Targeting Endosomal GPCR (eGPCR) Signaling Platforms for the Treatment of Chronic Pain

NIH Pandemic-Era Grants

Pandemic Era Grants

2024

↗ Live URL (may be dead)

Document text

Principal Investigator: Edward  Wu
Organization: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
Fiscal Year: 2024
Award: $1,874,696
Funding agency: National Center for Advancing Translational Sciences

The small interfering RNA (siRNA) is carefully encapsulated within polymeric nanoparticles, which have been demonstrated to successfully deliver the therapeutic agent to endosomes specifically in spinal cord dorsal horn neurons following intrathecal administration. Extensive proof-of-concept efficacy studies of this innovative polymeric nanoparticle formulation have shown that it provides significantly prolonged efficacy when compared to traditional lipid nanoparticle formulations (LNP). Presently, pilot-scale production of the nanoparticle drug product is actively underway, with comprehensive formulation characterization being conducted to support the ongoing efforts in preclinical development and to ensure the robustness and scalability of this novel therapeutic approach.

Terms: <Acceleration><Address><Affect><Behavior><Brain><Brain Nervous System><CNS Nervous System><Central Nervous System><Clinical Trials><Discipline><Dorsal Horn Cells><Dorsal Horn Neurons><Dorsal Horn of the Spinal Cord><Encapsulated><Encephalon><Endocytosis><Endosomes><Ensure><Food and Drug Administration><Formulation><G Protein-Coupled Receptor Signaling><GPCR Signaling><HEAL Initiative><Helping End Addiction Long-term><Helping End Addiction Longterm><Helping to End Addiction Long-term><Helping to End Addiction Longterm><High Throughput Assay><Human Biology><Infrastructure><Investigational New Drug Application><Mediator><Medulla Spinalis><NCATS><NIH><National Center for Advancing Translational Sciences><National Institutes of Health><Nerve Transmitter Substances><Neural Transmission><Neuraxis><Neurotransmitters><Pain><Pain Control><Pain Therapy><Pain management><Painful><Peripheral Nervous System><Play><Post-operative Pain><Posterior Horn Cells><Posterior Horn Neurons><Postoperative Pain><Process><Production><RNA targeting drug><RNA targeting therapeutics><RNA-targeting therapy><Receptosomes><Rodent><Rodentia><Rodents Mammals><Role><Science><Short interfering RNA><Small Interfering RNA><Spinal Cord><Spinal cord posterior horn><Synaptic Transmission><Testing><Therapeutic><Therapeutic Agents><Transmission><USFDA><United States Food and Drug Administration><United States National Institutes of Health><Work><antagonism><antagonist><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><drug repositioning><drug repurposing><efficacy study><first in man><first-in-human><high throughput screening><human model><inflammatory pain><innovate><innovation><innovative><knock-down><knockdown><lipid based nanoparticle><lipid nanoparticle><model of human><nano particle><nano polymer><nano-sized particle><nanoparticle><nanoparticle drug><nanopolymer><nanosized particle><neuropathic pain><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><opiate crisis><opiate use disorder><opioid crisis><opioid epidemic><opioid use disorder><pain after surgery><pain treatment><painful neuropathy><post-surgical pain><postsurgical pain><pre-clinical development><pre-clinical study><preclinical development><preclinical study><repurposing agent><repurposing medication><siRNA><siRNA therapy><siRNA-based therapeutic><siRNA-based therapy><social role><therapeutic agent development><therapeutic candidate><therapeutic development><therapeutic siRNA><therapeutic small interfering RNA><transmission process><treat chronic pain>