Document text
Principal Investigator: Deborah J Lenschow
Organization: WASHINGTON UNIVERSITY
Fiscal Year: 2024
Award: $777,498
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
OVERALL ABSTRACT
The WU-RDRRC seeks to advance the health of patients with rheumatic diseases by supporting enabling
technology and promoting the members’ basic, clinical, and translational research interests that are organized
around three major themes: 1) elucidating basic mechanisms of inflammation and autoimmunity; 2)
accelerating clinical/translational research to inform precision medicine; and 3) advancing genome engineering
and regenerative medicine to develop new treatment approaches for rheumatic diseases.
We posit that translational research endeavors in rheumatic diseases require a team approach cultivated in
a vibrant environment and supported by cross-disciplinary groups of experts and cutting-edge technologies.
Over the past four years, this operational philosophy and the infrastructure supported by the WU-RDRRC
perfectly positioned our investigators to increase the efficiency and impact of their research, allowed them to
quickly address emergent issues that arose during the COVID-19 pandemic, and helped a number of young
investigators obtain extramural funding and successfully transition to research independence. The WU-
RDRRC propose to continue promoting rheumatic disease research by: 1) providing the infrastructure,
education, and training needed to assist investigators with the experimental and scientific design of their
projects; 2) organizing and supporting Core laboratories that will adopt and apply innovative technologies and
expertise that would otherwise be unavailable to investigators in a cost-effective manner; 3) promoting interest
in rheumatic diseases research by engaging multidisciplinary teams and bringing together diverse disciplines
and clinical divisions to address roadblocks in translational science; 4) fostering the next generation of junior
investigators who are interested in the study of rheumatic disease-related areas.
To accomplish our goals we propose four cores: 1) a Biobank and Phenotyping Core to collect high-quality
biospecimens for downstream molecular analysis; 2) a Genome Engineering Core to generate bioengineered
cell-based therapies, knockin/knockout mice for testing in preclinical disease models; 3) a Cellular Imaging
Core that offers novel microscopy technologies for building models of health and disease; and 4) an
Administrative Core that promotes collaborative and synergistic interactions among rheumatic disease
researchers and the mentoring of junior and new investigators interested in rheumatic disease research.
In addition, we will address members’ evolving needs by expanding access to novel technologies such as
spatial transcriptomics, and the changing societal landscape by incorporating social determinants of health into
clinical data collection, and enhancing diversity of trainees entering the physician-scientist pathway.
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