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Principal Investigator: J CHRISTOPHER STATES
Organization: UNIVERSITY OF LOUISVILLE
Fiscal Year: 2024
Award: $21,882
Funding agency: National Institute of Environmental Health Sciences
The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings
together a multidisciplinary group of investigators working together to develop a framework to understand the
complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage,
genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build
transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and
its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the
counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural
exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g.
cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the
nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in
the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet,
alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and
gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research
interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health
Science Facility Core promotes translation of basic science including assistance with both adult and pediatric
clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS
investigators and community groups with special focus on rural health care providers and youth groups. The
Pilot Project Program provides resources supporting new environmental health investigators, collaborations
between CIEHS members and established investigators bringing new skill sets to environmental health
problems, new avenues of environmental health research by CIEHS members, and community-engaged and
community-led research in collaboration with CIEHS members. A Career Development Program provides
mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two
facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The
CIEHS provides leadership in environmental health research, promotes investigation of the interactions of
chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next
generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger
ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville
Regional Community in collaboration with community partners.
Terms: <21+ years old><Adult><Adult Human><Agriculture><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Area><Basic Research><Basic Science><Biologic Models><Biological Models><Biometrics><Biometry><Biostatistics><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Causality><Chemicals><Childhood><Chloroethylene><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Trials><Clinical Trials Unit><Collaborations><Communication><Communities><Complex><Core Facility><County><Development><Diabetes Mellitus><Diet><Disease><Disease Outcome><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Education><Educational aspects><Environment><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Risk Factor><Environmental Toxin><EtOH drinking><EtOH use><Etiology><Exposure to><Funding><Gender><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genotype><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Grant><Health><Health Care Providers><Health Personnel><Health Sciences><Healthcare Providers><Healthcare worker><Heart Vascular><Human><Individual><Industrialization><Informatics><Inherited Predisposition><Inherited Susceptibility><Interdisciplinary Research><Interdisciplinary Study><Interest Group><Intervention><Intervention Strategies><Investigation><Investigators><Kentucky><Knowledge><Laboratories><Leadership><Life><Life Style><Lifestyle><Malignant Neoplasms><Malignant Tumor><Measurement><Mental disorders><Mental health disorders><Mentors><Mentorship><Metals><Model System><Modern Man><Modification><Multidisciplinary Collaboration><Multidisciplinary Research><Obesity><Organ><PCBs><Pathogenesis><Persons><Pilot Projects><Play><Pollution><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Position><Positioning Attribute><Predisposition><Preventative strategy><Prevention strategy><Preventive strategy><Program Development><Psychiatric Disease><Psychiatric Disorder><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Rural><Strategic vision><Susceptibility><Toxic Environmental Agents><Toxic Environmental Substances><Toxicant exposure><Toxicology><Training><Translating><Translations><United States><Universities><Vinyl Chloride><Youth><Youth 10-21><addiction><addictive disorder><adiposity><adulthood><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><amateur science><amateur scientists><built environment><career development><causation><chloro-ethene><chronic disorder><circulatory system><citizen science><citizen scientists><civic science><collaboration with communities><community based design><community based participatory research><community based research><community collaboration><community engagement><community led research><community participatory research><community partnered participatory research><community partners><community-based collaboration><community-based partners><corpulence><crowd science><crowd-sourced science><design><designing><developmental><diabetes><diets><disease causation><engagement with communities><environmental risk><environmental toxicant><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><exposure to tobacco><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><geographic site><health care personnel><health care worker><health provider><health science research><health workforce><healthcare personnel><improved><interventional strategy><life-style factor><lifestyle factors><malignancy><man><medical personnel><member><mental illness><metropolitan><multidisciplinary><neoplasm/cancer><next generation><participatory action research><pediatric><pilot study><pollutant><polychlorobiphenyl><programs><psychiatric illness><psychological disorder><recruit><response><rural environment><rural health care><rural healthcare><scientific citizenship><skills><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><stressor><tobacco exposure><tobacco products><toxic exposure><toxicant interaction><translation><treatment provider><urban environment><urban setting>