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Principal Investigator: Tim Alan Ahles
Organization: CITY COLLEGE OF NEW YORK
Fiscal Year: 2024
Award: $1,334,500
Funding agency: National Cancer Institute
The CCNY-MSKCC Partnership has successfully created a mutually beneficial, cross-institutional collaboration
that has emphasized research across the translational T0-T4 continuum, the creation of an education pipeline
for attracting underrepresented students from diverse backgrounds to careers in cancer research, and the
establishment of community networks and resources for conducting linguistically and culturally responsive
community engaged outreach and research among diverse, at-risk populations. Over the next five years, the
Partnership focus will be Translational Cancer Research for Health Equity. Consistent with this emphasis,
our research projects will focus on: 1) understanding the biological and social determinants of health factors that
increase risk for adverse events associated with immune checkpoint inhibitors and evaluating a social drivers of
health intervention designed to reduce side effect severity and improve treatment adherence; 2) an examination
of small molecule regulation of cancer-driving transcription factors using an integrated strategy of structural,
chemical, and cellular approaches that could lead to targeted treatments relevant to cancers common in
underserved populations; 3) the impact of AI integrated, UN-style medical interpreting engineering solutions on
access to cancer care; 4) identification of germline and/or ancestry/race-specific environmental/social factors
influencing the tumor genome of lung cancers and the joint effect of African ancestry and smoking on somatic
mutations. The Specific Aims are to (1) continue to develop outstanding cancer research programs, through
the lens of health equity, on social determinants of health, biomedical engineering, computer science, medical
imaging, cancer cell biology, precision medicine, and immunology along the Translational Research Continuum;
(2) collaborate with diverse communities to conduct and facilitate trailblazing cancer disparities research,
outreach, education, risk reduction, and navigation activities to define and address cancer disparities, with the
goal of improving cancer care in the large, medically underserved local and national communities; (3) continue
to develop and expand educational opportunities in a robust translational cancer research environment to attract,
nurture and retain students and Early-Stage Investigators interested in cancer research, particularly
underrepresented students and low-income students; and (4) expand and integrate the personnel development,
resources, and environment needed for scientific collaboration across institutions, to increase capacity for
linguistically and culturally responsive research and clinical care, and to influence institutional policies to support
and sustain translational research in cancer disparities and health equity.
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Terms: <Address><Affect><African ancestry><African descent><Area><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Biological><Biomedical Engineering><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Cancer Research Programs><Cancer Research Project><Cancers><Caring><Cellular biology><Checkpoint inhibitor><Chemicals><Cities><Clinical Trials><Collaborations><Communities><Community Networks><Community Outreach><Coronavirus Infectious Disease 2019><Development><Distance Learning><Education><Education and Outreach><Educational Activities><Educational aspects><Engineering><Environment><Evaluation><Faculty Recruitment><Funding><General Transcription Factor Gene><General Transcription Factors><Germ Lines><Goals><Groups at risk><Health><Health Disparities Research><Health Policy><Health disparities related research><Health equity research><Healthcare><Human Resources><Immune checkpoint inhibitor><Immunology><Institution><Institutional Policy><Instruction and Outreach><International><Investigators><Joints><Language><Linguistic><Linguistics><Low income><MSKCC><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Manpower><Medical><Medical Imaging><Memorial Sloan-Kettering Cancer Center><Mentorship><Modeling><New York><Outcome><People at risk><Persons at risk><Policies><Populations at Risk><Productivity><Pulmonary Cancer><Pulmonary malignant Neoplasm><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Regulation><Research><Research Activity><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research in health equity><Researchers><Resource Sharing><Resources><Risk Factors><Risk Reduction><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Scientist><Screening for cancer><Secure><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severities><Smoking><Somatic Mutation><Students><Testing><Training><Training and Outreach><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Translational Research><Translational Science><Translations><Tutoring and Outreach><Underrepresented Students><Underserved Population><Vaccination><adverse event risk><anti-cancer research><bio-engineered><bio-engineers><bioengineering><biologic><biological engineering><cancer care><cancer cell><cancer cell genome><cancer disparity><cancer genome><cancer health disparity><cancer research><cancer-related health disparity><career><cell biology><clinical care><college><collegiate><community engaged participatory research><community engaged research><community engagement><community partnered research><community-engaged study><community-partnered study><computer science><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><developmental><disparity in cancer><driving><early cancer detection><economic determinant><education research><engagement with communities><health care><health care policy><health disparities science><health equity><health equity-focused research><healthcare policy><immune check point inhibitor><improved><individualized prevention><innovate><innovation><innovative><interest><intervention design><lung cancer><malignancy><marginalized group><marginalized individual><marginalized people><marginalized population><medically under served><medically underserved><member><neoplasm/cancer><outreach><personalization of treatment><personalized medicine><personalized prevention><personalized therapy><personalized treatment><personnel><precision medicine><precision prevention><precision-based medicine><programs><racial><racial background><racial origin><recruit teachers><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><remote learning><research into practice><research on health equity><research related to health equity><research to attain health equity><research to practice><response><risk-reducing><screening><screening cancer patients><screenings><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><side effect><small molecule><social><social factors><social health determinants><socio-economic><socio-economically><socioeconomically><socioeconomics><somatic variant><student retention><teacher recruitment><therapy design><transcription factor><translation><translation research><translational cancer research><translational investigation><treatment adherence><treatment compliance><treatment design><tumor genome><under served community><under served group><under served individual><under served people><under served population><underserved community><underserved group><underserved individual><underserved people><work group><working group>