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Principal Investigator: Jeremy Dahl
Organization: SONOVANCE, INC.
Fiscal Year: 2024
Award: $294,641
Funding agency: National Institute of Biomedical Imaging and Bioengineering
Abstract
As currently practiced, ultrasound imaging, recognized universally as being of great health care importance,
requires the operator to have considerable training and anatomic and medical image understanding. Access to
low-cost imaging services for millions of patients in-home, rural areas and clinics is restricted due to the lack of
experienced sonographers and clinicians who can effectively acquire high quality scans. Sonovance, a
Maryland small business, is addressing this need by developing a low-cost system for operators with no prior
training to acquire diagnostic ultrasound images with standard and portable systems and probes, including
mobile devices. The approach uses a simple geometric model to represent the imaging target region, a
position sensor to report the location and orientation of the probe, and a calibration procedure by which to co-
register the target region to the patient. The user interface guides the operator’s positioning of the probe to
acquire 2D images that intersect the target region, providing continuous visual feedback as to which regions
require additional scanning without requiring the user to view the images themselves. The system reconstructs
these images into a rectangular 3D image volume covering the target region. Sonovance has completed a
prototype system using a standard Interson probe and an attached electromagnetic sensor to capture position
information which has been shown to successfully capture and reconstruct 3D images at prescribed locations
on an abdominal phantom.
Two key aims are to be addressed to accomplish the overall goal of arriving at a low-cost and clinically useful
prototype from the current one validated on a phantom. Aim 1 is to optimize and validate the company’s
patented system for guiding unskilled operators to obtain acceptable diagnostic ultrasound images of the
kidneys in human patients. Aim 2 is to further reduce the system cost by employing low-cost inertial position
sensors and implementing an image reconstruction method based on a statistical image model with position
correction to address the reduced accuracy of the positional data. The two goals are independent of each other
and can be developed in parallel. Following successful proof of concept in this study, Phase II research will
focus on clinical trials to evaluate and optimize the accuracy and usability of the system by novice users for
kidney and urinary tract ultrasound imaging. The overall goal of the program is to develop the software into a
product deployable worldwide and build out a “full body” of clinical scanning protocols that can be delivered
with the technology. Health systems will be able to deploy novice user scanning with existing AI solutions to
assist in diagnostic interpretation based on the patient population. The clinical imaging protocols can be
developed by Sonovance, or others via APIs, and will include abdominal, cardiac, Doppler, and OB-GYN. This
research aligns with NIBIB’s mission to support ultrasound image acquisition and display as well as innovative
signal processing and supports the mission of the Point of Care Technologies Network (POCTRN).
Terms: <3-D><3-D Images><3-D image><3-Dimensional><3D><3D image><3D images><Abdomen><Acceleration><Access to Care><Accident and Emergency department><Acute><Address><Anatomic Sites><Anatomic structures><Anatomy><Appearance><Bladder><Bladder Urinary System><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Calculi><Calibration><Cardiac><Caring><Cell Communication and Signaling><Cell Signaling><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinic><Clinical><Clinical Services><Clinical Trials><Clinics and Hospitals><Clinics or Hospitals><Computer Models><Computer software><Computerized Models><Cyst><Data><Development><Devices><Diagnosis><Diagnostic><Diagnostic Imaging><Discipline of Nursing><ED visit><ER visit><Echography><Echotomography><Electromagnetics><Emergency Department><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room><Emergency room visit><Environment><Feedback><Future><Goals><Grant><Health Services Accessibility><Health system><Healthcare><Home><Home Care><Hospitals><Human><Human Volunteers><Image><Individual><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Kidney><Kidney Calculi><Kidney Stones><Kidney Urinary System><Knowledge><Learning><Legal patent><Life><Location><Maryland><Measurement><Medical Imaging><Medical Ultrasound><Medicine><Methods><Mission><Modeling><Modern Man><NIBIB><National Institute of Biomedical Imaging and Bioengineering><Nature><Nurses><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Obstruction><Operating Rooms><Organ><Outcome><Parameter Estimation><Patents><Patients><Phase><Physicians><Pilot Projects><Point of Care Technology><Position><Positioning Attribute><Procedures><Process><Protocol><Protocols documentation><Radiography><Renal Calculi><Renal Stone><Reporting><Research><Research Resources><Resolution><Resources><Roentgenography><Rural><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Scanning><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Signal Transduction><Signal Transduction Systems><Signaling><Software><System><Technology><Testing><Three-Dimensional Image><Training><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Urinary tract><access to health services><access to services><access to treatment><accessibility to health services><anatomic imaging><anatomical imaging><availability of services><biological signal transduction><care access><chronic kidney disease><clinical imaging><computational modeling><computational models><computer based models><computerized modeling><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><cost effective><data acquisition><data acquisitions><develop software><developing computer software><developmental><diagnostic ultrasound><experience><global health><handheld mobile device><health care><health service access><health services availability><homes><image construction><image generation><image processing><image 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location><under served region><underserved area><underserved geographic area><underserved location><underserved region><urgent care><urinary bladder><usability><visual feedback>