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Principal Investigator: Ighovwerha Ofotokun
Organization: EMORY UNIVERSITY
Fiscal Year: 2023
Award: $525,581
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY/ABSTRACT
The Clinical Research Core (CRC) (Core D) provides services to support researchers conducting human
subjects research studies investigating the pathogenesis of HIV disease, treatment and prevention of HIV,
strategies to eliminate HIV from those who are infected, and the reduction of the long-term morbidity among
those with HIV infection. The Clinical Core will enable the conduct of scientifically rigorous HIV clinical and
translational research through the provision of state-of-the-art research infrastructure including shared
research space, laboratory services, and expert consultation in clinical research methods and study
implementation. To support investigators engaged in these activities the Core will expand the use of a
sophisticated clinical database, the “HIV Disease Registry” (>32,031 unique patients cared for at Emory-associated facilities, with 6,066,481 patient encounters representing over 123,972 person years of clinically
relevant data). The CRC will provide access to a diverse array of biological specimens and data from
populations traditionally under-represented in HIV research, including minority women, adolescents, pregnant
women, and minority men who have sex with men. The Core’s specimen repository provides access to
specimens and data from populations critical to high priority research questions, including elite controllers,
long-term non-progressors, people with acute HIV infection and/or acute HCV coinfection, and high-risk sero-negative men and women. The Core will foster career development of ESI and scientists new to HIV
translational research. The CRC proposes the following Specific Aims:
Aim 1. Facilitate the conduct of groundbreaking and community-responsive HIV clinical research via state-of-the-art research infrastructure, expansion of services to advance pediatric and adolescent research, and
collaboration with the CFAR Community Liaison Council for greater harmonization of multiple community
advisory boards to promote greater community engagement in all aspects of clinical research.
Aim 2. Expand the use of the HIV Disease Registry to enhance international data sharing, expand data
collection from Grady’s pediatric and adolescent population, and add data from Emory Healthcare.
Aim 3. Provide access to data-linked biological specimens from diverse populations, including
underrepresented groups in HIV research; renew the focus on children, adolescents, and young adults, while
continuing to strengthen the participation of women; and expand our biobank for emerging research such as
SARS CoV-2/HIV coinfection and vaccines.
Aim 4. Foster career development for the next generation of HIV researchers through Core services and
programs and through collaboration with the Developmental Core.
Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV vaccine><AIDS><AIDS Virus><AIDS prevention><Acceleration><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immuno-Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Acquired Immunologic Deficiency Syndrome><Acute><Address><Adherence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Area><Award><Basic Research><Basic Science><Biological><Biological Specimen Banks><Biological Substance Banks><COVID-19 vaccine><COVID-19 virus><COVID19 vaccine><COVID19 virus><Caliber><Career Mobility><Caring><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Research><Clinical Study><Clinical Trials><CoV-2><CoV2><Collaborations><Communities><Consultations><Country><Data><Data Collection><Development><Disease><Disorder><Dysfunction><Electronic Health Record><Epidemic><Equity><Faculty><Fostering><Functional disorder><Funding><Goals><HBV><HCV co-infection><HCV coinfection><HIV><HIV Infections><HIV Prevention><HIV/AIDS prevention><HTLV-III Infections><HTLV-III-LAV Infections><Health system><Healthcare><Hepatitis B Virus><Hepatitis C co-infection><Homologous Serum Hepatitis Virus><Human Immunodeficiency Viruses><Human Subject Research><Human T-Lymphotropic Virus Type III Infections><Individual><International><Investigators><LAV-HTLV-III><Laboratories><Link><Lymphadenopathy-Associated Virus><MSM><Medical center><Minority Female><Minority Male><Minority Men><Minority Women><Mission><Morbidity><Morbidity - disease rate><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Pathogenesis><Patient Care><Patient Care Delivery><Patients><Persons><Physiopathology><Play><Population><Population Heterogeneity><PrEP><Pregnant Women><Prevention><Publications><Registries><Research><Research Activity><Research Infrastructure><Research Methodology><Research Methods><Research Personnel><Research Priority><Research Resources><Research Specimen><Research Support><Researchers><Resources><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 vaccine><SARS-CoV2><SARS-CoV2 vaccine><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 vaccine><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Sampling><Science><Scientific Publication><Scientist><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 vaccine><Severe acute respiratory syndrome related corona virus 2><Specimen><Training><Training Support><Translational Research><Translational Science><Underrepresented Groups><Underrepresented Populations><United States National Institutes of Health><Universities><Vaccines><Veterans><Virus-HIV><Woman><Work><Wuhan coronavirus><biobank><biologic><biological specimen repository><biorepository><biosample repository><biospecimen bank><biospecimen repository><career advancement><career development><career transition><clinical database><clinical relevance><clinically relevant><co-infection><co-morbid><co-morbidity><cohort><coinfection><community engagement><comorbidity><consultation><corona virus disease 2019 vaccine><coronavirus disease 2019 vaccine><coronavirus disease 2019 virus><coronavirus disease-19 vaccine><coronavirus disease-19 virus><data diversity><data sharing><depository><developmental><disease registry><diverse data><diverse populations><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><expectant mother><expecting mother><hCoV19><health care><hepatitis C coinfection><hepatitis C virus co-infection><hepatitis C virus coinfection><heterogeneous population><high risk><improved><infection risk><innovate><innovation><innovative><juvenile><juvenile human><kids><member><men><men having sex with men><men who have sex with men><men who have sex with other men><microbicidal><microbicide><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><nCoV2><next generation><pathophysiology><pediatric><population diversity><pre-clinical research><pre-exposure prophylaxis><preclinical research><pregnant mothers><programs><repository><research and methods><research study><social role><specimen bank><specimen repository><tool><trans*><transgender><translation research><translational investigation><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><vaccine against 2019-nCov><vaccine against SARS-CoV-2><vaccine against SARS-CoV2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine for novel coronavirus><youngster>