Document text
Principal Investigator: Ronald G Collman
Organization: UNIVERSITY OF PENNSYLVANIA
Fiscal Year: 2024
Award: $2,940,869
Funding agency: National Institute of Allergy and Infectious Diseases
Overall
Modified Project Summary/Abstract Section
The Penn CFAR provides dynamic scientific leadership, organizational structure, resources, & infrastructure to advance AIDS research across the integrated campus of the University of Pennsylvania, Children’s Hospital of Philadelphia (CHOP) & the Wistar Institute. The CFAR catalyzes cutting-edge science & adds value to the Penn/CHOP/Wistar research enterprise through activities that could not be achieved by individual investigators or projects. The Center is comprised of >150 members from our 3 institutions, including 9 of the 12 Penn schools & 21 of 29 departments within the School of Medicine. CFAR success in the last 5 years is reflected in $217M in NIH AIDS funding over that time, key discoveries in AIDS priority areas including HIV reservoirs/cure, vaccine, immune function, prevention, engagement and implementation, comorbidities & other areas. The CFAR’s proactive outreach & engagement has drawn new investigators from disparate fields across campus to HIV/AIDS research; attracted 38 AIDS investigators newly appointed to faculty; established a vibrant partnership with the Philadelphia Department of Public Health; advanced research & capacity-building with the University of Botswana; broadened the scientific expertise within the trainee, faculty & research leadership communities; and begun a new initiative with regional HBCU Lincoln University.
A comprehensive strategic planning process over the past year has led us to refine CFAR priorities, Cores, SWGs & leadership to address emerging themes, leverage new expertise, cultivate new research leaders, & maintain a cutting-edge focus. We are evolving our highly successful Implementation Science SWG into a new IS Core, establishing an innovative SWG focused on “HIV Communication & Policy Research”, & refining the focus of our reservoirs SWG to “Single Cell Reservoirs & Immunology”. Looking ahead, the CFAR will support a Developmental Core & 7 refined & revised Shared Resource Cores (Clinical, Virus & Reservoirs Technology, Molecular & Translational Immunotechnology, Community Research & Engagement, Biostatistics & Data Science, Implementation Science, & International) providing essential support for its research mission.
To address the opportunities & challenges of the next 5 years, the CFAR has 4 highly inter-linked Specific Aims: (1) Provide scientific & administrative leadership & pilot funding to catalyze innovative, interdisciplinary research that will lead to new knowledge & solutions for the AIDS crisis; (2) Attract, train, mentor & support the next generation of AIDS researchers to ensure scientific progress, draw non-AIDS investigators into the field with cross-cutting expertise, launch next generation research leaders, and expand the range of expertise in AIDS research & leadership; (3) Support, monitor & continually evolve a set of efficient, dynamic & innovative Cores that both support AIDS investigators & lead the research agenda through development & dissemination of innovative technology that transforms scientific capacity, &; (4) Advance science & synergy through intra-campus, local, national & international partnerships, community engagement, & capacity building.
Terms: <AIDS><AIDS Virus><AIDS/HIV><Abbreviations><Acceleration><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Advisory Committees><Appointment><Area><Bechuanaland><Behavioral><Behavioral Research><Binding><Biomedical Research><Biometrics><Biometry><Biostatistics><Botswana><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><COVID-19><CV-19><Case Management><Cell Body><Cells><Cellular Immune Function><Children's Hospital><Clinical><Clinical Trials Unit><Collaborations><Communication Research><Communities><Coronavirus Infectious Disease 2019><Data Science><Development><Disparate><Educational Activities><Ensure><Epidemic><Evaluation><Faculty><Focus Groups><Fostering><Funding><Gender and Sexual Minorities><Genome><Goals><HBCUs><HIV><HIV vaccine><HIV/AIDS><HIV/AIDS Vaccines><Health><Health equity research><Historically Black Colleges><Historically Black Colleges and Universities><Historically Black Institution><Historically Black University><Human Immunodeficiency Viruses><Immune><Immunes><Immunology><Individual><Infrastructure><Injecting drug user><Injection Drug User><Institution><Interdisciplinary Research><Interdisciplinary Study><International><Intervention><Intervention Strategies><Investigators><Knowledge><LAV-HTLV-III><Lead><Leadership><Lymphadenopathy-Associated Virus><Lymphoid><Medical><Medicine><Mental Health><Mental Hygiene><Mentors><Messenger RNA><Mission><Modeling><Molecular><Molecular Interaction><Monitor><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><NIH Office of AIDS Research><National Institutes of Health><Organization Charts><PWID><Pb element><Pediatric Hospitals><Pennsylvania><Persons><Philadelphia><Pilot Projects><Policies><Policy Research><Position><Positioning Attribute><PrEP><Prevention><Primates><Primates Mammals><Process><Psychological Health><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Grants><Research Personnel><Research Priority><Research Project Grants><Research Projects><Research Resources><Research Support><Research in health equity><Researchers><Resource Sharing><Resources><SHIV><SIV><School Health Nursing><School Nursing><Schools><Science><Scientist><Sexual and Gender Minorities><Simian Immunodeficiency Viruses><Social Policies><Strategic Planning><T cells for CAR><Task Forces><Technology><The Wistar Institute><Time><Training><United States National Institutes of Health><Universities><Vaccines><Virus><Virus-HIV><YMSM><advisory team><antibody assay><antibody based test><antibody test><antiretroviral therapy><antiretroviral treatment><base><bases><biobehavior><biobehavioral><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical epidemiology><co-morbid><co-morbidity><collaboratory><community advisory board><community advisory committee><community advisory panel><community based organizations><community engagement><community organizations><community research><comorbidity><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><developmental><disparity in health><diversity and inclusion><diversity and inclusivity><diversity, equity, and inclusiveness><engagement with communities><equity, diversity, and inclusion><first in man><first-in-human><health disparity><health equity><health equity-focused research><heavy metal Pb><heavy metal lead><human immunodeficiency virus vaccine><immune function><implementation science><implementation strategy><innovate><innovation><innovative><innovative technologies><insight><international partnership><international research partnership><interventional strategy><mRNA><medical college><medical schools><member><neutralizing antibody><next generation><non-human primate><nonhuman primate><novel><organizational structure><outreach><people who inject drugs><people who inject illicit drugs><persons who inject drugs><pilot study><pre-exposure prophylaxis><programs><recruit><research on health equity><research related to health equity><research to attain health equity><school of medicine><simian HIV><simian human immunodeficiency virus><social><strategies for implementation><success><synergism><trafficking><trans*><transgender><work group><working group><young MSM><young men who have sex with men>