Document text
Principal Investigator: DAVID B. WEINER
Organization: WISTAR INSTITUTE
Fiscal Year: 2022
Award: $275,223
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary
The goal of this Program is to develop a next-generation, universal coronavirus synthetic nucleic acid vaccine
employing advancements in nucleic acid delivery of nanoparticles that will provide broad protection against
multiple seasonal and emerging CoV. There are seven CoV known to infect people, 4 human (HCoV-NL63, -
229E, -OC43, -HKU1) and 3 zoonotic that have crossed into humans in the past 20 years (SARS-CoV-1, SARS-
CoV-2, and MERS-CoV). Zoonotic CoV are introduced by cross-transmission events from animals and the most
concerning due to lack of immunity in people. Spread of future related viruses is of concern and new vaccine
strategies are urgently needed that will provide broad protection in people against multiple coronaviruses.
This program brings together the expertise of teams from The Wistar Institute (Drs. Weiner, Kulp, and Patel),
The University of Pennsylvania (Dr. Allman), and Indiana University (Dr. Pallesen). Together, the team has
significant experience in virology, immunology, protein engineering, and molecular and cellular biochemistry.
The Program is organized into 2 Research Projects, overseen by the Administrative Core (AC). Dr. Ami Patel
(The Wistar Institute) will serve as director for the AC.
The goal of the Administrative core (AC), led by Dr. Patel as part of a three-member leadership team consisting
of Dr. Kulp, Weiner and Patel, will provide overall governance and oversight to ensure the Program goals are
met. These goals will be achieved through active program management including administrative and financial
support, project monitoring and reporting, research compliance oversight, team communication, resource
management, conflict resolution, and intellectual property management. In these functions, the AC will be
responsible for overall program performance, personnel, sample distribution, and animal shipping coordination.
The AC will arrange regular team calls for open data discussion and timeline review and organize yearly review
meetings. The AC will arrange calls between the Program Direction, Project Leads and the NIH Program Office
and provide yearly reports on progress for program feedback as well as facilitate publication of findings and
scientific meeting attendance.
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