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Principal Investigator: MARY E PAUL
Organization: WESTAT, INC.
Fiscal Year: 2024
Award: $460,849
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
ABSTRACT Baylor College of Medicine
Harris County, which includes the City of Houston, is among the 48 counties in the United States (U.S.) in
which more than 50 percent of new HIV diagnoses occur. There is an urgent need for innovative and
collaborative new approaches to HIV treatment and prevention in adolescents and young adults (AYA) in
Houston. The long-term goal of this research is to move the U.S. and Houston area closer to ending the HIV
epidemic by addressing the issues involved in successful prevention and treatment of HIV in AYA. These goals
align with Adolescent Trials Network (ATN) research objectives and Houston Consortium partnerships will
allow research to be conducted in AYA in all five priority areas of the ATN: improving HIV testing, preventing
new infections, engaging youth in care, improving treatment and treatment effectiveness, and reducing
adverse HIV health outcomes due to COVID-19. We plan to accomplish the following specific aims as a site for
HIV care, research, and prevention in AYA. Aim 1 – Conduct the Trials of the ATN as identified by the ATN
Executive Committee (EC) and Scientific Leadership Committee (SLC): Baylor College of Medicine (BCM)
ATN site has a longstanding research unit with staff with years of experience working with AYA, both in a
clinical trials settings and in the community, who are living with HIV (LWH) or are at risk for HIV. Aim 2 –
Participate in the Development of Trials: BCM's ATN Project Lead and staff have years of experience in
development and conducting of clinical trials in AYA and so will work in collaboration with the ATN Operations
and Collaborations Center (OCC) to develop and conduct the trials performed in the ATN. In addition, the BCM
Youth Community Advisory Board, (YCAB), which has had members who have been active in the ATN Youth
Advisory Council (YAC) and National CAB, Youth Experts and Advocates for Health (ATN-YEAH), will evaluate
and provide input on developing studies and provide and enhance ideas for future studies. Aim 3 – Provide
Innovation Regarding Successful Recruitment and Enrollment of Participants: As an ATN Site Consortium, we
have the structure, experience, and outreach to approach this aim at multiple levels with outreach in hard-to-
reach AYA including racial and gender minority and homeless youth. Aim 4 – Provide Sites (Texas Children's
Hospital and Harris Health Northwest and Thomas Street Health Center) as well as outreach within the
Houston ATN Consortium, local laboratory capacity, and pharmacy support in order to conduct the ATN trials
in collaboration with the OCC. Aim 5 – Continued evaluation and adjustment of Houston collaborative
consortium leadership model for meaningful and continued community engagement as reflected in ATN
research study participation of AYA at risk for or LWH. We anticipate the expected outcomes of improvements
in each ATN priority area along the continuums of HIV infection and prevention. This project is high impact
because it will provide the necessary consortium in impacted communities of AYA in a high-priority region of
the U.S. to collaborate with the OCC to make sustainable progress in reaching the ATN goals.
Terms: <65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AIDS><AIDS Virus><AIDS prevention><AIDS test><AIDS/HIV><AIDS/HIV test><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adolescent Medicine Trials Network><Adolescent Trials Network><Adolescent and Young Adult><Advisory Committees><Advocate><Affect><African American group><African American individual><African American people><African American population><African Americans><Aged 65 and Over><Area><Black><Black race><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Caring><Children's Hospital><Cities><Clinical Trials><Collaborations><Communities><Conduct Clinical Trials><Coronavirus Infectious Disease 2019><County><Development><Discipline of Nursing><Drug Kinetics><Epidemic><Evaluation><Failure><Feedback><Future><Goals><HIV><HIV Infections><HIV Prevention><HIV diagnosis><HIV test><HIV-1 test><HIV-2 test><HIV/AIDS><HIV/AIDS prevention><HTLV-III Infections><HTLV-III-LAV Infections><Health><Health Inequity><Healthcare><Heterosexuals><Hispanic><Homeless Children><Homeless Youth><Human Immunodeficiency Viruses><Human Resources><Human T-Lymphotropic Virus Type III Infections><Human immunodeficiency virus test><Individual><Individuals from minority><Individuals of minority><Inequalities in Health><Inequities in Health><Infection><Intervention><Intervention Strategies><LAV-HTLV-III><Laboratories><Latine><Latino><Latinx><Lead><Leadership><Low income><Lymphadenopathy-Associated Virus><Manpower><Medicaid><Medical><Medicine><Minority Groups><Minority People><Minority Population><Minority individual><Modality><Modeling><Newly Diagnosed><Nursing><Nursing Field><Nursing Profession><On-Line Systems><Online Systems><Outcome><Pb element><Pediatric Hospitals><Pharmacies><Pharmacokinetics><Pharmacy facility><PrEP><Prevention><Reporting><Research><Risk><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Structure><Task Forces><Technology><Texas><Transmission><Treatment Effectiveness><Uninsured><United States><Virus-HIV><Work><Youth><Youth 10-21><above age 65><advisory team><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age group><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><case-based><college><collegiate><community advisory board><community advisory committee><community advisory panel><community based organizations><community engagement><community marginalization><community organizations><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><design><designing><developmental><engagement with communities><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><experience><gender minority adolescent><gender minority children><gender minority youth><health care><health inequalities><heavy metal Pb><heavy metal lead><high risk><human old age (65+)><improved><improved outcome><innovate><innovation><innovative><interventional strategy><male><marginalized community><meeting><meetings><member><motivational enhancement therapy><motivational interview><new approaches><novel approaches><novel strategies><novel strategy><old age><online computer><operation><operations><outreach><over 65 years><participant enrollment><patient enrollment><personnel><pre-exposure prophylaxis><prevent><preventing><prevention service><programs><racial minority><recruit><research study><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sexual minority group><sexual minority individual><sexual minority people><sexual minority population><testing services><transmission process><treatment services><uptake><web based><≥65 years>