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Principal Investigator: Shadi Nahvi
Organization: ALBERT EINSTEIN COLLEGE OF MEDICINE
Fiscal Year: 2024
Award: $194,400
Funding agency: National Institute on Drug Abuse
ABSTRACT
Reductions in the health burden of tobacco and other substance use and of overdose mortality have not been
equitably distributed. A minority of persons with substance use disorder (SUD) access treatment. To improve
the equity in the delivery of evidence-based treatment of opioid-, tobacco- and other SUD, rigorous training is
needed to prepare the next generation of investigators in patient-oriented addictions research (POAR). I am a
general internist who has provided integrated primary care and opioid use disorder (OUD) treatment for over
16 years, co-direct fellowship programs to train general internists skills in SUD clinical care and research, and
lead a research program that aims to enhance tobacco treatment outcomes and delivery among persons with
co-occurring mental health and SUD. This Mid-Career Investigator Award will be used to support three
overarching career goals. First, this will formalize and expand my research mentoring activity to fellows and
early-career faculty focused on POAR. I will focus particularly on mentoring investigators from racial/ethnic
minority groups that are underrepresented in academic medicine and NIH-funded research. Second, I will
develop specific expertise in experimental and implementation science methods to enhance intervention
optimization and translation of clinical research findings to real-world application. The proposed research will
use a stakeholder-informed approach to develop and pilot test a flexible methadone treatment intervention.
This will both inform flexible, patient-centered, equitable care delivery in OUD treatment, and provide a
platform for research training for mentees in experimental and implementation science. Finally, I will develop
leadership skills in academic medicine to expand the research training infrastructure to promote equity and
diversity, and enhance research training in POAR. The proposed K24 application will leverage my strong
existing research program, an outstanding team of advisors, and robust institutional resources in research and
clinical care among persons with mental illness and SUD to support my career development and mentorship of
early-career investigators.
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and Maintenance><Recommendation><Regulation><Relapse><Reporting><Research><Research Personnel><Research Resources><Research Training><Researchers><Resources><SAMHSA><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV2 infection><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Safety><Schedule><Scientist><Self-Report><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Substance Abuse and Mental Health Services Administration><Substance Use Disorder><Survivors><Testing><Therapeutic><Tobacco><Tobacco Use Disorder><Toxicology><Training><Training and Infrastructure><Translating><Treatment Period><Treatment outcome><Underrepresented Groups><Underrepresented Populations><United 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treatment><mortality><new approaches><next generation><novel approaches><novel strategies><novel strategy><nurse><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid treatment program><opioid use><opioid use disorder><overdose death><overdose fatalities><overdose risk><pandemic><pandemic disease><patient centered><patient oriented><pilot test><prescribed medication><programs><psychiatric illness><psychological disorder><public health relevance><racial minority group><racial minority individual><racial minority people><racial minority population><randomisation><randomization><randomized control trial><randomized trial><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><real world application><reduce overdose><reduction in overdose><response><risk minimization><service availability><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><social stigma><stigma><substance use><substance use and disorder><substance use treatment><substance using><tobacco disorder><treatment access><treatment days><treatment duration><treatment provider><treatment risk><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people>