Document text
Principal Investigator: Julie May Croff
Organization: OSU CENTER FOR HEALTH SCIENCES
Fiscal Year: 2024
Award: $1,844,721
Funding agency: National Institute of General Medical Sciences
ABSTRACT
The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing
an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at
Oklahoma State University (OSU). Two decades of epidemiological data document that Adverse Childhood
Experiences (ACEs) are prevalent and cumulative, have enduring negative consequences for physical and
mental health, and cost north America more than $758B in preventable health care. In order to reduce the
costly effects of ACEs, research is increasingly focused on identifying mechanisms and processes by which
ACEs impact developing nervous, endocrine, metabolic, and immune systems, and intergenerational
biobehavioral pathways of transmission, as well as potential pathways for prevention, recovery, and healing.
This research is interdisciplinary by design and reliant on a team science approach, requiring researchers with
the capacity to collaborate in transdisciplinary teams.14, 15 The goals of CIRCA during Phase 1 were to
increase institutional research infrastructure to support a cadre of collaborative investigators achieve
independent funding on adversity and resilience. OSU invested approximately $10M in facilities, equipment,
faculty, and staff, significantly increasing capacity for biobehavioral research on adversity. The 5 research
project leaders (RPLs) and 8 pilot project leaders in Phase 1 obtained $16.3M in external grant support, with
an $8.2M increase in NIH funding. Phase 2 will expand and strengthen this interdisciplinary and collaborative
center of biomedical research excellence by a) building institutional and center infrastructure using a team
science approach; b) supporting and mentoring early-career investigators in their programs of research; c)
developing vibrant, sustainable research cores; and d) generating innovative transdisciplinary approaches
focused on the synergistic impacts of genetic, biological, environmental, and developmental influences on risk
and resilience over the life course. Phase 2 projects will investigate neurobiological mechanisms and
developmental processes linking childhood adversity with subsequent health problems using a theoretical
framework developed by CIRCA investigators during Phase 1. The proposed research projects and planned
pilot projects will be supported by an Administrative Core, a Recruitment, Engagement, Collection, and
Assessment (RECA) Core and a Biological Systems Core. Each project will contribute to a common set of
biological and behavioral measures, establishing a sustainable CIRCA Databank for current and future
research. This proposed Phase 2 CoBRE is highly innovative in that it addresses the need to prepare a new
generation of scientists with the capacity to identify and target the biobehavioral and developmental processes
linking early life adversity with negative health outcomes. It is significant in that it will create a sustainable
center providing opportunities for collaboration and a biobehavioral databank for current and future
investigators in a region characterized by high rates of ACEs and historical trauma.
Terms: <Address><Adolescent><Adolescent Youth><Aeroseb-HC><Affect><Anterior><Behavior><Behavioral><Biological><Blood monocyte><Brain region><COBRE><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><Cell Body><Cells><Center of Biomedical Research Excellence><Centers of Research Excellence><Cetacort><Collaborations><Collection><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data Banks><Databanks><Daughter><Dendritic Cells><Dermacort><Development><Developmental Process><Eldecort><Endocrine><Epidemiological data><Epidemiology data><Equipment><Faculty><Functional MRI><Functional Magnetic Resonance Imaging><Funding><Future><Gene Expression><Generalized Growth><Generations><Genes><Genetic><Glucocorticoids><Goals><Grant><Growth><Health><Health Promotion><Health Sciences><Healthcare><History><Human Development><Hydrocortisone><Hydrocortone><Hytone><Immune><Immune system><Immunes><Infrastructure><Institution><Investigators><Investments><Knowledge><Life Cycle><Life Cycle Stages><Link><Marrow monocyte><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Metabolic><Methylation><Mothers><NIH><NR3C1><NR3C1 gene><National Institutes of Health><North America><Nutracort><Oklahoma><Organizational Affiliation><Outcome><Pathway interactions><Perinatal><Peripartum><Phase><Pilot Projects><Prevention><Process><Proctocort><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Recording of previous events><Recovery><Research><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Risk><Salutogenesis><Science><Scientist><Substance abuse problem><System><Time><Tissue Growth><Training><Transmission><Trauma><United States National Institutes of Health><Universities><Veiled Cells><abuse of substances><adverse childhood events><adverse childhood experiences><behavior measurement><behavioral measure><behavioral measurement><biobehavior><biobehavioral><biologic><biological systems><build resilience><build resiliency><career><childhood adversity><community advisory board><community advisory committee><community advisory panel><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease-19 impact><cost><data depository><data repository><data set repository><dataset repository><design><designing><develop resilience><develop resiliency><developmental><early adversity><early childhood adversity><early life adversity><efficacy testing><emotion regulation><emotional regulation><enhance resilience><enhance resiliency><epidemiologic data><experience><experiment><experimental research><experimental study><experiments><fMRI><healing><health care><histories><improve resilience><improve resiliency><increase resilience><increase resiliency><infancy><infantile><innovate><innovation><innovative><intergenerational><juvenile><juvenile human><life course><mental illness><monocyte><multidisciplinary><neurobiological mechanism><neurofeedback><ontogeny><pathway><pediatric adversity><physical conditioning><physical health><pilot study><prevent><preventing><programs><promote resilience><promote resiliency><promoting health><protective factors><psychiatric illness><psychological disorder><recruit><resilience><resilience development><resilient><stress reactivity><substance abuse><transmission process><vaccine efficacy>