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Principal Investigator: Eric Jeffrey Topol
Organization: SCRIPPS RESEARCH INSTITUTE, THE
Fiscal Year: 2023
Award: $6,029,792
Funding agency: National Center for Advancing Translational Sciences
PROJECT SUMMARY / ABSTRACT
The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to
accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and
informatics/analytics fosters a multi-dimensional understanding of individualized human health. The Scripps hub
has previously included the Scripps Research Institute (SR) and Scripps Health (SH) as principal partners,
including Rady Children’s Institute of Genomic Medicine (RCIGM) for genomic medicine initiatives and California
Institute for Medical Research (Calibr) for drug repurposing / discovery. In the new CTSA cycle, our partners
have expanded to include San Diego State University (SDSU), enabling us to combine forces in computer
science, artificial intelligence, biosensors, and diversity inclusion and equity initatives.
SRTI’s expertise in genomics was highlighted during the pandemic. We became one of the country’s most
productive sequencing centers for SARS-CoV-2 by rapidly forming the “SEARCH” alliance to process samples
with the San Diego County Department of Health, UCSD, Sharp Health, California Department of Public Health,
Helix, and our partners RCIGM and SH.
Digital medicine has been one of SRTI’s core strengths, having pioneered the first remote, site-less digital clinical
trial and now expanding this methodology to address many other medical conditions such as health during
pregnancy and sleep disorders. Our Digital Trials Center launched the Digital Engagement & Tracking for Early
Control and Treatment Scripps (DETECT) study, and in a matter of weeks our team was able to accurately
predict the likelihood of Covid with SARS-CoV-2 using passively collected resting heart rate data from wristband
sensors and later to identify a physiologic signature that correlates with Long Covid (Post-Acute Sequelae or
SARS-CoV-2 Infection).
The Scripps hub will innovate clinical and translational science to improve human health across the lifespan and
diverse racial, ethnic, geographic and socioeconomic communities. The hub will provide a nurturing environment
for education, training, and career development with a focus on individualized health domains of genomics, digital
medicine, and biomedical informatics, to empower tomorrow’s diverse workforce.
Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AI system><Acceleration><Address><Aggregated Data><Area><Artificial Intelligence><Awareness><Biosensor><COVID-19 infection><COVID-19 virus><COVID-19 virus infection><COVID19 infection><COVID19 virus><California><Cardiac Chronotropism><Child><Child Youth><Children (0-21)><Clinical Research><Clinical Sciences><Clinical Study><Clinical Trials><CoV-2><CoV2><Collaborations><Communities><Computer Reasoning><Country><County><Data><Data Aggregation><Data Set><Dedications><Democracy><Diagnostic><Dimensions><Dissemination and Implementation><Diverse Workforce><Drug Screening><Ecologic Systems><Ecological Systems><Ecosystem><Education><Educational aspects><Elements><Ethics><Ethnic Origin><Ethnicity><Fostering><Foundations><Genomic medicine><Genomics><Geography><Goals><Health><Health Inequity><Health Informatics><Healthcare><Heart Rate><Human><Human Resources><Industry Collaboration><Industry Collaborators><Inequalities in Health><Inequities in Health><Informatics><Institute of Medicine><Institute of Medicine (U.S.)><Institution><Intervention><Intervention Strategies><Length of Life><Longevity><Machine Intelligence><Manpower><Medical><Medical Research><Methodology><Modeling><Modern Man><NAS/IOM><Outcome><PASC><Patients><Physiologic><Physiological><Population><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Preventive><Process><Productivity><Program Development><Public Health><Public Health Informatics><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Research><Research Grants><Research Institute><Research Project Grants><Research Projects><Research Resources><Resource Informatics><Resources><Rest><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 infection><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Science><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome related corona virus 2><Sight><Site><Sleep Disorders><Structure><Techniques><Time><Training><Translational Research><Translational Science><Universities><Vision><Voice><Workplace Diversity><Wuhan coronavirus><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><biological sensor><biomed informatics><biomedical informatics><career development><chronic COVID-19 sequelae><classroom environment><college atmosphere><collegial atmosphere><collegiate atmosphere><community engaged research><community engagement><computer science><computerized data processing><consumer informatics><coronavirus disease 2019 infection><coronavirus disease 2019 virus><coronavirus disease-19 virus><cost effective><customized therapy><customized treatment><data processing><data standardization><data standards><digital><digital medicine><digital models><digital platform><digital twin><diversity and inclusion><diversity and inclusivity><diversity, equity, and inclusiveness><drug repurposing><education atmosphere><educational atmosphere><educational environment><empowerment><equity, diversity, and inclusion><ethical><ethnic diversity><ethnically diverse><hCoV19><health care><health data><health equity><health inequalities><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><innovate><innovation><innovative><intellectual atmosphere><interoperability><interventional strategy><kids><learning atmosphere><learning environment><life span><lifespan><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><nCoV2><pandemic><pandemic disease><patient specific therapies><patient specific treatment><personnel><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><pregnancy disorder><programs><public health emergency><racial><racial background><racial diversity><racial origin><racially diverse><real time model><realtime model><repurposing agent><repurposing medication><response><school atmosphere><school climate><secondary analysis><sensor><sleep diseases><sleep dysfunction><sleep illness><sleep problem><socio-economic><socio-economically><socioeconomically><socioeconomics><tailored medical treatment><tailored therapy><tailored treatment><tool><training atmosphere><translation research><translation strategy><translational approach><translational investigation><translational strategy><unique treatment><university atmosphere><visual function><youngster>