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CHIKUNGUNYA VACCINES
ACIP Meeting
October 23, 2024
Edwin Asturias, MD
Chair, ACIP Chikungunya Vaccines Work Group
•Chikungunya Vaccines Work Group formed in May 2022
•Chikungunya vaccines
-Live attenuated vaccine licensed in November 2023 (manufactured by Valneva)
-Virus -like particle vaccine submitted to FDA for licensure (manufactured by
Bavarian Nordic)
•Some recommendations developed, and others under development, for
use of chikungunya vaccines among U.S. persons at risk of chikungunya
including travelers, laboratory workers, and residents of U.S. territories and
states with risk of transmissionBackground
•October 2022– October 2023
-Chikungunya virus disease and its sequelae
-Chikungunya epidemiology globally and among U.S. travelers and laboratory
workers
-Live attenuated chikungunya vaccine including immunogenicity, safety, and other topics
•February 2024
-ACIP approved recommendations for use of live attenuated chikungunya vaccine among U.S. travelers and laboratory workers
•June 2024
-Epidemiology of chikungunya in U.S. territories and states
-Cost -effectiveness of use of live attenuated chikungunya vaccine among adults
living in U.S. territories Recap of previous Work Group ACIP presentations
1. Update on chikungunya and chikungunya vaccines
2. Virus -like particle chikungunya vaccine
3. Work Group interpretation of chikungunya virus -like particle vaccine
dataOverview of today’s session
Chikungunya Vaccines Work Group members
ACIP ACIP Liaisons Invited Consultants ( cont )
Edwin Asturias, Univ Colorado Elizabeth Barnett, ISTM Margaret Ryan, DoD
Lin Chen, Mount Auburn Hosp James Campbell, AAP Steven Schofield, CATMAT
Mary Pat Friedlander, AAFP David Shlim, Jackson Hole Travel & Trop Med
CDC Lead Saroj Rai, AIM Nestor Sosa, Uni New Mexico Hospital
Susan Hills, DVBD Sanet Torres, San Jorge Children & Women's Hospital
Invited Consultants Kirsten Vannice, Bill & Melinda Gates Foundation
Ex Officio Alan Barrett, Univ Texas Galveston Mary Wilson, Univ California San Francisco
Robin Levis, FDA Beth Bell, Univ Washington
Sixun Yang, FDA Carina Blackmore, Florida Dept Health
Lesley Dupuy (NIH) Alan Lam, DoD
Chikungunya Vaccines Work Group CDC participants
DVBD DGMH GRADE/ETR consultants
Sarah Guagliardo Kevin O’Laughlin Doug Campos -Outcalt
Ann Powers Rebecca Morgan
Erin Staples DHQP
Parker Acevedo Michael McNeil ACIP Secretariat
Laura Adams Jessica MacNeil, NCIRD
Joshua Wong GID Leslie Lee, NCIRD
Pierre Muhoza
NCEZID
Rita Helfand