants