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Principal Investigator: JOSEPH M FOX
Organization: UNIVERSITY OF DELAWARE
Fiscal Year: 2020
Award: $686,141
Funding agency: National Institute of General Medical Sciences
Project Summary
Administrative Core
This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to
discover and apply new chemical biology tools for the study of biological pathways associated with disease, and
to develop computational approaches for understanding small molecule interactions with complex
macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new
chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to
survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of
infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl
eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that
yield specific immune responses in the lung to advance inhalable vaccine development, and computational
approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus
capsids.
The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of
the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of
summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC),
mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that
enables faculty to develop successful research programs and to attract funding for their work; (4) Development
of research, training & career development goals and capabilities. A plan for hiring and retaining successful
faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core
facilities and participation in COBRE sponsored events.
Terms: <AIDS Virus><ATP-Dependent Endoprotease Ti><Achievement><Achievement Attainment><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adjuvant><Advisory Committees><Area><Award><Biological><Biology><Biomedical Research><COBRE><Cancers><Capsid><Career Counseling><Career Guidance><Career Mobility><Cell Body><Cells><Center of Biomedical Research Excellence><Centers of Research Excellence><Chemicals><Clp Protease><Communicable Diseases><Core Facility><Development><Development and Research><Disease><Disorder><Educational workshop><Enzyme Gene><Enzymes><Event><Faculty><Foxes><Funding><Generalized Growth><Goals><Grant><Group Meetings><Growth><Growth and Development><Growth and Development function><HIV><Human><Human Biology><Human Immunodeficiency Viruses><Immune response><Immunological response><Immunology><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Infrastructure><Investigators><LAV-HTLV-III><Lead><Leadership><Legionella pneumonia><Legionella pneumophila Infections><Legionnaires' Disease><Legionnaires' pneumonia><Link><Lung><Lung Respiratory System><Lymphadenopathy-Associated Virus><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Macromolecular Complexes><Malignant Neoplasms><Malignant Tumor><Manuscripts><Maps><Mentors><Messenger RNA><Microbiology><Modeling><Modern Man><Modification><Molecular><Molecular Probes><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Occupational Guidance><Pathway interactions><Pb element><Phase><Pilot Projects><Postdoc><Postdoctoral Fellow><Preparation><Protease Ti><Publications><R & D><R&D><Regulation><Research><Research Associate><Research Personnel><Research Resources><Research Training><Researchers><Resources><Scientific Publication><Series><Structure><Students><TB infection><Task Forces><Therapeutic><Tissue Growth><Tuberculosis><Universities><Virus><Virus-HIV><Vocational Counseling><Vocational Guidance><Work><Workshop><Writing><advisory team><bacterial pathogen><career advancement><career counselor><career development><career transition><chemical synthesis><cohort><develop a vaccine><development of a vaccine><developmental><disseminated TB><disseminated tuberculosis><drug discovery><endopeptidase Clp><executive coaching><experience><faculty mentor><flexibility><flexible><formative assessment><formative evaluation><heavy metal Pb><heavy metal lead><host response><human disease><immunoresponse><infection due to Mycobacterium tuberculosis><mRNA><malignancy><meetings><member><nano particle><nano-sized particle><nanoparticle><nanosized particle><neoplasm/cancer><ontogeny><pathogenic bacteria><pathway><pilot study><post-doc><post-doctoral><programs><pulmonary><recruit><research and development><small molecule><success><support network><tool><tuberculosis infection><tuberculous spondyloarthropathy><vaccine development><vaccine formulation>