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Principal Investigator: Richelle J. Cooper
Organization: UNIVERSITY OF CALIFORNIA LOS ANGELES
Fiscal Year: 2024
Award: $354,349
Funding agency: National Institute of Neurological Disorders and Stroke
Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. The ongoing COVID- 19 pandemic has brought into stark relief the importance of emergency care research to rapidly evaluate treatments, and the disproportionate burden that underserved populations suffer. It is imperative that new approaches for timely diagnosis and equitable treatment of these conditions be efficiently developed. This renewal application is to continue and evolve the effective Southwest Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SW SIREN) Hub and Spoke system to conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and traumatic conditions. The SW SIREN consortium will leverage strong regionalized prehospital-medical center partnerships in major population centers in the Southwest (Los Angeles, Orange, and San Diego counties in California, Denver, Colorado, and Clark County, Nevada), with a continued focus on recruitment of underrepresented populations. The Hub-and-Spoke consortium is comprised of the Award Hub, 5 Core Spoke Medical Centers, 83 Additional Spoke Hospitals, and 5 County EMS systems. Within the consortium are a total of 10 tertiary-quaternary academic centers able to participate in complex intervention trials and an extensive range of frontline hospitals able to participate in simple pragmatic trials. Building upon our success in training and mentorship of fellows and mid-career clinical trialists, we will utilize six Clinical and Translational Science Awards and seven universities to identify and elevate the next generation of SIREN clinical trialists. Twelve Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the consortium and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults and children throughout the Southwest; 2) facilitate collaboration between emergency medicine physicians, disease specialists, and EMS systems throughout the Southwest in trial design and execution; 3) provide an educational environment that provides opportunities for designated SW SIREN junior faculty fellows to participate in clinical trial research under the supervision of experienced investigators and disseminates knowledge about emergency care to medical students, residents, fellows, and allied health professionals; and 4) ensure equitable participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.
Terms: <0-11 years old><21+ years old><Accident and Emergency department><Acute><Adult><Adult Human><Affect><African American group><African American individual><African American people><African American population><African Americans><Allied Health Personnel><Ambulances><American><Award><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><California><Cardiac><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Trials><Clinical Trials Network><Clinical and Translational Science Awards><Collaborations><Colorado><Complex><Country><County><Data Collection><Death><Dedications><Diagnosis><Disease><Disorder><ED Physician><ED care><ER care><ER physician><Emergencies><Emergency Care><Emergency Department><Emergency Department Physician><Emergency Department care><Emergency Medicine><Emergency Physician><Emergency Room care><Emergency Situation><Emergency care research><Emergency health care><Emergency healthcare><Emergency medical care><Emergency research><Emergency room><Emergency room physician><Enrollment><Ensure><Equity><Faculty><Fellowship Program><Goals><Hematology><Hispanic Americans><Hospital Departments><Hospital Personnel><Hospitals><Impairment><Individual><Infrastructure><Inpatients><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Intervention Trial><Interventional trial><Investigators><Investments><Knowledge><Leadership><Length of Life><Longevity><Los Angeles><MD students><Medical><Medical Students><Medical center><Medicine><Mentors><Mentorship><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multidisciplinary Collaboration><Multidisciplinary Research><Multisite clinical trial><NHLBI><NIH><NINDS><National Clinical Trials Network><National Heart, Lung, and Blood Institute><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nervous System><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Nevada><Nurses><Operative Procedures><Operative Surgical Procedures><Oranges><Paramedic><Paramedical Personnel><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Personal awareness><Physicians><Population><Pragmatic clinical trial><Productivity><Research><Research Personnel><Research Resources><Researchers><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Self Perception><Self image><Self view><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 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pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><decision-making capacity><disability><education atmosphere><educational atmosphere><educational environment><enroll><evidence base><experience><improved outcome><innovate><innovation><innovative><intellectual atmosphere><interest><interventional strategy><kids><learning atmosphere><learning environment><medical school students><member><new approaches><next generation><novel approaches><novel strategies><novel strategy><nurse><operation><operations><outreach><patient oriented outcomes><pediatric><performance site><pragmatic effectiveness trial><pragmatic trial><profession allied to medicine><recruit><respiratory><school atmosphere><school climate><self awareness><self knowledge><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><success><supportive medical personnel><surgery><training atmosphere><trial design><under representation of groups><under represented groups><under represented people><under represented populations><under served group><under served individual><under served people><under served population><underrepresentation of groups><underrepresented people><underserved group><underserved individual><underserved people><university atmosphere><youngster>