Document text
Principal Investigator: Alessandro Sette
Organization: LA JOLLA INSTITUTE FOR IMMUNOLOGY
Fiscal Year: 2024
Award: $212,201
Funding agency: National Institute of Allergy and Infectious Diseases
CORE B, CLINICAL CORE SUMMARY
The success of the entire program is contingent upon successful accrual of human samples. The purpose of
Core B (Clinical Core) is to provide a centralized resource for the accrual of human lymph node (LN), head and
neck, nasopharyngeal swab (NP), peripheral blood mononuclear cells (PBMC), and sera and/or plasma samples.
This Core will also ensure the quality and uniformity of handling samples received. In addition to recruitment
goals, the goal of this Core is to design, establish, and maintain IRB approval while overseeing the quality control
of coded clinical information and donor samples. These functions are crucial to provide a strong foundation for
the studies described in the three proposed projects. The Core will be based at LJI at the John and Susan Major
Center for Clinical Investigation, the CCHI’s home institution. The Clinical Core will work closely with subcontracts
(Liverpool, U.K. and UCSD) to enable the acquisition of additional samples for Projects 1 and 3.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV vaccine><21+ years old><Adenoidal structure><Adenoids><Adherence><Adult><Adult Human><Antigens><Axillary Lymph Node><Axillary Node><Axillary lymph node group><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Benign><Biopsy><Blood Plasma><Blood donor><Body Tissues><CAIV-T><COVID-19><COVID-19 infection><COVID-19 vaccine><COVID-19 virus><COVID-19 virus infection><COVID19 infection><COVID19 virus><CV-19><Cell Body><Cells><Clinical><Clinical Immunology><Clinical Research><Clinical Study><CoV-2><CoV2><Code><Coding System><Collaborations><Collection><Coronavirus Infectious Disease 2019><Disease><Disorder><Enrollment><Ensure><Epithelium><FNA><Fine Needle Aspirate><Fine needle aspiration biopsy><Fine-Needle Aspiration><FluMist><Foundations><Germinal Center><Goals><Head and Neck><Head and Neck Lymph Node><Head and neck structure><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Home><Human><IRB><IRBs><Immune memory><Immune response><Immunization><Immunize><Immunologic Memory><Immunological Memory><Immunological response><Immunology><Individual><Inducer Cells><Inducer T-Lymphocytes><Influenza Vaccines><Institution><Institutional Review Boards><Intramuscular><Longitudinal Studies><Lymph Node Reticuloendothelial System><Lymph Node of Head, Face and Neck><Lymph node proper><Lymphatic nodes><Maintenance><Malignant><Malignant - descriptor><Memory B Cell><Memory B-Lymphocyte><Modern Man><Operative Procedures><Operative Surgical Procedures><PBMC><Participant><Patients><Peripheral Blood Mononuclear Cell><Pharyngeal Tonsil><Plasma><Plasma Serum><Population><Preparation><Property><Protocol><Protocols documentation><Quality Control><RNA vaccine><RNA-based vaccine><Research Institute><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 infection><SARS-CoV-2 vaccine><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 vaccine><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 vaccine><Severe acute respiratory syndrome related corona virus 2><Source><Structure of germinal center of lymph node><Surgical><Surgical Interventions><Surgical Procedure><T memory cell><T-Cells><T-Lymphocyte><Time><Tissue Sample><Tissues><Translational Research><Translational Science><Universities><Upper respiratory tract><Vaccinated><Vaccination><Vaccines><Whole Blood><Work><Wuhan coronavirus><adulthood><anamnestic reaction><booster dose><booster shot><booster vaccine><clinical center><clinical investigation><cohort><coronavirus disease 2019><coronavirus disease 2019 infection><coronavirus disease 2019 vaccine><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 vaccine><coronavirus disease-19 virus><coronavirus infectious disease-19><design><designing><enroll><experiment><experimental research><experimental study><experiments><flu vaccine><flu virus vaccine><hCoV19><homes><host response><immune system response><immunogen><immunoresponse><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><influenza virus vaccine><long-term study><longitudinal outcome studies><longterm study><lymph gland><lymph nodes><lymphnodes><mRNA vaccine><mRNA-based vaccine><memory T lymphocyte><minimally invasive><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><nCoV2><nasopharyngeal swab><pathogen><preparations><programs><recruit><resident memory T cell><respiratory pathogen><response><secondary immune response><success><surgery><thymus derived lymphocyte><tissue resident memory T cell><translation research><translational investigation><upper airway tract><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine against flu><vaccine against influenza><vaccine boost><vaccine candidates against SARS-CoV-2><vaccine for novel coronavirus><vaccines preventing COVID><vaccines to prevent COVID>