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Principal Investigator: MICHAEL J MORRIS
Organization: SLOAN-KETTERING INST CAN RESEARCH
Fiscal Year: 2024
Award: $1,177,039
Funding agency: National Cancer Institute
Project Summary/Abstract
The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research
Center aims to build the evidence base necessary to establish best practices for telehealth-enabled cancer
care. The overarching goal of the Center is to create a research hub that generates evidence, trains
investigators, and develops the research methods required to ignite the field of precision cancer care delivery.
Prior work demonstrates that oncology-focused telehealth can achieve favorable outcomes, but large-scale
trials have been limited to specific contexts like palliative care or survivorship. Adoption has been constrained
by restricted reimbursement. The MATCHES Center will help remediate this evidence gap by executing
prospective trials, conducting observational analyses, and training transdisciplinary researchers. Our research
theme focuses on the integration of multi-layered data from telehealth platforms, patient portals, mobile
tracking devices, and the electronic medical record to develop analytic methods that support personalized
care. We aim to develop a new paradigm in oncology—precision delivery—with the ultimate goal of matching
individual patients with the most beneficial combination of clinic-based or telehealth-supported home-setting
care at the appropriate time—all based on the totality of dynamically available data. We will accomplish this
goal by applying data science methods—including nimble trial designs and machine learning—that have had
limited application to telehealth to date. By establishing a research hub that nurtures investigators across
disciplines and provides training, tools, data, analytic methods, and venues for sharing knowledge and building
partnerships, we expect to accelerate progress in the science of care delivery. Our specific aims are 1) to
conduct impactful pragmatic trials of telehealth in oncology, 2) to analyze a large existing cache of
multidimensional observational data characterizing telehealth utilization and outcomes, 3) to train investigators
and equip them with the skills necessary to innovate within an evidence-based framework, and 4) to integrate
telehealth with other data streams and create and apply analytic methods to transform the field of precision
care delivery. An Administrative Core will coordinate activities and engage feedback from internal and external
stakeholders—including patients and the oncology workforce. Our Clinical Practice Network serves as an
innovation laboratory and comprises 7 outpatient clinics in NY and NJ with a shared informatics ecosystem
including telehealth capacity, digital monitoring, and a highly trafficked patient portal. This will enable us to
launch and execute a large pragmatic trial comparing in-person care to telehealth, with resources designed to
support home-based care using a cluster-randomized design. The Research & Methods Core will support the
Center by applying data science methods to extract and synthesize insights from telehealth and other data
streams to develop methods relevant to advancing precision cancer care delivery and the goals of equity,
efficacy, and efficiency to create an optimal experience for people being treated for cancer.
Terms: <Acceleration><Address><Adoption><Ambulatory Care Facilities><Biologic Models><Biological Models><Breast Cancer><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cancer Patient><Cancer Treatment><Cancers><Caring><Chronic><Clinic><Clinical Medical Sciences><Clinical Medicine><Communication><Computerized Medical Record><Custom><Data><Data Science><Devices><Diagnosis><Dimensions><Discipline><Diverse Workforce><Dose><Ecologic Systems><Ecological Systems><Ecosystem><Effectiveness><Electronic Health Record><Electronic Medical Record><Ensure><Equity><Explosion><Feedback><Future><Generalized Growth><Goals><Growth><Health Benefit><Health Services><Heart failure><Home><Individual><Inequity><Informatics><Institute of Medicine><Institute of Medicine (U.S.)><Intervention><Intervention Strategies><Intramuscular><Investigators><Knowledge><Laboratories><Link><Machine Learning><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Medicine><Metadata><Methods><Model System><Modeling><NAS/IOM><New Jersey><New York><Oncology><Oncology Cancer><Oral><Out-patients><Outcome><Outcome Measure><Outpatient Clinics><Outpatients><Palliative Care><Palliative Therapy><Palliative Treatment><Patients><Pattern><Persons><Physicians><Precision care><Prostate CA therapy><Prostate Cancer therapy><QOC><Quality of Care><Research><Research Design><Research Methodology><Research Methods><Research Personnel><Research Resources><Researchers><Resources><Risk><Rural><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Safety><Science><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Study Type><System><Techniques><Testing><Time><Tissue Growth><Training><Visit><Woman><Work><Workplace Diversity><access disparities><accessibility disparities><analytical method><anti-cancer therapy><asynchronous communication><asynchronous messaging><behavioral health><cancer care><cancer therapy><cancer-directed therapy><cardiac failure><care delivery><clinical practice><cluster randomized design><comfort care><complex data><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><customs><data streams><design><designing><digital data><digital monitoring><digital tool><disparities in access><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evidence base><experience><health care quality><health communication><health data><health equity><healthcare quality><homes><implementation science><individual patient><individualized cancer care><individualized care><individualized oncology><individualized patient care><inequality in access><inequity in access><inequity in accessibility><innovate><innovation><innovative><insight><interventional strategy><investigator training><m-Health><mHealth><machine based learning><machine learning based method><machine learning method><machine learning methodologies><malignancy><malignant breast tumor><measurable outcome><men><meta data><mobile health><multidisciplinary><neoplasm/cancer><novel><ontogeny><outcome measurement><pandemic><pandemic disease><patient portal><personalized care><personalized oncology><personalized patient care><pilot trial><pragmatic effectiveness trial><pragmatic trial><precision cancer care><precision cancer medicine><precision oncology><prospective><prostate cancer treatment><rational design><remediation><research and methods><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><study design><subcutaneous><subdermal><survivorship><telehealth><tool><trial comparing><trial design><virtual health visit><virtual visit>