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Principal Investigator: Edward W Boyer
Organization: OHIO STATE UNIVERSITY
Fiscal Year: 2024
Award: $191,325
Funding agency: National Institute on Drug Abuse
Abstract
Renewal of my Midcareer Investigator Award in Patient-Oriented Research (K24) will allow me to continue my strong efforts
directed toward successful original investigations and mentoring to generate research capacity in mobile technologies to
improve health (mHealth). The impact of the initial K24 on my mentees has been striking. Since award of the initial K24,
nearly two dozen of my mentees, 70% of whom are women or minorities, have been PI on NIH funded studies (under K, R,
or Loan Repayment Program mechanisms). The impact the K24 on my own research has been substantial. Since 2014, I
have been Principal Investigator (PI) on six federally funded awards: 1) one newly funded 4-year R01 from NIDA; 2) one R56
from NIDA; 3) one two-year R01 from NIDA; 4) one 4-year R01 from NIDA; 5) my K24 from NIDA; and 6) one newly funded
4-year DARPA research award. In addition, I received a William J Fulbright Foreign Scholarship to Malaysia. As my K24
evolved, so has my research focus. My overall research objective is to devote sufficient time to investigate use of next
generation (“NextGen”) technologies, invisible biosensing, and machine learning in substance abuse and HIV research. My
first research project, Virya, uses “digital phenotyping” with invisible biosensing and machine learning, to identify acute pain
exacerbations in HIV+ individuals on opioids, a population at risk for problematic opioid use. The second reseach project
uses mobile technologies to diagnose Covid-19 infection in HIV+ persons who inhale cannabis, itself a high-impact topic.
Finally, the R01-funded MyTPill project compares the NextGen technology of unobtrusive ingestible biosensors that provide
vivid, indisputable measures of medication ingestion. NextGen research discoveries become commercial products, but this
process of introducing new discoveries into the healthcare economy remains deeply unfamiliar—yet increasingly important—
to academic clinician-scientists. The objective of my Career Development Activities, therefore, involves learning how to
navigate regulatory processes, FDA approvals, valuations, venture capital, contracts and intellectual property rights. Because
of the growing importance of commercialization of research findings to the health and sustainability of academic careers, my
overall mentoring objective of this K24 is to develop researchers who not only have the skills to conduct rigorous NextGen
mHealth studies, but also to extend the mass of NIH-funded mHealth research into the healthcare economy. My mentoring
approach incorporates several components that contributed to the success of my initial K24: dedicated funding for mentee’s
early investigations; outstanding institutional support; several sources of referral of high-quality mentees; and renowned co-
mentors who will help me establish a pipeline of mentees that have risen to that “cutting edge” where successful academic
careers begin. This proposed K24 renewal, with its focus on NextGen technologies, invisible biosensing, and machine
learning, is highly relevant to NIH’s mission because the lessons learned from this substance abuse and HIV research are
directly applicable to the care of patients with common, intractable, and expensive conditions.
Terms: <21+ years old><AI system><AIDS Virus><Accelerometer><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute Pain><Address><Adherence><Adopted><Adult><Adult Human><Affect><Affective><Anti-Retroviral Agents><Area><Artificial Intelligence><Award><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biosensing Technics><Biosensing Techniques><Biosensor><Brain><Brain Nervous System><COVID diagnosis><COVID-19><COVID-19 diagnosis><COVID-19 infection><COVID-19 virus infection><COVID19 diagnosis><COVID19 infection><CV-19><Cannabis><Capital><Caring><Cell Phone><Cellular Phone><Cellular Telephone><Cognitive Discrimination><Collection><Communicable Diseases><Computer Reasoning><Conditioning Therapy><Contracting Opportunities><Contracts><Coronavirus Infectious Disease 2019><Data><Data Collection><Dedications><Development><Devices><Diagnosis><Discipline><Discrimination><Drug abuse><Drug usage><Drugs><Educational process of instructing><Electrical Engineering><Electronics><Encephalon><Exhalation><Exhaling><Federation of Malaya><Funding><General Population><General Public><Goals><Groups at risk><HIV><Health><Health Care Technology><Health Technology><Health behavior><Healthcare><Healthcare Technology><Human><Human Immunodeficiency Viruses><IRB><IRBs><Imagery><Individual><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Ingestion><Inhalation><Inhaling><Institution><Institutional Review Boards><Intellectual Property><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Investigation><Investigators><K24 Award><K24 Mechanism><K24 Program><LAV-HTLV-III><Learning><Life><Lymphadenopathy-Associated Virus><Machine Intelligence><Machine Learning><Malay Federation><Malaya><Malaysia><Maps><Measures><Medical><Medication><Mental Depression><Mentors><Methods><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Minority><Mission><Mobile Phones><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><Music><NIDA><NIH><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Nerve Impulse Transmission><Nerve Transmission><Neuronal Transmission><Nociception><Opiates><Opioid><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Pattern><Penetrance><People at risk><Persons><Persons at risk><Pharmaceutical Preparations><Phone><Play><Population><Populations at Risk><Principal Investigator><Process><Property Rights><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Respiratory Expiration><Rewards><Risk Behaviors><Risky Behavior><Role><SARS-CoV-2 diagnosis><SARS-CoV-2 infection><SARS-CoV2 infection><Scholarship><Scientist><Self Management><Severe acute respiratory syndrome coronavirus 2 infection><Source><Substance Use Disorder><Substance abuse problem><Teaching><Techniques><Technology><Telephone><Temperature><Testing><Text Messaging><Time><United States National Institutes of Health><Viral Diseases><Virus Diseases><Virus-HIV><Woman><Wrist><abuse of drugs><abuse of substances><abuses drugs><accelerometry><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><activity monitor><activity tracker><adulthood><anti-retroviral><antiretroviral therapy><antiretroviral treatment><at risk behavior><axon signaling><axon-glial signaling><axonal signaling><behavior intervention><behavioral intervention><biological sensor><biosensing><body sensor><body worn sensor><care for patients><care of patients><career><career development><caring for patients><co-morbid><co-morbidity><cohort><commercialization><comorbidity><computer scientist><coronavirus diagnosis><coronavirus disease 2019><coronavirus disease 2019 diagnosis><coronavirus disease 2019 infection><coronavirus disease diagnosis><coronavirus disease-19><coronavirus infectious disease-19><depression><design><designing><detector><develop therapy><developmental><diagnosed with COVID><diagnosed with COVID-19><diagnosed with COVID19><diagnosed with SARS-CoV-2><diagnosed with coronavirus><diagnosed with coronavirus 2019><diagnosed with coronavirus disease><diagnosed with coronavirus disease 2019><digital divide><digital phenotyping><digital technology><disparity in care><disparity in healthcare><drug adherence><drug compliance><drug use><drug/agent><electronic><electronic device><experience><glia signaling><glial signaling><health care><health care access><health care availability><health care disparity><health care economics><health care inequality><health care inequity><health care service access><health care service availability><health data><health related behavior><healthcare access><healthcare accessibility><healthcare availability><healthcare disparity><healthcare economics><healthcare inequality><healthcare inequity><healthcare service access><healthcare service availability><iPhone><improved><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><ingest><innovate><innovation><innovative><interest><intervention development><interventional strategy><irritation><m-Health><mHealth><machine based learning><magnetic field><medication adherence><medication compliance><mobile computing><mobile health><mobile platform><mobile technology><nasal swab><nerve signaling><neural signaling><neuronal signaling><neurotransmission><next generation><nociceptive><novel><opiate consumption><opiate drug use><opiate intake><opiate tolerance><opiate use><opioid consumption><opioid drug use><opioid habituation><opioid intake><opioid tolerance><opioid use><pathway><personal protection equipment><personal protective equipment><pill><prevent substance abuse><programs><response><severe acute respiratory syndrome coronavirus 2 diagnosis><short message service><skills><smart phone><smartphone><social role><social stigma><socio-economic><socio-economically><socioeconomically><socioeconomics><stigma><substance abuse><substance abuse control><substance abuse prevention><substance abuse therapy><substance abuse treatment><substance use and disorder><success><texting><theories><therapy adherence><therapy compliance><therapy development><tolerance to opiates><treatment development><viral infection><virus infection><virus-induced disease><wearable biosensor><wearable sensor><wearable sensor technology>