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Principal Investigator: Mehdi Hedjazi Moghari
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2024
Award: $210,927
Funding agency: National Heart Lung and Blood Institute
Abstract
Congenital heart disease (CHD) affects approximately 1.2% of children and is the leading cause of birth defect-
related deaths. Single ventricle heart disease (SVHD) is a severe form of CHD, with high morbidity and
mortality. These patients require multiple palliative surgeries, culminating with a total cavopulmonary
anastomosis. Despite considerable improvement in the survival of patients with SVHD, there is increasing
morbidity and mortality over time. It remains unclear why some SVHD patients fail their surgical repairs while
others remain relatively well. Clinicians often rely on 2-dimensional (2D) images acquired from
echocardiograms, catheterizations, or cardiovascular magnetic resonance (CMR) exams to assess SVHD
patients and qualitatively choose the optimal surgical repair. The 2D images, however, lead to a suboptimal
understanding of the complex 3D spatial relationships and hemodynamics, and limit efficient decision making.
To address this deficiency, a free-breathing sequence is developed to acquire 3D cine CMR images of the
heart and great vessels in 10 minutes. The 3D block of data will be used to generate a patient-specific pulsatile
heart model. This heart model will be used to simulate the patient cardiovascular system with a lumped-
parameter model. The lumped-parameter model will be used to simulate different surgical repairs and
quantitatively choose the most optimal repair for each patient. We expect that this platform rationalizes
surgeons' decisions for the best surgical approach and improves the survival rate of patients with SVHD.
Terms: <0-11 years old><0-4 weeks old><2-dimensional><3-D><3-D modeling><3-Dimensional><3D><3D modeling><Acceleration><Address><Affect><Algorithms><Anastomosis><Anastomosis - action><Anatomic Sites><Anatomic structures><Anatomy><Anesthesia><Anesthesia procedures><Applications Grants><Birth Defects><Blood><Blood Pressure><Blood Reticuloendothelial System><Blood flow><Breathing><Cardiac><Cardiac Malformation><Cardiac Surgery><Cardiac Surgery procedures><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Catheterization><Cessation of life><Child><Child Youth><Children (0-21)><Circulation><Compensation><Complex><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><ConvNet><Data><Data Set><Death><Decision Making><Echocardiogram><Echocardiography><Elasticity><Elements><Friction><Grant Proposals><Heart><Heart Malformation><Heart Surgical Procedures><Heart Vascular><Image><Lead><Life><Liquid substance><Lung><Lung Respiratory System><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Modeling><Morbidity><Morbidity - disease rate><Motion><Myocardium><NMR Imaging><NMR Tomography><Newborn Infant><Newborns><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Outcome><Palliative Surgery><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Pb element><Phase><Position><Positioning Attribute><Property><Radial><Radius><Rationalization><Research><Respiratory Aspiration><Respiratory Inspiration><Single ventricle congenital heart disease><Surface><Surgeon><Surgical><Surgical Interventions><Surgical Models><Surgical Procedure><Surgical Simulation><Survival Rate><System><Time><Transthoracic Echocardiography><United States><Venous system><Zeugmatography><abnormal heart development><auto-segmentation><automated segmentation><automatic segmentation><autosegmentation><blood flow measurement><cardiac function><cardiac imaging><cardiac motion><cardiac muscle><cardiac scanning><circulatory system><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><convolutional network><convolutional neural nets><convolutional neural network><design><designing><expiration><fluid><function of the heart><heart function><heart imaging><heart motion><heart muscle><heart scanning><heart sonography><heart surgery><heavy metal Pb><heavy metal lead><hemodynamics><image registration><image-based method><imaging><imaging method><imaging modality><improved><inspiration><kids><liquid><math methodology><math methods><mathematical approach><mathematical methodology><mathematical methods><mathematics approach><mathematics methodology><mathematics methods><mortality><newborn child><newborn children><pulmonary><reconstruction><repair><repaired><respiratory><segmentation algorithm><simulation><single ventricle congenital heart defect><single ventricle defect><single ventricle disease><single ventricle heart defect><single ventricle heart disease><spatial relationship><surgery><three dimensional><three-dimensional modeling><two-dimensional><vector><virtual reality surgery><virtual surgery><viscoelasticity><youngster>