Document text
Principal Investigator: Colin S. Duckett
Organization: DUKE UNIVERSITY
Fiscal Year: 2024
Award: $953,343
Funding agency: National Institute of Allergy and Infectious Diseases
ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1)
To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest
operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted
facility functionality. To achieve this goal, we focus on several critical elements: the facility must be safely and
effectively operated through a functional and seamless management process, inculcating a culture of safety
that permeates throughout the entire organization; the systems that are vital to the operation of the facility must
be well-maintained, and where appropriate the scheduled replacement of key systems must be planned prior
to any likely systems failure (i.e. before the end of the lifespan of the system or equipment). Finally, and
consistent with the aforementioned culture of safety, it is essential that facility meets or exceeds all of the
regulatory standards that are required for all of our systems and equipment. The goals of this Facility
Management, Maintenance and Operations Core (Core 1) are to 1) provide expert management and oversight
of the BSL-3 space; 2) ensure proper preventative maintenance of all critical systems; and 3) ensure
continuous compliance with all applicable regulatory standards. This Core is foundational to the safe and
effective operation of the Duke RBL core, and as with all programs dedicated to managing and minimizing risk,
embodies a culture of iterative improvement and the highest of operating standards.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Alpha Virus><Animal Model><Animal Models and Related Studies><Applied Research><Applied Science><Area><Assay><Basic Research><Basic Science><Bioassay><Biological><Biological Assay><CMV><COVID-19 virus><COVID19 virus><Cellular Assay><Certification><CoV-2><CoV2><Communicable Diseases><Containment><Contractor><Coronaviridae><Coronavirus><Cricetinae><Cytomegalovirus><Dedications><Diagnostic><Disease Outbreaks><Domestic Rabbit><Drugs><Ebola><Elements><Emerging infection><Ensure><Equipment><Equipment and supply inventories><Event><Failure><Fee-for-Service Plans><Fees for Service><Ferrets><Flavivirus><Funding><Goals><Grippe><Group A Arboviruses><Group B Arbovirus><HCMV><HIV><Hamsters><Hamsters Mammals><Hemagglutination><Home><Human><Human Immunodeficiency Viruses><Immune response><Immunological response><Immunology><In Vitro><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Influenza><Influenza Virus><Inventory><Investigators><LAV-HTLV-III><Laboratories><Leadership><Lymphadenopathy-Associated Virus><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Maintenance><Malaria><Medication><Mice><Mice Mammals><Microbiology><Mission><Modern Man><Molecular><Murine><Mus><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Orthoflavivirus><Oryctolagus cuniculus><Outbreaks><Paludism><Pasteurella pestis><Pharmaceutical Preparations><Plasmodium Infections><Poxviridae><Poxviruses><Preparedness><Process><Proteins><Protocol><Protocols documentation><Publications><Rabbits><Rabbits Mammals><Readiness><Research><Research Design><Research Personnel><Research Support><Researchers><Resource Development><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Salivary Gland Viruses><Schedule><Scientific Publication><Secure><Serology><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Societies><Study Type><System><TB infection><Therapeutic><Time><Training><Training Support><Translational Research><Translational Science><Trust><Tuberculosis><United States National Institutes of Health><Universities><Vaccines><Vendor><Viral Burden><Viral Load><Viral Load result><Virus><Virus-HIV><Workforce Development><Wuhan coronavirus><Y pestis><Y. pestis><Yersinia pestis><ZIKA><animal imaging><biocontainment facility><biocontainment lab><biocontainment laboratory><biodefense><biologic><biosecurity><cell assay><corona virus><coronavirus disease 2019 virus><coronavirus disease-19 virus><cytomegalovirus group><design><designing><disseminated TB><disseminated tuberculosis><drug/agent><emergent infection><experience><future pandemic><global health><hCoV19><homes><host response><immune reconstitution><immune system response><immunoresponse><improved><in vivo><infection due to Mycobacterium tuberculosis><influenzavirus><instrumentation><laboratory facility><life span><lifespan><model of animal><mtb><multiplex assay><nCoV2><new vaccines><next generation vaccines><next pandemic><novel vaccines><operation><operations><pathogen><pox virus><programs><repair><repaired><risk minimization><sq. ft><square foot><study design><translation research><translational investigation><tuberculosis infection><tuberculous spondyloarthropathy><virology>