Document text
Principal Investigator: Mary Allison Barlow
Organization: JOHNS HOPKINS UNIVERSITY
Fiscal Year: 2024
Award: $2,826,539
Funding agency: National Institute on Drug Abuse
PROJECT SUMMARY
Drug and alcohol use related health problems and overdose deaths disproportionately impact quality and
longevity of life for many American Indian and Alaska Native (Indigenous) communities. The proposed
Community-Driven Indigenous Research, Cultural Strengths & Leadership to Advance Equity in Substance Use
Outcomes (CIRCLE) Center of Excellence (P50) aims to address drug use related health problems in
collaboration with diverse Indigenous communities. Through research, training, and outreach, we will respond to
calls from Indigenous Peoples for enhanced focus on recovery and prevention, sources of strength, culture and
family-based approaches to wellness, and policy solutions. The P50 projects and cores will operate with
emphasis on four cross-cutting domains, all centered on a bedrock of promoting Indigenous Health Equity: 1)
Indigenous & Allied Leadership; 2) Community/Tribally Based Participatory Research (C/TBPR); 3) Addressing
Heterogeneity via Precision Public Health; and 4) Centering Strengths, including Assessing Indigenous Cultural
Frameworks of Health. Reflecting these thematic approaches, the Center's overarching aims include conducting
impact-focused, C/TBPR to identify heterogeneity in substance use risk and protective factors and intervention
effects. We will also foster the development of Indigenous scholars to expand Indigenous autonomy, capacity
and innovation in research, practice, and policy surrounding alcohol and drug use. We further aim to expand and
deepen our engagement with educational facilities, researchers, Tribal and Urban Native communities, policy
makers, and the public to serve as a national resource for more rapid uptake and sharing of novel methods,
measures, and programs in service to Indigenous health equity. To achieve these goals, the Center will house
the following: 1) Administrative Core to oversee governance, administrative structures, scientific priorities, and
training activities; 2) Research Core to provide methodological expertise to support the research of the Center;
3) Pilot Project Core to support innovation in Indigenous drug use research, and 4) Three Research Projects that
will conduct multidisciplinary and synergistic science focused on drug use prevention, intervention, and policy.
The proposed work aligns with NIDA's Racial Equity Initiative action steps, including increased CBPR and equity-
driven partnerships to combat drug use inequities.
Terms: <Acceleration><Address><Alaska Indian><Alaska Native><Alaskan American><Alaskan Indian><Alaskan Native><Alaskan Native American><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Ally><American Indian><American Indians><Area><Attention><COBRE><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Center of Biomedical Research Excellence><Centers of Research Excellence><Cessation of life><Collaborations><Communities><Community Services><Data><Death><Development><Drug abuse><Drug usage><Drugs><Education><Educational aspects><Equity><EtOH abuse><EtOH drinking><EtOH use><Family><Fostering><Goals><Harm Minimization><Harm Reduction><Health><Heterogeneity><Indigenous><Indigenous Population><Inequity><Intervention><Intervention Strategies><Investigators><Leadership><Length of Life><Life><Longevity><Measures><Medication><Methodology><Methods><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Native People><Native-Born><Outcome><Pathway interactions><Pattern><Personal Satisfaction><Personalized medical approach><Persons><Pharmaceutical Preparations><Pilot Projects><Policies><Policy Maker><Population><Premature Mortality><Prevalence><Prevention><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Racial Equity><Recovery><Research><Research Grants><Research Personnel><Research Priority><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Science><Scientific Advances and Accomplishments><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Source><Structure><System><Time><Training><Training Activity><Translating><Tribal Participatory Research><Tribally Based Participatory Research><Tribally-driven participatory research><Tribes><Work><Workforce Development><abuse of drugs><abuses drugs><alcohol co-abuse><alcohol ingestion><alcohol intake><alcohol problem><alcohol product use><alcohol use><alcohol-related death><alcoholic beverage consumption><alcoholic drink intake><build resilience><build resiliency><burden of disease><burden of illness><combat><community based participatory research><community led research><community participatory research><community partnered participatory research><coping><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><develop resilience><develop resiliency><developmental><disease burden><drug abuse prevention><drug addiction prevention><drug use><drug use prevention><drug/agent><enhance resilience><enhance resiliency><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><evidence base><experience><hazardous alcohol use><health equity><improve resilience><improve resiliency><increase resilience><increase resiliency><indigenous community><individualized approach><innovate><innovation><innovative><intervention effect><interventional strategy><multidisciplinary><novel><outreach><overdose death><overdose fatalities><participatory action research><pathway><personalized approach><pilot study><precision approach><prevent drug abuse><prevent drug addiction><prevent drug use><prevent substance misuse><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><programs><promote resilience><promote resiliency><protective factors><resilience development><response><scientific accomplishments><scientific advances><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social health determinants><socio-economic><socio-economically><socioeconomically><socioeconomics><stressor><substance misuse><substance misuse prevention><substance use><substance using><tailored approach><training module><trend><tribally engaged research><tribally led research><tribally-driven research><uptake><well-being><wellbeing>