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Principal Investigator: Olu Olofinboba
Organization: MOAI TECHNOLOGIES, LLC
Fiscal Year: 2024
Award: $808,635
Funding agency: National Institute on Aging
Project Summary/Abstract
Alzheimer’s disease (AD) affects more than six million Americans currently and is projected to affect 14 million
at a cost of $1.2 trillion in 2050. Despite its tremendous impacts and the limited influence of pharmacological
therapies, attention has been brought to non-pharmacological interventions as promising therapeutic strategies
for the prevention of cognitive decline. Aerobic exercise and cognitive training, particularly when in combination
represent important behavioral interventions for cognition in persons at risk for AD. Both preventative medicine
therapies are cost-effective strategies and aim to preserve the mental abilities, daily living performance, and
cognitive well-being of individuals in the early stages of the disease. The proposed project will build on findings
from the Phase II pilot where the feasibility and efficacy of Virtual Reality Cognitive Training (VRCT) combined
with concurrent aerobic cycling (Exergame) was demonstrated in a clinical trial. This clinical trial was
conducted utilizing a supervised intervention model, which is important for demonstrating preliminary feasibility
and efficacy, but has limitations for addressing real-world feasibility and sustainability. Currently, the top two
reported barriers for participation in community or facility-based, preventive medicine therapies such as
exercise and cognitive training include burdens of travel or time commitment. Recently, advancements in
technology have allowed for home-based (asynchronous) telerehabilitation interventions such as exercise
training to be utilized as a supplement or replacement to conventional, synchronous rehabilitation programs.
Although telerehabilitation is a growing form of therapy, it has yet to be studied in persons at risk for AD or with
Exergame therapy. In order for Exergames to be a sustainable preventive medicine approach to AD, its
feasibility and efficacy in a home-based (asynchronous) setting is needed. In order to expand our reach and
marketability of the Exergame and combat these participation barriers, the sustainability and efficacy of
Exergames in a home-based environment must be addressed. In support of expanding the reach and
marketability of the Exergame, the purpose of this project is to: 1) develop a fully-featured version of the VRCT
aspect of the Exergame that can be installed and updated remotely in order to support home-based use and,
2) assess the feasibility, efficacy, and sustainability of the Exergame in a home-based, asynchronous
telerehabilitation setting via a clinical trial. Once the fully-featured Exergame with remote installation and
updating capacity has been completed, the clinical trial, using a 2:2 factorial design will randomize 104
community-dwelling older adults at risk of AD to one of four arms for 3 months: home-based (asynchronous)
Exergames, supervised Exergame, home-based asynchronous aerobic exercise, or supervised aerobic
exercise. This project is innovative as 1) it addresses barriers for the real world use of the Exergame, which will
increase the reach and marketability of the product, and 2) the clinical trial uses gold standard laboratory, real
world (“field”), and novel blood biomarker efficacy and sustainability assessments of the Exergames.
Terms: <AD dementia><Address><Adherence><Aerobic><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Amentia><American><Attention><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Blood><Blood Reticuloendothelial System><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Clinical Trials><Clinical Trials Design><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Combined Modality Therapy><Communities><Conditioning Therapy><Dementia><Disease><Disorder><Disturbance in cognition><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drugs><Environment><Epidemic><Exercise><Groups at risk><Habilitation><Home><Impaired cognition><Individual><Intervention><Intervention Strategies><Laboratories><Liquid substance><Measures><Medical Rehabilitation><Medication><Minnesota><Modeling><Multimodal Therapy><Multimodal Treatment><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Outcome><Participant><People at risk><Performance><Personal Satisfaction><Persons><Persons at risk><Pharmaceutical Preparations><Phase><Populations at Risk><Preventative strategy><Prevention strategy><Preventive Medicine><Preventive strategy><Primary Senile Degenerative Dementia><Psyche structure><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Rehabilitation><Rehabilitation therapy><Reporting><Research Grants><Research Project Grants><Research Projects><Risk><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Science><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><Technology><Testing><Therapeutic><Time><Travel><Universities><Update><Work><alzheimer risk><arm><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><cognitive dysfunction><cognitive loss><cognitive task><cognitive training><combat><combination therapy><combined modality treatment><combined treatment><commercialization><community setting><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><cost effective therapy><cost effective treatment><design><designing><determine efficacy><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><exercise training><exergame><experience><flexibility><flexible><fluid><homes><improved><innovate><innovation><innovative><intervention delivery><intervention design><interventional strategy><liquid><mental><multi-modal therapy><multi-modal treatment><neuroprotection><neuroprotective><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><older adult><older adulthood><pharmacologic><preference><preservation><prevent><preventative medicine><preventing><primary degenerative dementia><primary outcome><processing speed><programs><randomisation><randomization><randomly assigned><rehab therapy><rehabilitative><rehabilitative therapy><satisfaction><secondary outcome><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telerehab><telerehabilitation><therapy design><treatment design><usability><user-friendly><virtual environment><virtual reality><well-being><wellbeing>