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Principal Investigator: Janet Ellen Dancey
Organization: QUEEN'S UNIVERSITY AT KINGSTON
Fiscal Year: 2024
Award: $2,333,866
Funding agency: National Cancer Institute
Summary
The transformational advances in cancer biology and technologies to characterize cancers at a molecular
level, combined with the rapid expansion of novel drugs and cellular therapies, mandates a fundamental re-
evaluation of clinical trial design and delivery to ensure maximal patient and societal benefits. The
Canadian Cancer Trials Group (CCTG) has strong partnerships with US investigators and groups within
the NCTN, which emphasize international collaboration to conduct definitive practice-changing trials, trials
in rare cancers settings, and trials testing precision-medicine strategies. As the Canadian Collaborating
Clinical Trials Network (CCCTN) of the NCTN, CCTG expands NCTN's scientific expertise by: 1)
Involving the best and brightest within its network in NCTN leadership roles; 2) Increasing clinical trial
capacity through its national network, which includes all centres in Canada; and, 3) Facilitates access to
Canadian patients, which is particularly important for trials testing interventions in rare populations. CCTG
contributes to scientific concept development, accrual, biospecimen collection, and network leadership, and
has expertise in instrumental components of trial conduct (including information technology and
regulations). CCTG develops and participates in NCTN adult cancer trial portfolios in breast, lung,
urological, and gastrointestinal malignancies, in uncommon/rare settings of unmet need such as
hematological, skin, brain and head and neck cancers, and includes adolescents and young adults on AYA
trials. In addition, CCTG capitalizes on opportunities to extend its scope of trial activity to include surgical
and lifestyle interventions and imaging and digital health endpoints. Research incorporates translational
science and other correlative endpoints to enrich information derived from NCTN trials and methods and
technology development to improve clinical trial designs, endpoints, and execution. Finally, CCTG
contributes trial datasets from NCTN trials as part of its data sharing policy. As the CCCTN, CCTG,
Canada's largest and most experienced clinical trials unit, creates and delivers innovative strategies that
arise from the NCTN accelerating the translation of scientific advances into improvements in cancer
treatments improving the lives of children, adolescents, and adults diagnosed with cancer.
Terms: <0-11 years old><21+ years old><Acceleration><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Advisory Committees><Big Data><BigData><Brain><Brain Nervous System><Breast><CTCAE><CTEP><Canada><Cancer Biology><Cancer Patient><Cancer Therapy Evaluation Program><Cancer Treatment><Cancers><Cell Therapy><Child><Child Youth><Children (0-21)><Clinical><Clinical Evaluation><Clinical Testing><Clinical Trials><Clinical Trials Design><Clinical Trials Network><Clinical Trials Unit><Collaborations><Collection><Common Terminology Criteria for Adverse Events><Common Toxicity Criteria><Conduct Clinical Trials><Data><Data Set><Development><Diagnosis><Drug Therapy><Education><Educational aspects><Encephalon><Ensure><Ethics><Evaluation><GI cancers><GI malignancies><GI tract cancers><Gastrointestinal Cancer><Gastrointestinal Tract Cancer><Goals><Head and Neck Cancer><Head and Neck Carcinoma><Health><Hematology><Image><Immunooncology><Information Technology><Infrastructure><International><Intervention><Intervention Strategies><Investigators><Lead><Leadership><Lung><Lung Respiratory System><Malignant Gastrointestinal Neoplasm><Malignant Head and Neck Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of gastrointestinal tract><Methodology><Molecular><Monitor><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multisite clinical trial><National Clinical Trials Network><Operative Procedures><Operative Surgical Procedures><Organization Charts><Outcome><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Pb element><Pharmacotherapy><Pilot Projects><Policies><Population><Precision Medicine Initiative><Process><Public Health><Regulation><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Science><Scientific Advances and Accomplishments><Site><Skin><Structure><Surgical><Surgical Interventions><Surgical Procedure><Task Forces><Technology><Testing><Training><Translating><Translational Research><Translational Science><Translations><adulthood><advisory team><anti-cancer therapy><cancer therapy><cancer-directed therapy><cancers that are rare><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><clinical test><cost><data sharing><developmental><digital health><drug treatment><ethical><examination questions><experience><gastrointestinal malignancies><head/neck cancer><health economics><heavy metal Pb><heavy metal lead><imaging><immune-oncology><immuno oncology><immunology oncology><improved><improved outcome><innovate><innovation><innovative><insight><interventional strategy><juvenile><juvenile human><kids><life style intervention><lifestyle intervention><malignancy><malignant head and neck tumor><meeting><meetings><method development><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncoimmunology><operation><operations><organizational structure><pilot study><precision medicine><precision-based medicine><programs><prospective><pulmonary><rare cancer><rare malignancy><rare tumor><research clinical testing><scientific accomplishments><scientific advances><social role><statistics><surgery><tech development><technology development><tool><translation><translation research><translational investigation><urologic><urological><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><youngster>