Signaling by Chondroitin Sulfate Proteoglycans

NIH Pandemic-Era Grants

Pandemic Era Grants

2022

↗ Live URL (may be dead)

Document text

Principal Investigator: HERBERT M. GELLER
Organization: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Fiscal Year: 2022
Award: $834,034
Funding agency: National Heart Lung and Blood Institute

We demonstrated the the Lipid Phosphate Phosphatase-Related Proteins (PLPPRs) can modulate neuronal adhesion and the cytoskeleton through interactions with RhoGDI that modulated both RhoA and Rac1 GTPases.  Papers describing these results have been published. 

     PLPPRs, like many transmembrane receptors, are cleaved at an extracellular site near the membrane.  We have now demonstrated that this cleavage is through a furin-like protease.  The cleavage releases a fragment of the original receptor that associates with other transmembrane molecules.  In addition, we showed that this cleavage can be regulated.  Further experiments will determine the exact role of cleavage in modulating signal transduction.

Terms: <Adhesions><Affect><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><CNS Nervous System><CNS plasticity><CSGAG><Cell Communication and Signaling><Cell Signaling><Cellular Matrix><Central Nervous System><Chondroitin Sulfate Proteoglycan><Cicatrix><Core Protein><Cytoskeletal System><Cytoskeleton><Esteroproteases><GTP Phosphohydrolases><GTPases><Goals><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Injury><Intracellular Communication and Signaling><Investigation><Membrane><Modification><Natural regeneration><Nerve Cells><Nerve Regeneration><Nerve Unit><Neural Cell><Neuraxis><Neuro-regeneration><Neurocyte><Neuronal Plasticity><Neurons><Neuroregeneration><Paper><Peptidases><Peptide Hydrolases><Phosphatases><Phosphates><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Process><Property><Protease Gene><Proteases><Proteinases><Proteins><Proteolytic Enzymes><Publishing><Receptor Activation><Receptor Protein><Regeneration><RhoGDI><Role><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Site><astrocytic glia><biological signal transduction><central nervous system plasticity><chondroitin sulfate glycosaminoglycan><experiment><experimental research><experimental study><extracellular><guanosinetriphosphatase><injuries><inorganic phosphate><intracellular skeleton><lipid phosphate phosphatase><membrane structure><model of animal><model organism><nervous system regeneration><neural plasticity><neural regeneration><neuronal><neuroplastic><neuroplasticity><neuroregenerative><receptor><regenerate><regenerated nerve><rho GDI><rhoB p20 GDI><social role><sugar>