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Principal Investigator: GERALD MCGWIN
Organization: UNIVERSITY OF MINNESOTA
Fiscal Year: 2024
Award: $1,144,582
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases
Project Summary
Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms,
including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e.,
bed-wetting), difficulty urinating, dribbling after urination, and bladder or urethral pain before, during, or after
urination. More than 200 million people worldwide and over 15% of women aged 40 years or older suffer from
urinary incontinence. In fact, women are 2-3 times more likely to experience urinary incontinence and 4 times
more likely to experience a urinary tract infection in comparison to men. For decades LUTS research has
focused on underlying pathology, disease mechanisms, and treatment efficacy. The NIDDK took a bold step by
introducing the concept of prevention as an important priority for women's urologic research.
Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms
Research Consortium (PLUS-RC) is creating new conceptual models and paradigms, developing innovative
measures, establishing evidence, and leading and seeding research on bladder health and LUTS prevention.
As the Scientific and Data Coordinating Center (SDCC) for this unique consortium since its inception, we are
excited to further develop the evidence base to empower women and their communities to advocate for an
environment that supports healthy bladders.
During this next grant period, we plan to (1) provide leadership, management, and biostatistical support in the
design and implementation of a nationally and regionally representative prospective longitudinal cohort study to
assess the distribution of bladder health and evaluate potential risk and protective factors that influence
bladder health status; (2) provide leadership, management, and biostatistical support in the analysis of existing
studies (quantitative and qualitative) that will lead to the collaborative development of conceptual models that
guide analyses within the observational study above, and new studies that support future primary or secondary
prevention initiatives; (3) provide leadership in the principles and process devoted to item development,
instrument development, and psychometric evaluation and scoring; (4) facilitate a network of community
stakeholders to assist and collaborate in the process of data collection development, execution, and
dissemination; (5) foster transdisciplinary team science across all consortium activities and centers; and (6)
provide administrative leadership and logistical support and coordination of meetings of the Steering
Committee, all subcommittees, the Executive Committee, the External Expert Panel, and the pilot and
feasibility studies program, for the efficient and ethical execution of consortium objectives.
Terms: <12-20 years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Address><Adolescence><Adopted><Advocate><Affect><Aged 65 and Over><Athletic><Attitude><Award><Behavior><Belief><Biology><Biometrics><Biometry><Biostatistical Methods><Biostatistics><Bladder><Bladder Urinary System><Classification><Clinical><Collaborations><Communities><Community Developments><Community Networks><Data><Data Analyses><Data Analysis><Data Collection><Data Coordinating Center><Data Coordination Center><Development><Device or Instrument Development><Disease><Disorder><Enuresis><Environment><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Ethics><Evaluation><Feasibility Studies><Fostering><Future><Goals><Grant><Health><Health Status><Housing><Incontinence when straining><Intervention><Intervention Strategies><Investigators><Knowledge><Lead><Leadership><Learning><Level of Health><Life Cycle><Life Cycle Stages><Long-term cohort study><Longitudinal cohort study><Longterm cohort study><Measurement><Measures><Modeling><Monitor><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Observation research><Observation study><Observational Study><Observational research><Pain><Painful><Pathology><Pb element><Perception><Persons><Phase><Pilot Projects><Position><Positioning Attribute><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Prevention><Process><Psychometrics><QOL><Quality of life><Recreation><Research><Research Personnel><Researchers><Review Literature><Risk Factors><Role><Science><Secondary Prevention><Site><Social Interaction><Societies><Source><Stress Incontinence><Stress Urinary Incontinence><Symptoms><Systematics><Techniques><Testing><Treatment Efficacy><Update><Urethra><Urgency to pass urine><Urgent desire to urinate><Urinary Incontinence><Urinary tract infection><Urinary tract infectious disease><Urination><Woman><Work><above age 65><adolescence (12-20)><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged><aged 65 and greater><aged 65+><aged ≥65><bedwetting><biopsychosocial><biopsychosocial factor><biopsychosocial variable><clinical care><community engaged approach><community engaged approaches><community engaged strategies><community engaged strategy><community partnered approach><community partnered strategy><data interpretation><data management><data management and coordinating center><data management center><design><designing><developmental><device development><empowerment><epidemiologic investigation><epidemiology study><ethical><evidence base><experience><girls><health determinants><health level><heavy metal Pb><heavy metal lead><human old age (65+)><innovate><innovation><innovative><instrument><instrument development><intervention efficacy><interventional strategy><life course><life span><lifespan><lower urinary tract symptoms><malleable risk><meeting><meetings><member><men><micturition><micturition urgency><modifiable risk><novel><old age><over 65 years><pilot study><population based><prevent><preventing><programs><prospective><protective factors><research study><social role><therapeutic efficacy><therapy efficacy><urethral><urinary bladder><urinary infection><urinary urgency><urination urgency><urologic><urological><web site><website><≥65 years>