Document text
Principal Investigator: Daniel Olson
Organization: UNIVERSITY OF COLORADO DENVER
Fiscal Year: 2020
Award: $49,756
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY/ABSTRACT
This is an Administrative Supplement Application to carry out SARS-CoV-2 PCR testing in an existing NIAID-
funded study (1K23AI143967) evaluating the clinical and economic impacts of influenza in Guatemalan
agricultural workers. The Parent Study includes the enrollment of an existing cohort (n=2,706) of Guatemalan
agricultural workers with high rates of chronic medical conditions (CMCs) into a prospective active surveillance
system for cough and fever (severe acute respiratory illness [SARI]). Workers meeting the case definition are
tested for influenza A/B and RSV (Roche cobas® Liat RT-PCR Assay) and then clinical and economic
outcomes are assessed using follow up surveys and company reported absenteeism and productivity data.
This Administrative Supplement will allow us to maintain our cough/fever surveillance system, given an
increase in expected cases due to SARS-CoV-2, and to perform RT-PCR testing for SARS-CoV-2. We
hypothesize that, similar to influenza, COVID-19 will place a significant clinical and economic burden on
agricultural workers, especially the large proportion with CMCs, such as chronic kidney disease of unknown
origin (CKDu, aka “Mesoamerican nephropathy”), given existing data showing a significantly increased risk of
severe disease. Evaluating these outcomes in an existing prospective cohort will allow us to measure these
burdens on a population-level, which will provide critical data in understanding the true impact of disease. We
aim to implement our SARS-CoV-2 testing immediately, analyze and disseminate our results quickly, and
make samples from our specimen biobank (annual blood and urine, acute illness respiratory and blood)
available for additional research.
Terms: <2019 novel coronavirus><2019-nCoV><21+ years old><Absenteeism><Accounting><Active Follow-up><Acute><Acute Kidney Failure><Acute Kidney Insufficiency><Acute Renal Failure><Acute Renal Insufficiency><Acute respiratory infection><Administrative Supplement><Admission><Admission activity><Adult><Adult Human><Agricultural Workers><Agriculture><Area><Assay><Banana><Berlin><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Serum><Blood Urea><Blood Urea Nitrogen><COVID><COVID-19><COVID19><Chronic><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><CoV disease><Colorado><Communities><Consent><Cost of Illness><Coughing><Creatinine><Data><Disease><Disease Costs><Disorder><Economic Burden><Economics><Enrollment><Epidemiology><Facilities and Administrative Costs><Fever><Funding><Glycohemoglobin A><Glycosylated hemoglobin A><Grippe><Guatemala><Guatemalan><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health system><Hemoglobin A(1)><Hospital Admission><Hospitalization><Hospitals><Household><Human Development><Human Resources><Incidence><Indirect Costs><Infection><Influenza><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Injury to Kidney><Kidney Diseases><LMIC><Labor Forces><Linear Regressions><Link><Manpower><Measures><Medical><Mentors><Mesoamerican><NIAID><National Institute of Allergy and Infectious Disease><Natural History><Nephropathy><Orthomyxovirus Type A><Outcome><Parents><Population><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Production><Productivity><Prospective cohort><Protocol><Protocols documentation><Public Health><Pyrexia><RT-PCR><RTPCR><Renal Disease><Reporting><Research><Research Resources><Research Specimen><Resources><Respiratory Infections><Respiratory Tract Infections><Reverse Transcriptase Polymerase Chain Reaction><Risk><SARS Virus><SARS corona virus><SARS coronavirus><SARS-Associated Coronavirus><SARS-CoV><SARS-CoV-2><SARS-CoV2><SARS-Related Coronavirus><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Salaries><Sampling><Serum><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe acute respiratory syndrome coronavirus 2><Severities><Severity of illness><Sickness Cost><Site><Specimen><Survey Instrument><Surveys><System><Testing><Type A Influenza><Universities><Urine><Urine Urinary System><Vaccination><Viral><Virus><Visit><Wages><Wuhan coronavirus><active followup><adulthood><agricultural><agriculture worker><base><bio-markers><biobank><biologic marker><biomarker><biorepository><burden of disease><burden of illness><chronic kidney disease><cohort><corona virus disease><corona virus disease 2019><coronavirus disease><coronavirus disease 2019><cost><cost outcomes><cystatin C><disease burden><disease severity><economic impact><economic outcome><enroll><epidemiologic><epidemiological><febrile><febris><flu><flu infection><follow up><follow-up><followed up><followup><hemoglobin A1c><high risk group><high risk population><influenza infection><kidney disorder><kidney injury><low and middle-income countries><meetings><mortality><palm oil><palmolein><pathogen><personnel><population based><post gamma-globulins><post-gamma-protein><prospective><renal disorder><renal injury><respiratory><reverse transcriptase PCR><severe acute respiratory syndrome-CoV><socio-economic><socio-economically><socioeconomically><socioeconomics><years of life lost to disability><years of life lost to disease>